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- 1From: Nature Genetics. (Vol. 42, Issue 4) Peer-ReviewedChromatin plays a central role in eukaryotic gene regulation. We performed genome-wide mapping of epigenetically marked nucleosomes to determine their position both near transcription start sites and at distal...
- 2From: Nature Genetics. (Vol. 42, Issue 4) Peer-ReviewedH3.3 is a variant of histone H3 that is enriched in nucleosomes at transcriptionally active chromatin; the histone chaperone Hira is involved in H3.3 deposition. Now Deyou Zheng, C. David Allis and colleagues report...
- 3From: Nature Genetics. (Vol. 42, Issue 4) Peer-ReviewedAlthough genome-wide association studies (GWASs) have identified numerous loci associated with complex traits, imprecise modeling of the genetic relatedness within study samples may cause substantial inflation of test...
- 4From: Nature Genetics. (Vol. 42, Issue 4) Peer-ReviewedMacrophages engulf apoptotic cells to prevent immune responses to self antigens. In Nature Medicine, Chawla and colleagues show that PPAR-[delta], a sensor of fatty acids, is essential for efficient macrophage...
- 5From: Nature Genetics. (Vol. 42, Issue 4) Peer-ReviewedMalaria remains a major health burden in endemic countries, with no less than 243 million clinical cases worldwide in 2008 and an estimated 863,000 deaths (1). Malaria due to infection with the pathogen P. falciparum...
- 6From: Nature Genetics. (Vol. 42, Issue 4) Peer-ReviewedWe performed a second-generation genome-wide association study of 4,533 individuals with celiac disease (cases) and 10,750 control subjects. We genotyped 113 selected SNPs with [P.sup.GWAS] < [10.sup.-4] and 18 SNPs...
- 7From: Nature Genetics. (Vol. 42, Issue 4) Peer-ReviewedChronic or unresolved inflammation can lead to tissue damage or, during sepsis, to death. In Nature, Serhan and colleagues characterize a potent anti-inflammatory molecule, resolvin D2, which is naturally produced by...
- 8From: Nature Genetics. (Vol. 42, Issue 4) Peer-ReviewedIn the version of this article initially published, Stephen J. Tonna was inadvertently omitted from the author list, and the fourth author (Hiroyasu Tsukaguchi) was missing one of his affiliations. These errors have...
- 9From: Nature Genetics. (Vol. 42, Issue 4) Peer-ReviewedWe performed a genome-wide association analysis of 1,897,764 SNPs in 1,043 German ulcerative colitis (UC) cases and 1,703 controls. We discovered new associations at chromosome 7q22 (rs7809799) and at chromosome 22q13...
- 10From: Nature Genetics. (Vol. 42, Issue 4) Peer-ReviewedCTL-mediated target cell killing requires polarization of the microtubule-organizing center (MTOC) and cytotoxic granules toward the target cell interface. In Immunity, groups led by Griffiths and Sykulev shed light on...
- 11From: Nature Genetics. (Vol. 42, Issue 4) Peer-ReviewedImagine the Grand Prix, engines racing on the grid, pit teams poised, and the spectators' applause gradually thinning as their impatience grows. Someone, somewhere has forgotten to bring the starting flag. This odd mood...
- 12From: Nature Genetics. (Vol. 42, Issue 4) Peer-ReviewedTranscription factor (TF) interactions play a key role in the development of specific tissues. Now, Yoshihide Hayashizaki and colleagues of the FANTOM consortium map the combinatorial interactions between most...
- 13From: Nature Genetics. (Vol. 42, Issue 4) Peer-ReviewedRecent studies suggest that the composition of the gut microbiota influences host metabolism and contributes to obesity. In support of this hypothesis, Andrew Gewirtz and colleagues (Science, published online 4 March...
- 14From: Nature Genetics. (Vol. 42, Issue 4) Peer-ReviewedEosinophilic esophagitis (EoE) is an allergic disorder characterized by the accumulation of eosinophils in the esophagus. We report association of EoE with variants at chromosome 5q22 encompassing TSLP and WDR36...
- 15From: Nature Genetics. (Vol. 42, Issue 4) Peer-ReviewedCeliac disease is an autoimmune disorder of the small intestine caused by a reaction to storage proteins (called glutens) found in cereal grains. Affected individuals typically develop antibodies specific for gluten and...
- 16From: Nature Genetics. (Vol. 42, Issue 4) Peer-ReviewedTumor suppressor genes on the X chromosome may skew the gender distribution of specific types of cancer (1,2). T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive hematological malignancy with an increased...
- 17From: Nature Genetics. (Vol. 42, Issue 4) Peer-ReviewedMixed linear model (MLM) methods have proven useful in controlling for population structure and relatedness within genome-wide association studies. However, MLM-based methods can be computationally challenging for large...
- 18From: Nature Genetics. (Vol. 42, Issue 4) Peer-ReviewedAphids are plant-eating insects that are model systems for insect-plant interactions as well as major pests of agricultural crops. The International Aphid Genomics Consortium now reports the draft genome sequence of the...
- 19From: Nature Genetics. (Vol. 42, Issue 4) Peer-Reviewed3 if represented on only one array" should be removed. In" class="citation-snippet">In the version of this article initially published, the sentence under Table 1 on p. 1296 should stop after the words "and 430A arrays," and the words "or >3 if represented on only one array" should be removed. In...
- 20From: Nature Genetics. (Vol. 42, Issue 4) Peer-ReviewedAutosomal dominant spinocerebellar ataxias (SCAs) are genetically heterogeneous neurological disorders characterized by cerebellar dysfunction mostly due to Purkinje cell degeneration. Here we show that AFG3L2 mutations...