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- Search Terms:ISSN: 15537390AndISSN: 15537404AndVolume Number: 4AndIssue Number: 8AndStart Page: e1000139AndDate: 2008 Revise Search
- 1From: PLoS Genetics. (Vol. 4, Issue 8) Peer-ReviewedMaintenance of physiologic phosphate balance is of crucial biological importance, as it is fundamental to cellular function, energy metabolism, and skeletal mineralization. Fibroblast growth factor-23 (FGF-23) is a...
- 2From: PLoS Genetics. (Vol. 4, Issue 8) Peer-ReviewedWe use high-density single nucleotide polymorphism (SNP) genotyping microarrays to demonstrate the ability to accurately and robustly determine whether individuals are in a complex genomic DNA mixture. We first develop...
- 3From: PLoS Genetics. (Vol. 4, Issue 8) Peer-ReviewedWhole-genome sequencing is a powerful technique for obtaining the reference sequence information of multiple organisms. Its use can be dramatically expanded to rapidly identify genomic variations, which can be linked...
- 4From: PLoS Genetics. (Vol. 4, Issue 8) Peer-ReviewedThe thymus is a vertebrate-specific organ where T lymphocytes are generated. Genetic programs that lead to thymus development are incompletely understood. We previously screened ethylnitrosourea-induced medaka mutants...
- 5From: PLoS Genetics. (Vol. 4, Issue 8) Peer-ReviewedThe presence of spliceosomal introns in eukaryotes raises a range of questions about genomic evolution. Along with the fundamental mysteries of introns' initial proliferation and persistence, the evolutionary forces...
- 6From: PLoS Genetics. (Vol. 4, Issue 8) Peer-ReviewedGenome-wide scans for positively selected genes (PSGs) in mammals have provided insight into the dynamics of genome evolution, the genetic basis of differences between species, and the functions of individual genes....
- 7From: PLoS Genetics. (Vol. 4, Issue 8) Peer-ReviewedChanges in gene regulation may be important in evolution. However, the evolutionary properties of regulatory mutations are currently poorly understood. This is partly the result of an incomplete annotation of functional...
- 8From: PLoS Genetics. (Vol. 4, Issue 8) Peer-ReviewedRecently diverged species typically have incomplete reproductive barriers, allowing introgression of genetic material from one species into the genomic background of the other. The role of natural selection in...
- 9From: PLoS Genetics. (Vol. 4, Issue 8) Peer-ReviewedChronic exposure to inducers of DNA base oxidation and single and double strand breaks contribute to tumorigenesis. In addition to the genetic changes caused by this DNA damage, such tumors often contain epigenetically...
- 10From: PLoS Genetics. (Vol. 4, Issue 8) Peer-ReviewedAnalysis of cells in culture has made substantial contributions to biological research. The versatility and scale of in vitro manipulation and new applications such as high-throughput gene silencing screens ensure the...
- 11From: PLoS Genetics. (Vol. 4, Issue 8) Peer-Reviewed
Divergent evolution of CHD3 proteins resulted in MOM1 refining epigenetic control in vascular plants
Arabidopsis MOM1 is required for the heritable maintenance of transcriptional gene silencing (TGS). Unlike many other silencing factors, depletion of MOM1 evokes transcription at selected loci without major changes in... - 12From: PLoS Genetics. (Vol. 4, Issue 8) Peer-ReviewedThere is an interesting overlap of function in a wide range of organisms between genes that modulate the stress responses and those that regulate aging phenotypes and, in some cases, lifespan. We have therefore screened...
- 13From: PLoS Genetics. (Vol. 4, Issue 8) Peer-ReviewedIn budding yeast, intragenic histone modification is linked with transcriptional elongation through the conserved regulator Paf1C. To investigate Paf1C-related function in higher eukaryotes, we analyzed the effects of...
- 14From: PLoS Genetics. (Vol. 4, Issue 8) Peer-ReviewedThe nucleolus has shown to be integral for many processes related to cell growth and proliferation. Stem cells in particular are likely to depend upon nucleolus-based processes to remain in a proliferatioe state. A...
- 15From: PLoS Genetics. (Vol. 4, Issue 8) Peer-ReviewedThere is much interest in characterizing the variation in a human individual, because this may elucidate what contributes significantly to a person's phenotype, thereby enabling personalized genomics. We focus here on...
- 16From: PLoS Genetics. (Vol. 4, Issue 8) Peer-ReviewedHundreds of genes show aberrant DNA hypermethylation in cancer, yet little is known about the causes of this hypermethylation. We identified RIL as a frequent methylation target in cancer. In search for factors that...
- 17From: PLoS Genetics. (Vol. 4, Issue 8) Peer-ReviewedThe abundance and identity of functional variation segregating in natural populations is paramount to dissecting the molecular basis of quantitative traits as well as human genetic diseases. Genome sequencing of...
- 18From: PLoS Genetics. (Vol. 4, Issue 8) Peer-ReviewedAt the imprinted Rasgrf1 locus in mouse, a cis-acting sequence controls DNA methylation at a differentially methylated domain (DMD). While characterizing epigenetic marks over the DMD, we observed that DNA and H3K27...
- 19From: PLoS Genetics. (Vol. 4, Issue 8) Peer-ReviewedThe phytochromes (phyA to phyE) are a major plant photoreceptor family that regulate a diversity of developmental processes in response to light. The N-terminal 651-amino acid domain of phyE (N651), which binds an open...
- 20From: PLoS Genetics. (Vol. 4, Issue 8) Peer-ReviewedFunctional redundancy limits detailed analysis of genes in many organisms. Here, we report a method to efficiently overcome this obstacle by combining gene expression data with analysis of gene-indexed mutants. Using a...