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- 1From: Nature Genetics. (Vol. 41, Issue 12) Peer-ReviewedLeprosy has affected humans for at least 4,000 years, (1), with accounts of leprosy-like illnesses widespread though various cultures over many centuries. Once of global distribution, leprosy is now a curable infectious...
- 2From: Nature Genetics. (Vol. 41, Issue 12) Peer-ReviewedGene-environment associations are important in rheumatoid arthritis (RA) susceptibility, with an association existing between smoking, HLA- DR81 'shared epitope' alleles, PTPN22 and antibodies to cyclic citrullinated...
- 3From: Nature Genetics. (Vol. 41, Issue 12) Peer-ReviewedReductive evolution and massive pseudogene formation have shaped the 3.31-Mb genome of Mycobacterium leprae, an unculturable obligate pathogen that causes leprosy in humans. The complete genome sequence of M. leprae...
- 4From: Nature Genetics. (Vol. 41, Issue 12) Peer-ReviewedThe genome of the seventh plant to be sequenced, Cucumis sativus L., was assembled using the conventional longread Sanger sequencing and higher-throughput short-read technology. This genome is the entry point for...
- 5From: Nature Genetics. (Vol. 41, Issue 12) Peer-ReviewedIL-10 exerts its anti-inflammatory effect through direct transcriptional control of cytokine expression as well as indirect modulation of the costimulatory properties of antigen-presenting cells. In the Proceedings of...
- 6From: Nature Genetics. (Vol. 41, Issue 12) Peer-ReviewedInvestigations at targeted loci have revealed an association between open chromatin and the placement of double-strand breaks (DSBs) and crossovers during meiosis. Now, Jason Lieb and Gregory Copenhaver and colleagues...
- 7From: Nature Genetics. (Vol. 41, Issue 12) Peer-ReviewedUlcerative colitis is one of the principal forms of inflammatory bowel disease with complex manifestations. Although previous studies have indicated that there is a genetic contribution to the pathogenesis of ulcerative...
- 8From: Nature Genetics. (Vol. 41, Issue 12) Peer-ReviewedTo discover new rheumatoid arthritis (RA) risk loci, we systematically examined 370 SNPs from 179 independent loci with P< 0.001 in a published meta-analysis of RA genome-wide association studies (GWAS) of 3,393 cases...
- 9From: Nature Genetics. (Vol. 41, Issue 12) Peer-ReviewedBone marrow transplantation (BMT) is generally undertaken in the treatment of conditions such as leukemia that involve uncontrolled proliferation of cells of the bone marrow. BMT involves complete replacement of the...
- 10From: Nature Genetics. (Vol. 41, Issue 12) Peer-ReviewedWe performed a genome-wide association study (GWAS) in 1,713 individuals of European ancestry with Parkinson's disease (PD) and 3,978 controls. After replication in 3,361 cases and 4,573 controls, we observed two strong...
- 11From: Nature Genetics. (Vol. 41, Issue 12) Peer-ReviewedInduced pluripotent stem (iPS) cells are derived by epigenetic reprogramming, but their DNA methylation patterns have not yet been analyzed on a genome-wide scale. Here, we find substantial hypermethylation and...
- 12From: Nature Genetics. (Vol. 41, Issue 12) Peer-ReviewedThe use of the circulatory system to deliver extracellular signals to distant targets is well known, especially for signals secreted in large quantities, such as hormones. In the Journal of Experimental Medicine, Kunder...
- 13From: Nature Genetics. (Vol. 41, Issue 12) Peer-ReviewedTo identify susceptibility variants for Parkinson's disease (PD), we performed a genome-wide association study (GWAS) and two replication studies in a total of 2,011 cases and 18,381 controls from Japan. We identified a...
- 14From: Nature Genetics. (Vol. 41, Issue 12) Peer-ReviewedTransplantation and pregnancy, in which two diploid genomes reside in one body, can each lead to diseases in which immune cells from one individual target antigens encoded in the other's genome. One such disease,...
- 15From: Nature Genetics. (Vol. 41, Issue 12) Peer-ReviewedViral dissemination requires the release of newly synthesized virions from hijacked cells. In Cell, Bieniasz and colleagues report how tetherin, an interferon-inducible protein, blocks the release of HIV and other...
- 16From: Nature Genetics. (Vol. 41, Issue 12) Peer-ReviewedThe healthy human body plays host to approximately 100 trillion microbial cells. Rob Knight and colleagues surveyed microbiota in 27 body 'habitats' in several healthy adults (Science published online 5 November 2009;...
- 17From: Nature Genetics. (Vol. 41, Issue 12) Peer-ReviewedUlcerative colitis is a common form of inflammatory bowel disease with a complex etiology. As part of the Wellcome Trust Case Control Consortium 2, we performed a genome-wide association scan for ulcerative colitis in...
- 18From: Nature Genetics. (Vol. 41, Issue 12) Peer-ReviewedThe inflammatory bowel diseases (IBD) Crohn's disease and ulcerative colitis are common causes of morbidity in children and young adults in the western world. Here we report the results of a genome-wide association...
- 19From: Nature Genetics. (Vol. 41, Issue 12) Peer-ReviewedBringing us closer to the $1,000 genome, Complete Genomics reports the sequencing of three new individual human genomes using their nanoarray technology, at an average materials cost of $4,400 per genome (Science...
- 20From: Nature Genetics. (Vol. 41, Issue 12) Peer-ReviewedGlial cell line-derived neurotrophic factor signaling through the Ret receptor tyrosine kinase is crucial for ureteric bud branching morphogenesis during kidney development, yet few of the downstream genes are known....