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- 1From: Nature Genetics. (Vol. 40, Issue 8) Peer-ReviewedIn horses, graying with age is an autosomal dominant trait associated with a high incidence of melanoma and vitiligo-like depigmentation. Here we show that the Gray phenotype is caused by a 4.6-kb duplication in intron 6...
- 2From: Nature Genetics. (Vol. 40, Issue 8) Peer-ReviewedWe explore the process of going from genome discovery to evaluation of medical impact and discuss emerging challenges faced by the scientific community. The need to confront these challenges is heightened in a climate...
- 3From: Nature Genetics. (Vol. 40, Issue 8) Peer-ReviewedWe have determined the high-resolution strand-specific transcriptome of the fission yeast S. pombe under multiple growth conditions using a novel RNA-DNA hybridization mapping (HybMap) technique. HybMap uses an antibody...
- 4From: Nature Genetics. (Vol. 40, Issue 8) Peer-ReviewedThe brachyolmias constitute a clinically and genetically heterogeneous group of skeletal dysplasias characterized by a short trunk, scoliosis and mild short stature. (1) Here, we identify a locus for an autosomal...
- 5From: Nature Genetics. (Vol. 40, Issue 8) Peer-ReviewedA new study of pigmentation in mice has revealed a surprising link between dark skin and defects in ribosomal proteins. The demonstration that this phenotype is mediated via cell-specific stabilization of p53 suggests...
- 6From: Nature Genetics. (Vol. 40, Issue 8) Peer-ReviewedSusceptibility to osteoarthritis, the most common human arthritis, is known to be influenced by genetic factors (1,2). Through a genome-wide association study using ~100,000 SNPs, we have identified a previously unknown...
- 7From: Nature Genetics. (Vol. 40, Issue 8) Peer-ReviewedTissue organization in Drosophila is regulated by the core planar cell polarity (PCP) proteins Frizzled, Dishevelled, Prickle, Van Gogh and Flamingo. Core PCP proteins are conserved in mammals and function in mammalian...
- 8From: Nature Genetics. (Vol. 40, Issue 8) Peer-ReviewedThe linked maternally expressed H19 and paternally expressed Igf2 genes use a CTCF-dependent DNA methylation-sensitive insulator to govern their allele-specific imprinting patterns. Contrary to expectations, anew study...
- 9From: Nature Genetics. (Vol. 40, Issue 8) Peer-ReviewedSpecification of germ cell fate is fundamental in development and heredity. Recent evidence indicates that in mice, specification of primordial germ cells (PGCs), the common source of both oocytes and spermatozoa, occurs...
- 10From: Nature Genetics. (Vol. 40, Issue 8) Peer-ReviewedComparisons between eutherians and marsupials suggest limited conservation of the molecular mechanisms that control genomic imprinting in mammals. We have studied the evolution of the imprinted IGF2-H19 locus in...
- 11From: Nature Genetics. (Vol. 40, Issue 8) Peer-ReviewedSeveral risk factors for Crohn's disease have been identified in recent genome-wide association studies. To advance gene discovery further, we combined data from three studies on Crohn's disease (a total of 3,230 cases...
- 12From: Nature Genetics. (Vol. 40, Issue 8) Peer-ReviewedThe Murder of Nikolai Vavilov: The Story of Stalin's Persecution of One of the Great Scientists of the Twentieth Century By Peter Pringle Simon & Schuster, 2008 370 pp., hardcover, $26 ISBN 978-0743264983...
- 13From: Nature Genetics. (Vol. 40, Issue 8) Peer-ReviewedMutations in genes encoding ribosomal proteins cause the Minute phenotype in Drosophila and mice, and Diamond-Blackfan syndrome in humans. Here we report two mouse dark skin (Dsk) loci caused by mutations in Rps19...
- 14From: Nature Genetics. (Vol. 40, Issue 8) Peer-ReviewedDevelopmentally regulated expression of the transcriptional repressor Prdm1 (Blimp1) in the early mammalian embryo controls global epigenetic changes required for specification of primordial germ cells. a new study...
- 15From: Nature Genetics. (Vol. 40, Issue 8) Peer-ReviewedThe domestication of crops involves a complex process of selection in plant evolution and is associated with changes in the DNA regulating agronomically important traits. Here we report the cloning of a newly identified...
- 16From: Nature Genetics. (Vol. 40, Issue 8) Peer-ReviewedReviewing last year's meeting, Enrico Petretto and colleagues (Nat. Genet. 39, 1299-1301; 2007) emphasized that recent successes in complex disease genetics rest upon rapid technological advances and the excellent...
- 17From: Nature Genetics. (Vol. 40, Issue 8) Peer-ReviewedIsolates of Salmonella enterica serovar Typhi (Typhi), a human-restricted bacterial pathogen that causes typhoid, show limited genetic variation. We generated whole-genome sequences for 19 Typhi isolates using 454...
- 18From: Nature Genetics. (Vol. 40, Issue 8) Peer-ReviewedTo identify renally expressed genes that influence risk for hypertension, we integrated expression quantitative trait locus (QTL) analysis of the kidney with genome-wide correlation analysis of renal expression profiles...
- 19From: Nature Genetics. (Vol. 40, Issue 8) Peer-ReviewedDespite successful mapping of several genes, including APP, underlying rare, autosomal dominant, early-onset forms of alzheimer's disease, there has been limited progress in identifying variants contributing to...
- 20From: Nature Genetics. (Vol. 40, Issue 8) Peer-ReviewedWe have previously described individuals presenting with transient neonatal diabetes and showing a variable pattern of DNA hypomethylation at imprinted loci throughout the genome. We now report mutations in ZFP57, which...