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- 1From: Nature Genetics. (Vol. 40, Issue 5) Peer-ReviewedRecently, TDP-43 was identified as a key component of ubiquitinated aggregates in amyotrophic lateral sclerosis (ALS), an adult-onset neurological disorder that leads to the degeneration of motor neurons. Here we report...
- 2From: Nature Genetics. (Vol. 40, Issue 5) Peer-ReviewedKras is commonly mutated in colon cancers, but mutations in Nras are rare. We have used genetically engineered mice to determine whether and how these related oncogenes regulate homeostasis and tumorigenesis in the...
- 3From: Nature Genetics. (Vol. 40, Issue 5) Peer-ReviewedTo the editor: Although the laboratory rat is increasingly being used as a mammalian model in biomedical research, no technology exists thus far for the production of in vivo genetically engineered mutations equivalent...
- 4From: Nature Genetics. (Vol. 40, Issue 5) Peer-ReviewedCommon variants in CYP2C9 and VKORCI are associated with dose requirement for warfarin, an anticoagulant drug. The optimal dose of warfarin, defined by a standardized measure of clotting tendency, the international...
- 5From: Nature Genetics. (Vol. 40, Issue 5) Peer-ReviewedAdult human height is one of the classical complex human traits (1). We searched for sequence variants that affect height by scanning the genomes of 25,174 Icelanders, 2,876 Dutch, 1,770 European Americans and 1,148...
- 6From: Nature Genetics. (Vol. 40, Issue 5) Peer-ReviewedX-chromosome inactivation is the mammalian dosage compensation mechanism by which transcription of X-linked genes is equalized between females and males. In an N-ethyl-N-nitrosourea (ENU) mutagenesis screen on mice for...
- 7From: Nature Genetics. (Vol. 40, Issue 5) Peer-ReviewedCancer cells possess traits reminiscent of those ascribed to normal stem cells. It is unclear, however, whether these phenotypic similarities reflect the activity of common molecular pathways. Here, we analyze the...
- 8From: Nature Genetics. (Vol. 40, Issue 5) Peer-ReviewedElizabeth Blackburn and the Story of Telomeres By Catherine Brady MIT Press, 2007 392 pp., hardcover, $29.95 ISBN 978-0262026222 The study of telomeres, the specialized structures at the ends of chromosomes,...
- 9From: Nature Genetics. (Vol. 40, Issue 5) Peer-ReviewedB cells, αβ T cells and γδ T cells are conserved lymphocyte subtypes encoding their antigen receptors from somatically rearranged genes. αβ T cells undergo positive selection in the thymus by engagement of their T cell...
- 10From: Nature Genetics. (Vol. 40, Issue 5) Peer-ReviewedIron deficiency is usually attributed to chronic blood loss or inadequate dietary intake. Here, we show that iron deficiency anemia refractory to oral iron therapy can be caused by germline mutations in TMPRSS6, which...
- 11From: Nature Genetics. (Vol. 40, Issue 5) Peer-ReviewedThe laboratory rat was the first mammalian species domesticated for scientific research and has been a well-studied animal model across the biomedical sciences. Inbred strains of rats, first established by Helen Dean...
- 12From: Nature Genetics. (Vol. 40, Issue 5) Peer-ReviewedTo identify colorectal cancer (CRC) susceptibility alleles, we conducted a genome-wide association study. In phase 1, we genotyped 550,163 tagSNPs in 940 familial colorectal tumor cases (627 CRC, 313 high-risk adenoma)...
- 13From: Nature Genetics. (Vol. 40, Issue 5) Peer-ReviewedThe effects of alleles in many genes are believed to contribute to common complex diseases such as hypertension. Whether risk alleles comprise a small number of common variants or many rare independent mutations at trait...
- 14From: Nature Genetics. (Vol. 40, Issue 5) Peer-ReviewedGenome-wide association studies have identified many variants affecting susceptibility to disease. Now, three studies use this approach to study adult height variation in a combined sample size of -63,000 individuals and...
- 15From: Nature Genetics. (Vol. 40, Issue 5) Peer-ReviewedThe progression of carcinomas to high-grade malignancies is accompanied by profound histological changes in the tumor-associated stroma. Although previous studies have suggested that mesenchymal cells of the stroma...
- 16From: Nature Genetics. (Vol. 40, Issue 5) Peer-ReviewedIn a genome-wide association study to identify loci associated with colorectal cancer (CRC) risk, we genotyped 555,510 SNPs in 1,012 early-onset Scottish CRC cases and 1,012 controls (phase 1). In phase 2, we genotyped...
- 17From: Nature Genetics. (Vol. 40, Issue 5) Peer-ReviewedGenetically identical honeybee larvae develop into either worker bees or queen bees depending on exposure to royal jelly. Now Ryszard Maleszka and colleagues report that disruption of epigenetic programming can alter the...
- 18From: Nature Genetics. (Vol. 40, Issue 5) Peer-ReviewedCrescentic glomerulonephritis is an important cause of human kidney failure for which the underlying molecular basis is largely unknown. In previous studies, we mapped several susceptibility loci, Crgn1-Crgn7, for...
- 19From: Nature Genetics. (Vol. 40, Issue 5) Peer-ReviewedJoshua Lederberg died on February 2, 2008. Although the immediate cause was pneumonia, he had been troubled by a bad back for some time. With his originality and breadth and depth of knowledge, he was one of the greatest...
- 20From: Nature Genetics. (Vol. 40, Issue 5) Peer-ReviewedHeight is a classic polygenic trait, reflecting the combined influence of multiple as-yet-undiscovered genetic factors. We carried out a meta-analysis of genome-wide association study data of height from 15,821...