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- 1From: Nature Genetics. (Vol. 41, Issue 1) Peer-ReviewedComparing levels of genetic variation between the X chromosome and autosomes can reveal the different demographic histories of males and females of a species. Taking this approach, two new studies report that the...
- 2From: Nature Genetics. (Vol. 41, Issue 1) Peer-ReviewedObesity results from the interaction of genetic and environmental factors. To search for sequence variants that affect variation in two common measures of obesity, weight and body mass index (BMI), both of which are...
- 3From: Nature Genetics. (Vol. 41, Issue 1) Peer-ReviewedLynch syndrome patients are susceptible to colorectal and endometrial cancers owing to inactivating germline mutations in mismatch repair genes, including MSH2 (ref. 1). Here we describe patients from Dutch and Chinese...
- 4From: Nature Genetics. (Vol. 41, Issue 1) Peer-ReviewedIn genome-wide association (GWA) data from 2,151 nondiabetic French subjects, we identified rsl387153, near MTNRIB (which encodes the melatonin receptor 2 (MT2)), as a modulator of fasting plasma glucose (FPG; P = 1.3 x...
- 5From: Nature Genetics. (Vol. 41, Issue 1) Peer-ReviewedGenome-wide association studies (GWAS) of longitudinal birth cohorts enable joint investigation of environmental and genetic influences on complex traits. We report GWAS results for nine quantitative metabolic traits...
- 6From: Nature Genetics. (Vol. 41, Issue 1) Peer-ReviewedThree new studies identify nearly 20 new loci for serum lipid levels using predominantly a prospective cohort study design which also permits extensive and unbiased characterization of environmental exposures. Given the...
- 7From: Nature Genetics. (Vol. 41, Issue 1) Peer-ReviewedTeams now dominate in the production of papers and particularly of high-impact papers, according to a study of nearly 20 million papers by Wuchty et al. (Science 316, 1036-1039; 2007). This fact will be immediately...
- 8From: Nature Genetics. (Vol. 41, Issue 1) Peer-ReviewedDNA transcription produces many short-lived noncoding transcripts with a potential regulatory function, but most have escaped detection by present technologies. By depleting a core component of the human RNA exosome...
- 9From: Nature Genetics. (Vol. 41, Issue 1) Peer-ReviewedHistone methylation and DNA methylation cooperatively regulate chromatin structure and gene activity. How these two systems coordinate with each other remains unclear. Here we study the biological function of...
- 10From: Nature Genetics. (Vol. 41, Issue 1) Peer-ReviewedTo identify previously unknown genetic loci associated with fasting glucose concentrations, we examined the leading association signals in ten genome-wide association scans involving a total of 36,610 individuals of...
- 11From: Nature Genetics. (Vol. 41, Issue 1) Peer-ReviewedCommon variants at only two loci, FTO and MC4R, have been reproducibly associated with body mass index (BMI) in humans. To identify additional loci, we conducted meta-analysis of 15 genome-wide association studies for...
- 12From: Nature Genetics. (Vol. 41, Issue 1) Peer-ReviewedHuman severe combined immunodeficiencies (SCID) are phenotypically and genotypically heterogeneous diseases (1). Reticular dysgenesis is the most severe form of inborn SCID. It is characterized by absence of granulocytes...
- 13From: Nature Genetics. (Vol. 41, Issue 1) Peer-ReviewedKarsten Suhre and colleagues report a genome-wide association study (GWAS) for metabolites present in human serum (PLoS Genet. 4, e1000282; 2008). The study included 284 men 55-79 years of age, selected from within the...
- 14From: Nature Genetics. (Vol. 41, Issue 1) Peer-ReviewedHeredity and Hope: The Case for Genetic Screening By Ruth Schwartz Cowan Harvard University Press, 2008 292 pp., hardcover, $27.95 ISBN 978-0674024243 The electric tapping of the keyboard has an almost audible...
- 15From: Nature Genetics. (Vol. 41, Issue 1) Peer-ReviewedAbnormalities in WNT signaling are implicated in a broad range of developmental anomalies and also in tumorigenesis (1). Here we demonstrate that germline mutations in WTX (FAM123B), a gene that encodes a repressor of...
- 16From: Nature Genetics. (Vol. 41, Issue 1) Peer-ReviewedComparisons of chromosome X and the autosomes can illuminate differences in the histories of males and females as well as shed light on the forces of natural selection. We compared the patterns of variation in these...
- 17From: Nature Genetics. (Vol. 41, Issue 1) Peer-ReviewedDNA methylation is an epigenetic mark directing stable, heritable gene silencing through development. a new study uncovers the importance of demethylation of the DNA methyltransferase-1 for maintenance of DNA...
- 18From: Nature Genetics. (Vol. 41, Issue 1) Peer-ReviewedThe identification of targets of virally encoded microRNAs is essential to understanding their role in the viral life cycle. A new study reports the successful use of a microarray-based approach to identify a key target...
- 19From: Nature Genetics. (Vol. 41, Issue 1) Peer-ReviewedGermline substitutions in the endothelial cell tyrosine kinase receptor TIE2 (encoded by TEK) cause a rare, inherited form of venous anomaly known as a mucocutaneous venous malformation (VMCM; refs. 1-3 and V.W., N.L.,...
- 20From: Nature Genetics. (Vol. 41, Issue 1) Peer-ReviewedIn an extended genome-wide association study of bone mineral density among 6,865 Icelanders and a follow-up in 8,510 subjects of European descent, we identified four new genomewide significant loci. These are near the...