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- 1From: Nature Genetics. (Vol. 42, Issue 7) Peer-ReviewedIL-10 exerts its anti-inflammatory effect through direct transcriptional control of cytokine expression as well as indirect modulation of the costimulatory properties of antigen-presenting cells. In the Proceedings of...
- 2From: Nature Genetics. (Vol. 42, Issue 7) Peer-ReviewedNatural killer (NK) cells are components of the innate immune system with important roles in tumor surveillance and antiviral defense. Pentao Liu and colleagues (Science, published online, doi:10.1126/science.1188063,...
- 3From: Nature Genetics. (Vol. 42, Issue 7) Peer-ReviewedWe conducted a genome-wide association study for testicular germ cell tumor, genotyping 298,782 SNPs in 979 affected individuals and 4,947 controls from the UK and replicating associations in a further 664 cases and...
- 4From: Nature Genetics. (Vol. 42, Issue 7) Peer-ReviewedSequence conservation of noncoding DNA across species can indicate functional conservation. However, a new study demonstrates notable differences between human and mouse stem cell regulatory networks, suggesting caution...
- 5From: Nature Genetics. (Vol. 42, Issue 7) Peer-ReviewedChromosomal rearrangements creating fusions of TMPRSS2 with ERG occur in half of all prostate cancers, but the function of the TMPRSS2-ERG fusion protein is unclear. Now, Arul Chinnaiyan, Jindan Yu and colleagues report...
- 6From: Nature Genetics. (Vol. 42, Issue 7) Peer-ReviewedPlatelet function mediates both beneficial and harmful effects on human health, but few genes are known to contribute to variability in this process. We tested association of 2.5 million SNPs with platelet aggregation...
- 7From: Nature Genetics. (Vol. 42, Issue 7) Peer-ReviewedAutism-spectrum disorder (ASD) is a heterogeneous group of conditions characterized by deficits in social interaction, impaired ability to communicate and stereotypic behavior patterns. Stephen Scherer and colleagues...
- 8From: Nature Genetics. (Vol. 42, Issue 7) Peer-ReviewedChronic or unresolved inflammation can lead to tissue damage or, during sepsis, to death. In Nature, Serhan and colleagues characterize a potent anti-inflammatory molecule, resolvin D2, which is naturally produced by...
- 9From: Nature Genetics. (Vol. 42, Issue 7) Peer-ReviewedThe critical day length triggering photoperiodic flowering is set as an acute, accurate threshold in many short-day plants, including rice (1,2). Here, we show that, unlike the Arabidopsis florigen gene FT (3), the rice...
- 10From: Nature Genetics. (Vol. 42, Issue 7) Peer-ReviewedViral dissemination requires the release of newly synthesized virions from hijacked cells. In Cell, Bieniasz and colleagues report how tetherin, an interferon-inducible protein, blocks the release of HIV and other...
- 11From: Nature Genetics. (Vol. 42, Issue 7) Peer-ReviewedBy combining genome-wide association data from 8,130 individuals with type 2 diabetes (T2D) and 38,987 controls of European descent and following up previously unidentified meta-analysis signals in a further 34,412...
- 12From: Nature Genetics. (Vol. 42, Issue 7) Peer-Reviewed
A genome-wide association study of nasopharyngeal carcinoma identifies three new susceptibility loci
To identify genetic susceptibility loci for nasopharyngeal carcinoma (NPC), a genome-wide association study was performed using 464,328 autosomal SNPs in 1,583 NPC affected individuals (cases) and 1,894 controls of... - 13From: Nature Genetics. (Vol. 42, Issue 7) Peer-ReviewedJoubert syndrome (JBTS), related disorders (JSRDs) and Meckel syndrome (MKS) are ciliopathies. We now report that MKS2 and CORS2 (JBTS2) loci are allelic and caused by mutations in TMEM216, which encodes an...
- 14From: Nature Genetics. (Vol. 42, Issue 7) Peer-ReviewedTo the Editor: Hughes et al. (1) suggested that a common deletion of the CFHR1 and CFHR3 genes (CFHR1-3[DELTA]) is associated with lower risk of age related macular degeneration (AMD) and that the effect is...
- 15From: Nature Genetics. (Vol. 42, Issue 7) Peer-ReviewedThe initial phase of the US National Institutes of Health Human Microbiome Project (HMP), which seeks to characterize the human microbiome, includes plans to produce reference genome sequences for 900 bacteria from the...
- 16From: Nature Genetics. (Vol. 42, Issue 7) Peer-ReviewedWe conducted a genome-wide association study of generalized vitiligo in the Chinese Han population by genotyping 1,117 cases and 1,429 controls. The 34 most promising SNPs were carried forward for replication in samples...
- 17From: Nature Genetics. (Vol. 42, Issue 7) Peer-ReviewedMacrophages engulf apoptotic cells to prevent immune responses to self antigens. In Nature Medicine, Chawla and colleagues show that PPAR-[delta], a sensor of fatty acids, is essential for efficient macrophage...
- 18From: Nature Genetics. (Vol. 42, Issue 7) Peer-ReviewedAlthough susceptibility loci identified through genome-wide association studies (GWAS) typically explain only a small proportion of the heritability, a classical quantitative genetic analysis now argues that considering...
- 19From: Nature Genetics. (Vol. 42, Issue 7) Peer-ReviewedCTL-mediated target cell killing requires polarization of the microtubule-organizing center (MTOC) and cytotoxic granules toward the target cell interface. In Immunity, groups led by Griffiths and Sykulev shed light on...
- 20From: Nature Genetics. (Vol. 42, Issue 7) Peer-ReviewedWe report a set of tools to estimate the number of susceptibility loci and the distribution of their effect sizes for a trait on the basis of discoveries from existing genome-wide association studies (GWASs). We propose...