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- 1From: Nature Genetics. (Vol. 41, Issue 3) Peer-ReviewedWe identify the SLC22A3-LPAL2-LPA gene cluster as a strong susceptibility locus for coronary artery disease (CAD) through a genome-wide haplotype association (GWHA) study. This locus was not identified from previous...
- 2From: Nature Genetics. (Vol. 41, Issue 3) Peer-ReviewedNatural pigment variation is controlled by the agouti-melanocortin 1 receptor (Mc1r) pathway, which modulates the amount and type of pigment produced by melanocytes. In addition, the K locus, which encodes a R-defensin...
- 3From: Nature Genetics. (Vol. 41, Issue 3) Peer-ReviewedMyocardial infarction is a common disease and among the leading causes of death in the world. We previously reported association of variants in LGALS2, encoding galectin-2, with myocardial infarction susceptibility in a...
- 4From: Nature Genetics. (Vol. 41, Issue 3) Peer-ReviewedMutations at autosomal loci account for most cases of nonsyndromic mental retardation, but pinpointing of the underlying molecular lesions has been hampered by the limited availability of families suitable for linkage...
- 5From: Nature Genetics. (Vol. 41, Issue 3) Peer-ReviewedSleep disorders are common in humans, and sleep loss increases the risk of obesity and diabetes (1). Studies in Drosophila (2,3) have revealed molecular pathways (4-7) and neural tissues (8-10) regulating sleep; however,...
- 6From: Nature Genetics. (Vol. 41, Issue 3) Peer-ReviewedWe report the discovery of a mutation in the THAP1 gene in three Amish-Mennonite families with mixed-onset primary torsion dystonia (also known as DYT6 dystonia). Another mutation in a German family with primary torsion...
- 7From: Nature Genetics. (Vol. 41, Issue 3) Peer-ReviewedWe present a three-stage analysis of genome-wide SNP data in 1,222 German individuals with myocardial infarction and 1,298 controls, in silico replication in three additional genome-wide datasets of coronary artery...
- 8From: Nature Genetics. (Vol. 41, Issue 3) Peer-ReviewedHirschsprung's disease, or aganglionic megacolon, is caused by the failure of neural crest cells to populate the hindgut during development, resulting in the absence of enteric nerves from a segment of the intestinal...
- 9From: Nature Genetics. (Vol. 41, Issue 3) Peer-ReviewedDetermining the genetic architecture of complex traits is challenging because phenotypic variation arises from interactions between multiple, environmentally sensitive alleles. We quantified genome-wide transcript...
- 10From: Nature Genetics. (Vol. 41, Issue 3) Peer-ReviewedThe spontaneous dominant mouse mutant, Elbow knee synostosis (Eks), shows elbow and knee joint synosotsis, and premature fusion of cranial sutures. Here we identify a missense mutation in the Fgf9 gene that is...
- 11From: Nature Genetics. (Vol. 41, Issue 3) Peer-ReviewedTo Know Where He Lies: DNA Technology and the Search for Srebrenica's Missing By Sarah Wagner University of California Press, 2008 352 pp., hardcover, $55 ISBN 9780520255746 When Bosnian Serb forces overran the...
- 12From: Nature Genetics. (Vol. 41, Issue 3) Peer-ReviewedChromatin has a prominent role in the regulation of cellular processes that require DNA access, such as transcription and DNA replication and repair. Post-translational, covalent modifications (PTMs) of histones provide...
- 13From: Nature Genetics. (Vol. 41, Issue 3) Peer-ReviewedWe carried out a genome-wide association study among Chinese women to identify risk variants for breast cancer. After analyzing 607,728 SNPs in 1,505 cases and 1,522 controls, we selected 29 SNPs for a fast-track...
- 14From: Nature Genetics. (Vol. 41, Issue 3) Peer-ReviewedPierre Robin sequence (PRS) is an important subgroup of cleft palate. We report several lines of evidence for the existence of a 17824 locus underlying PRS, including linkage analysis results, a clustering of...
- 15From: Nature Genetics. (Vol. 41, Issue 3) Peer-ReviewedParkinson's disease (PD), dementia with Lewy bodies and multiple system atrophy, collectively referred to as synucleinopathies, are associated with a diverse group of genetic and environmental susceptibilities. The best...
- 16From: Nature Genetics. (Vol. 41, Issue 3) Peer-ReviewedMetagenomics studies sampling from heterogeneous environments have allowed researchers to address fundamental questions of microbial diversity and evolution but have also demonstrated the need for new methods to cope...
- 17From: Nature Genetics. (Vol. 41, Issue 3) Peer-ReviewedWe conducted a genome-wide association study testing single nucleotide polymorphisms (SNPs) and copy number variants (CNVs) for association with early-onset myocardial infarction in 2,967 cases and 3,075 controls. We...
- 18From: Nature Genetics. (Vol. 41, Issue 3) Peer-ReviewedCells respond to stimuli by changes in various processes, including signaling pathways and gene expression. Efforts to identify components of these responses increasingly depend on mRNA profiling and genetic library...
- 19From: Nature Genetics. (Vol. 41, Issue 3) Peer-ReviewedWe examined the association of common variants at the NPPA-NPPB locus with circulating concentrations of the natriuretic peptides, which have blood pressure-lowering properties. We genotyped SNPs at the NPPA-NPPB locus...
- 20From: Nature Genetics. (Vol. 41, Issue 3) Peer-ReviewedWe identified a marker in LINGO1 showing genome-wide significant association (P = 1.2 x [10.sup.-9], odds ratio = 1.55) with essential tremor. LINGO1 has potent, negative regulatory influences on neuronal survival and is...