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- 1From: Nature Genetics. (Vol. 40, Issue 2) Peer-ReviewedHIF prolyl hydroxylases (PHD1-3) are oxygen sensors that regulate the stability of the hypoxia-inducible factors (HIFs) in an oxygen-dependent manner. Here, we show that loss of Phd1 lowers oxygen consumption in skeletal...
- 2From: Nature Genetics. (Vol. 40, Issue 2) Peer-ReviewedMetabolite-sensing riboswitches are elements controlling gene expression typically found in the noncoding portions of mRNAs. Most known riboswitches are found in the 5' UTRs of bacterial mRNAs or in introns of 5' UTRs or...
- 3From: Nature Genetics. (Vol. 40, Issue 2) Peer-ReviewedCompanies now provide individuals with their own genotypes and associated risks extrapolated from association studies. The best outcomes would be to convert patients into active investigators and navigators of their own...
- 4From: Nature Genetics. (Vol. 40, Issue 2) Peer-ReviewedThe discovery of new risk variants for systemic lupus erythematosis (SLE), particularly around lymphocyte signaling pathways and integrins involved in clearing complement, provides fresh insights into this common human...
- 5From: Nature Genetics. (Vol. 40, Issue 2) Peer-ReviewedWe have performed a genome-wide analysis of common genetic variation controlling differential expression of transcript isoforms in the CEU HapMap population using a comprehensive exon tiling microarray covering 17,897...
- 6From: Nature Genetics. (Vol. 40, Issue 2) Peer-ReviewedInterbreeding depends on genetic compatibility, with selection expected to weed out any incompatibilities from such populations. Hannah Seidel and colleagues report an unusual example of widespread incompatibility in...
- 7From: Nature Genetics. (Vol. 40, Issue 2) Peer-ReviewedSystemic lupus erythematosus (SLE) is a prototypical autoimmune disease characterized by production of autoantibodies and complex genetic inheritance (1-3). In a genome-wide scan using 85,042 SNPs, we identified an...
- 8From: Nature Genetics. (Vol. 40, Issue 2) Peer-ReviewedSystemic lupus erythematosus (SLE) is a common systemic autoimmune disease with complex etiology but strong clustering in families ([λ.sub.S] = B30). We performed a genome-wide association scan using 317,501 SNPs in 720...
- 9From: Nature Genetics. (Vol. 40, Issue 2) Peer-ReviewedWe tested over 267,000 SNPs in 1,005 Northern Europeans and 248,000 in 1,006 Indian Asians for association with triglycerides and HDL cholesterol, with replication in 10,536 subjects. We found association of a...
- 10From: Nature Genetics. (Vol. 40, Issue 2) Peer-ReviewedAlthough much of current HIV treatment efforts involve targeting viral enzymes, typically in combination, the alternative approach of targeting human host cell proteins required for the viral lifecycle has also been...
- 11From: Nature Genetics. (Vol. 40, Issue 2) Peer-ReviewedTo the Editor: A recent Commentary (1) makes interesting points about Islamic ethics. In response to the author's explanation of the Iranian experience, we would like to add some comments. First of all, one of the...
- 12From: Nature Genetics. (Vol. 40, Issue 2) Peer-ReviewedThe most severe forms of motoneuron disease manifest in utero are characterized by marked atrophy of spinal cord motoneurons and fetal immobility. Here, we report that the defective gene underlying lethal motoneuron...
- 13From: Nature Genetics. (Vol. 40, Issue 2) Peer-ReviewedWe identified and replicated an association between ITGAM (CD11b) at 16p11.2 and risk of systemic lupus erythematosus (SLE) in 3,818 individuals of European descent. The strongest association was at a nonsynonymous SNP,...
- 14From: Nature Genetics. (Vol. 40, Issue 2) Peer-ReviewedIdentifying genetic variants that influence human height will advance our understanding of skeletal growth and development. Several rare genetic variants have been convincingly and reproducibly associated with height in...
- 15From: Nature Genetics. (Vol. 40, Issue 2) Peer-ReviewedEutherian placenta, an organ that emerged in the course of mammalian evolution, provides essential architecture, the so-called feto-maternal interface, for fetal development by exchanging nutrition, gas and waste between...
- 16From: Nature Genetics. (Vol. 40, Issue 2) Peer-ReviewedWe have featured many fascinating mutants in 'Mutant of the Month,' so this month we are taking an appreciative look back at them. Mutants are chosen by different editors and for different reasons, so it is interesting...
- 17From: Nature Genetics. (Vol. 40, Issue 2) Peer-ReviewedTo identify genetic variants influencing plasma lipid concentrations, we first used genotype imputation and meta-analysis to combine three genome-wide scans totaling 8,816 individuals and comprising 6,068 individuals...
- 18From: Nature Genetics. (Vol. 40, Issue 2) Peer-ReviewedMany organisms have an amazing capacity to adapt to conditions of low oxygen, but the cellular mechanisms of this are poorly understood. A new study in mice has unveiled a molecular trigger that initiates a cascade of...
- 19From: Nature Genetics. (Vol. 40, Issue 2) Peer-ReviewedErratum: PU.1 is a major downstream target of AML1 (RUNX1) in adult mouse hematopoiesis Gang Huang, Pu Zhang, Hideyo Hirai, Shannon Elf, Xiaomei Yan, Zhao Chen, Steffen Koschmieder, Yutaka Okuno, Tajhal Dayaram, Joseph...
- 20From: Nature Genetics. (Vol. 40, Issue 2) Peer-ReviewedTo the Editor: Recent successes in large-scale genetic association studies call for renewed attention to integrating research results, not only among studies, but across disciplines (1). At the molecular level, genetic...