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- 1From: Nature Genetics. (Vol. 40, Issue 9) Peer-ReviewedMyc proteins are powerful proto-oncoproteins and important promoters of growth and proliferation during normal development. They are thought to exercise their effects upon binding to their partner protein Max, and their...
- 2From: Nature Genetics. (Vol. 40, Issue 9) Peer-ReviewedUsing comparative sequencing approaches, we investigated the evolutionary history of the European-enriched 17q21.31 MAPT inversion polymorphism. We present a detailed, BAC-based sequence assembly of the inverted human H2...
- 3From: Nature Genetics. (Vol. 40, Issue 9) Peer-ReviewedSomatic cells can be reprogrammed to produce induced pluripotent stem (iPS) cells by introducing a set of transcription factors linked to pluripotency. Now George Daley and colleagues report the production of iPS cells...
- 4From: Nature Genetics. (Vol. 40, Issue 9) Peer-ReviewedUncertainty about the phase of strings of SNPs creates complications in genetic analysis, although methods have been developed for phasing population-based samples. However, these methods can only phase a small number of...
- 5From: Nature Genetics. (Vol. 40, Issue 9) Peer-ReviewedMice lacking MyD88, an adaptor protein that acts downstream of Toll-like receptors (TLRs) and interleukin-1 receptors (IL-1Rs), are susceptible to a broad range of bacterial, viral and fungal infections, highlighting an...
- 6From: Nature Genetics. (Vol. 40, Issue 9) Peer-ReviewedHedgehog signaling has a key role in hair follicle development, as well as in induction of the most common cancer in individuals of european descent, basal cell carcinoma (BCC). a new study shows that BCCs strongly...
- 7From: Nature Genetics. (Vol. 40, Issue 9) Peer-ReviewedThe developmental basis for the generation of divergent leaf forms is largely unknown. Here we investigate this problem by studying processes that distinguish development of two related species: Arabidopsis thaliana,...
- 8From: Nature Genetics. (Vol. 40, Issue 9) Peer-ReviewedWe carried out a multistage genome-wide association study of type 2 diabetes mellitus in Japanese individuals, with a total of 1,612 cases and 1,424 controls and 100,000 SNPs. The most significant association was...
- 9From: Nature Genetics. (Vol. 40, Issue 9) Peer-ReviewedBlood Matters: From Inherited Illness to Designer Babies, How the World and I Found Ourselves in the Future of the Gene By Masha Gessen Harcourt, 2008 336 pp., hardcover, $25 ISBN 978-0151013623 Early on...
- 10From: Nature Genetics. (Vol. 40, Issue 9) Peer-ReviewedWe carried out a genome-wide association study of schizophrenia (479 cases, 2,937 controls) and tested loci with P < [10.sup.-5] in up to 16,726 additional subjects. Of 12 loci followed up, 3 had strong independent...
- 11From: Nature Genetics. (Vol. 40, Issue 9) Peer-ReviewedFollowing recent success in genome-wide association studies, a critical focus of human genetics is to understand how genetic variation at implicated loci influences cellular and disease processes. Crohn's disease (CD) is...
- 12From: Nature Genetics. (Vol. 40, Issue 9) Peer-ReviewedDemographic inference based on SNP variation in public databases can be complicated by ascertainment biases associated with SNP discovery and population sampling. With the aim of establishing a genetic variation database...
- 13From: Nature Genetics. (Vol. 40, Issue 9) Peer-ReviewedTo identify susceptibility loci for bipolar disorder, we tested 1.8 million variants in 4,387 cases and 6,209 controls and identified a region of strong association (rsl0994336, P = 9.1 x [10.sup.-9]) in ANK3 (ankyrin...
- 14From: Nature Genetics. (Vol. 40, Issue 9) Peer-ReviewedDuane's retraction syndrome (DRS) is an eye movement disorder caused by aberrant innervation of extraocular muscles by cranial motor neurons. DRS occurs sporadically in about 0.1% of the general population, and can also...
- 15From: Nature Genetics. (Vol. 40, Issue 9) Peer-ReviewedTo the Editor: Recently, SNPs in KLK3 were found to be related to prostate cancer risk in a genome-wide association study (GWAS; 1,854 cases) (1) and two candidate gene investigations (596 and 209 cases, respectively)...
- 16From: Nature Genetics. (Vol. 40, Issue 9) Peer-ReviewedGeleophysic dysplasia is an autosomal recessive disorder characterized by short stature, brachydactyly, thick skin and cardiac valvular anomalies often responsible for an early death. Studying six geleophysic dysplasia...
- 17From: Nature Genetics. (Vol. 40, Issue 9) Peer-ReviewedPontocerebellar hypoplasias (PCH) represent a group of neurodegenerative autosomal recessive disorders with prenatal onset, atrophy or hypoplasia of the cerebellum, hypoplasia of the ventral pons, microcephaly, variable...
- 18From: Nature Genetics. (Vol. 40, Issue 9) Peer-ReviewedIn his 1898 treatise Marriages among the Deaf in America, Edward Allen Fay collected family history data from 4,471 nineteenth-century marriages of deaf individuals. These data were re-analyzed by Rose in 1975, who...
- 19From: Nature Genetics. (Vol. 40, Issue 9) Peer-ReviewedIn humans, most meiotic crossover events are clustered into short regions of the genome known as recombination hot spots. We have previously identified DNA motifs that are enriched in hot spots, particularly the 7-mer...
- 20From: Nature Genetics. (Vol. 40, Issue 9) Peer-ReviewedWikiGenes is the first wiki system to combine the collaborative and largely altruistic possibilities of wikis with explicit authorship. In view of the extraordinary success of Wikipedia there remains no doubt about the...