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- 1From: Nature Genetics. (Vol. 40, Issue 7) Peer-ReviewedFair color increases risk of cutaneous melanoma (CM) and basal cell carcinoma (BCC). Recent genome-wide association studies have identified variants affecting hair, eye and skin pigmentation in Europeans. Here, we assess...
- 2From: Nature Genetics. (Vol. 40, Issue 7) Peer-ReviewedMice that lack Notch signaling in the skin die at early postnatal stages, although the precise reasons have been unclear. Shadmehr Demehri and colleagues now show that loss of signaling downstream of Notch results in...
- 3From: Nature Genetics. (Vol. 40, Issue 7) Peer-ReviewedTo the Editor: Histone hyperacetylation is a commonly recognized molecular marker of histone deacetylase (HDAC) inhibition and is considered to be a permissive requirement for the radiosensitizing ability of HDAC...
- 4From: Nature Genetics. (Vol. 40, Issue 7) Peer-ReviewedAge-related macular degeneration (AMD) is a prevalent multifactorial disorder of the central retina (1-3). Genetic variants at two chromosomal loci, 1q31 and 10q26, confer major disease risks, together accounting for...
- 5From: Nature Genetics. (Vol. 40, Issue 7) Peer-ReviewedPigmentation traits are known risk factors for skin cancer. Now, three new studies provide insights into the genetic factors underlying these effects, and the results reveal a surprisingly complex picture of the...
- 6From: Nature Genetics. (Vol. 40, Issue 7) Peer-ReviewedIn blastocyst chimeras, embryonic stem (ES) cells contribute to embryonic tissues but not extraembryonic trophectoderm. Conditional activation of [HRas1.sup.Q61L] in ES cells in vitro induces the trophectoderm marker...
- 7From: Nature Genetics. (Vol. 40, Issue 7) Peer-ReviewedThe planar cell polarity (PCP) signaling system governs many aspects of polarized cell behavior. Here, we use an in vivo model of vertebrate mucociliary epithelial development to show that Dishevelled (Dvl) is essential...
- 8From: Nature Genetics. (Vol. 40, Issue 7) Peer-ReviewedGenetic studies of age-related macular degeneration (AMD), the most prevalent blinding condition among the elderly, have had both great success and deep controversy. A new study now begins to resolve contradictory views...
- 9From: Nature Genetics. (Vol. 40, Issue 7) Peer-ReviewedAlthough studies suggest that SNPs derived from HapMap provide promising coverage and power for association studies, the lack of alternative variation datasets limits independent analysis. Using near-complete variation...
- 10From: Nature Genetics. (Vol. 40, Issue 7) Peer-ReviewedNQO1 guards against oxidative stress and carcinogenesis and stabilizes p53. We find that a homozygous common missense variant (NQO1*2, rs1800566(T), NM 000903.2:c.558C>T) that disables NQO1 strongly predicts poor...
- 11From: Nature Genetics. (Vol. 40, Issue 7) Peer-ReviewedBmi1 plays an essential part in the self-renewal of hematopoietic and neural stem cells. To investigate its role in other adult stem cell populations, we generated a mouse expressing a tamoxifen-inducible Cre from the...
- 12From: Nature Genetics. (Vol. 40, Issue 7) Peer-ReviewedSchizophrenia is an etiologically heterogeneous psychiatric disease, which exists in familial and nonfamilial (sporadic) forms (1). Here, we examine the possibility that rare de novo copy number (CN) mutations with...
- 13From: Nature Genetics. (Vol. 40, Issue 7) Peer-ReviewedOne recently identified bacterial mechanism for viral resistance involves genetic spacers within clustered regularly interspaced short palindromic repeats (CRISPR). These CRISPR spacers show sequence identity to viral...
- 14From: Nature Genetics. (Vol. 40, Issue 7) Peer-ReviewedIn an effort to pinpoint potential genetic risk factors for schizophrenia, research groups worldwide have published over 1,000 genetic association studies with largely inconsistent results. To facilitate the...
- 15From: Nature Genetics. (Vol. 40, Issue 7) Peer-ReviewedAs the bombardment of the Allied advance descended on northern Italy in March of 1944, a young medical student was repeatedly forced to flee Padua. Yet Giuseppe Attardi persevered, receiving his MD from the University of...
- 16From: Nature Genetics. (Vol. 40, Issue 7) Peer-ReviewedWe conducted a genome-wide association pooling study for cutaneous melanoma and performed validation in samples totaling 2,019 cases and 2,105 controls. Using pooling, we identified a new melanoma risk locus on...
- 17From: Nature Genetics. (Vol. 40, Issue 7) Peer-ReviewedTo the Editor: Using fluorescence in situ hybridization on tissue microarrays (FISHTMA), Holst et al. (1) recently reported amplification of ESR1, the gene encoding estrogen receptor alpha, in 21% (358 of 1,739) of...
- 18From: Nature Genetics. (Vol. 40, Issue 7) Peer-ReviewedWnt ligands are secreted glycoproteins with critical roles in organogenesis, cancer initiation and progression, and maintenance of stem cell pluripotency. a new study strengthens considerably our understanding of the...
- 19From: Nature Genetics. (Vol. 40, Issue 7) Peer-ReviewedWe present results from a genome-wide association study for variants associated with human pigmentation characteristics among 5,130 Icelanders, with follow-up analyses in 2,116 Icelanders and 1,214 Dutch individuals. Two...
- 20From: Nature Genetics. (Vol. 40, Issue 7) Peer-ReviewedA key goal of biology is to construct networks that predict complex system behavior. We combine multiple types of molecular data, including genotypic, expression, transcription factor binding site (TFBS), and...