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- 1From: Nature Genetics. (Vol. 42, Issue 6) Peer-ReviewedIdentification of alleles that improve crop production and lead to higher-yielding varieties are needed for food security. Here we show that the quantitative trait locus WFP (WEALTHY FARMER'S PANICLE) encodes OsSPL14...
- 2From: Nature Genetics. (Vol. 42, Issue 6) Peer-ReviewedGlioblastoma is a highly malignant type of brain tumor, and individuals with the disease have a median survival time of only 15 months. The Cancer Genome Atlas Research Network (Cancer Cell published online,...
- 3From: Nature Genetics. (Vol. 42, Issue 6) Peer-ReviewedIL-10 exerts its anti-inflammatory effect through direct transcriptional control of cytokine expression as well as indirect modulation of the costimulatory properties of antigen-presenting cells. In the Proceedings of...
- 4From: Nature Genetics. (Vol. 42, Issue 6) Peer-ReviewedBreast cancer is the most common cancer in women in developed countries. To identify common breast cancer susceptibility alleles, we conducted a genome-wide association study in which 582,886 SNPs were genotyped in...
- 5From: Nature Genetics. (Vol. 42, Issue 6) Peer-ReviewedTo the Editor: Mitochondrial DNA (mtDNA) mutations are a major cause of maternally inherited human disease. Mothers often harbor a mixture of mutated and wild-type mtDNA (heteroplasmy) and transmit varying...
- 6From: Nature Genetics. (Vol. 42, Issue 6) Peer-ReviewedTo identify new genetic risk factors for rheumatoid arthritis, we conducted a genome-wide association study meta-analysis of 5,539 autoantibody-positive individuals with rheumatoid arthritis (cases) and 20,169 controls...
- 7From: Nature Genetics. (Vol. 42, Issue 6) Peer-ReviewedLeslie Biesecker and colleagues have used targeted exon capture and sequencing to identify the cause of a rare X-linked developmental syndrome (Am. J. Hum. Genet. published online, doi:10.1016/j.ajhg.2010.04.007, 6 May...
- 8From: Nature Genetics. (Vol. 42, Issue 6) Peer-ReviewedMycobacterium tuberculosis is an obligate human pathogen capable of persisting in individual hosts for decades. We sequenced the genomes of 21 strains representative of the global diversity and six major lineages of the...
- 9From: Nature Genetics. (Vol. 42, Issue 6) Peer-ReviewedArticles in the Analysis format report primary research carried out on publications, datasets or research practices. We see Analyses as a way to generate new hypotheses, test data integrity and promote research...
- 10From: Nature Genetics. (Vol. 42, Issue 6) Peer-ReviewedCase-parent trios were used in a genome-wide association study of cleft lip with and without cleft palate. SNPs near two genes not previously associated with cleft lip with and without cleft palate (MAFB, most...
- 11From: Nature Genetics. (Vol. 42, Issue 6) Peer-ReviewedThe use of the circulatory system to deliver extracellular signals to distant targets is well known, especially for signals secreted in large quantities, such as hormones. In the Journal of Experimental Medicine, Kunder...
- 12From: Nature Genetics. (Vol. 42, Issue 6) Peer-Reviewed
Mutations in the SHANK2 synaptic scaffolding gene in autism spectrum disorder and mental retardation
Using microarrays, we identified de novo copy number variations in the SHANK2 synaptic scaffolding gene in two unrelated individuals with autism-spectrum disorder (ASD) and mental retardation. DNA sequencing of SHANK2... - 13From: Nature Genetics. (Vol. 42, Issue 6) Peer-ReviewedPaget's disease of bone (PDB) is a common disorder with a strong genetic component characterized by focal increases in bone turnover, which in some cases is caused by mutations in SQSTM1. To identify additional...
- 14From: Nature Genetics. (Vol. 42, Issue 6) Peer-ReviewedThe regulatory networks that control gene expression during development are in large part governed by sequence-specific binding of transcription factors to the genome. Yutaka Satou and colleagues report an analysis of...
- 15From: Nature Genetics. (Vol. 42, Issue 6) Peer-ReviewedTwo studies describe how regulatory variation at the rice gene OsSPL14 can lead to altered plant morphology and improve grain yield. These studies support the possibility of improving rice yield through changing plant...
- 16From: Nature Genetics. (Vol. 42, Issue 6) Peer-ReviewedRheumatoid arthritis is a common autoimmune disease with a complex genetic etiology. Here, through a genome-wide association study of rheumatoid arthritis, we identified a polymorphism in CCR6, the gene encoding...
- 17From: Nature Genetics. (Vol. 42, Issue 6) Peer-ReviewedSvante Paabo and colleagues report a draft sequence of the Neandertal genome of three females who lived in Croatia over 38,000 years ago (Science 328, 710-722, 2010). The analyzed DNA was isolated from bones recovered...
- 18From: Nature Genetics. (Vol. 42, Issue 6) Peer-ReviewedMacrophages engulf apoptotic cells to prevent immune responses to self antigens. In Nature Medicine, Chawla and colleagues show that PPAR-[sigma], a sensor of fatty acids, is essential for efficient macrophage...
- 19From: Nature Genetics. (Vol. 42, Issue 6) Peer-ReviewedA new study has identified rare de novo mutations in SHANK2 in individuals with autism and/or mental retardation. SHANK2 encodes a scaffolding protein present in excitatory synapses. This finding sheds some light on the...
- 20From: Nature Genetics. (Vol. 42, Issue 6) Peer-ReviewedUsing data from a genome-wide association study of 907 individuals with childhood acute lymphoblastic leukemia (cases) and 2,398 controls and with validation in samples totaling 2,386 cases and 2,419 controls, we have...