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- Search Terms:ISSN: 15537390AndISSN: 15537404AndVolume Number: 4AndIssue Number: 9AndStart Page: e1000190AndDate: 2008 Revise Search
- 1From: PLoS Genetics. (Vol. 4, Issue 9) Peer-ReviewedComparisons of levels of variability on the autosomes and X chromosome can be used to test hypotheses about factors influencing patterns of genomic variation. While a tremendous amount of nucleotide sequence data from...
- 2From: PLoS Genetics. (Vol. 4, Issue 9) Peer-ReviewedQuantitative trait transmission/disequilibrium tests (quantitative TDTs) are commonly used in family-based genetic association studies of quantitative traits. Despite the availability of various quantitative TDTs, some...
- 3From: PLoS Genetics. (Vol. 4, Issue 9) Peer-ReviewedDuring meiotic prophase, chromosomes display rapid movement, and their telomeres attach to the nuclear envelope and cluster to form a "chromosomal bouquet." Little is known about the roles of the chromosome movement and...
- 4From: PLoS Genetics. (Vol. 4, Issue 9) Peer-ReviewedThe behavior of chromosomes during meiosis has been likened to a middle school dance, where partners find one another, form couples that move about and trade information, and then separate to opposite sides of the dance...
- 5From: PLoS Genetics. (Vol. 4, Issue 9) Peer-ReviewedHarlequin Ichthyosis (HI) is a severe and often lethal hyperkeratotic skin disease caused by mutations in the ABCA12 transport protein. In keratinocytes, ABCA12 is thought to regulate the transfer of lipids into small...
- 6From: PLoS Genetics. (Vol. 4, Issue 9) Peer-ReviewedCompylobacter jejuni is the leading cause of bacterial gastro-enteritis in the developed world. It is thought to infect 2-3 million people a year in the US alone, at a cost to the economy in excess of US $4 billion. C....
- 7From: PLoS Genetics. (Vol. 4, Issue 9) Peer-ReviewedDot1 is an evolutionarily conserved histone methyltransferase specific for lysine 79 of histone H3 (H3K79). In Saccharomyces cerevisiae, Dot1-mediated H3K79 methylation is associated with telomere silencing, meiotic...
- 8From: PLoS Genetics. (Vol. 4, Issue 9) Peer-ReviewedThe propensity of segmental duplications (SDs) to promote genomic instability is of increasing interest since their involvement in numerous human genomic diseases and cancers was revealed. However, the mechanism(s)...
- 9From: PLoS Genetics. (Vol. 4, Issue 9) Peer-ReviewedIn the last two decades, mitochondrial DNA (mtDNA) and the non-recombining portion of the Y chromosome (NRY) have been extensively used in order to measure the maternally and paternally inherited genetic structure of...
- 10From: PLoS Genetics. (Vol. 4, Issue 9) Peer-ReviewedTwo eukaryotic pathways for processing double-strand breaks (DSBs) as crossovers have been described, one dependent on the MutL homologs Mlh1 and Mlh3, and the other on the structure-specific endonuclease Mus81....
- 11From: PLoS Genetics. (Vol. 4, Issue 9) Peer-ReviewedAs genetic information is transmitted through successive generations, it passes between pluripotent cells in the early embryo and germ cells in the developing foetus and adult animal. Tex19.1 encodes a protein of...
- 12From: PLoS Genetics. (Vol. 4, Issue 9) Peer-ReviewedChromosome movements are a general feature of mid-prophase of meiosis. In budding yeast, meiotic chromosomes exhibit dynamic movements, led by nuclear envelope (NE)-associated telomeres, throughout the zygotene and...
- 13From: PLoS Genetics. (Vol. 4, Issue 9) Peer-ReviewedThe neural crest (NC) is a population of embryonic stem cells that gives rise to numerous cell types, including the glia and neurons of the peripheral and enteric nervous systems and the melanocytes of the skin and...
- 14From: PLoS Genetics. (Vol. 4, Issue 9) Peer-ReviewedThe TAR DNA-binding protein 43 (TDP-43) has been identified as the major disease protein in amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration with ubiquitin inclusions (FTLD-U), defining a novel...
- 15From: PLoS Genetics. (Vol. 4, Issue 9) Peer-ReviewedSox10 is a dynamically regulated transcription factor gene that is essential for the development of neural crest-derived and oligodendroglial populations. Developmental genes often require multiple regulatory sequences...
- 16From: PLoS Genetics. (Vol. 4, Issue 9) Peer-ReviewedChampagne coat color in horses is controlled by a single, autosomal-dominant gene (CH). The phenotype produced by this gene is valued by many horse breeders, but can be difficult to distinguish from the effect produced...
- 17From: PLoS Genetics. (Vol. 4, Issue 9) Peer-ReviewedThe levels of methyl-CpG-binding protein 2 (MeCP2) are critical for normal post-natal development and function of the nervous system. Loss of function of MeCP2, a transcriptional regulator involved in chromatin...
- 18From: PLoS Genetics. (Vol. 4, Issue 9) Peer-ReviewedPolycomb-group (PcG) and Trithorax-group proteins together form a maintenance machinery that is responsible for stable heritable states of gene activity. While the best-studied target genes are the Hox genes of the...
- 19From: PLoS Genetics. (Vol. 4, Issue 9) Peer-ReviewedThe synaptonemal complex (SC) is an intricate structure that forms between homologous chromosomes early during the meiotic prophase, where it mediates homolog pairing interactions and promotes the formation of genetic...
- 20From: PLoS Genetics. (Vol. 4, Issue 9) Peer-ReviewedUnlike most bacteria, Vibrio cholerae harbors two distinct, nonhomologous circular chromosomes (chromosome I and II). Many features of chromosome II are plasmid-like, which raised questions concerning its chromosomal...