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- 1From: PLoS Genetics. (Vol. 4, Issue 7) Peer-ReviewedWe like to think that our genome is rock-solid, that it is dependable, there for us when we need it. The truth is far from that. By fits and starts, our species' collective genome is undulating, reshaping itself with...
- 2From: PLoS Genetics. (Vol. 4, Issue 7) Peer-ReviewedPoly-ubiquitination of target proteins typically marks them for destruction via the proteasome and provides an essential mechanism for the dynamic control of protein levels. The El ubiquitin-activating enzyme lies at...
- 3From: PLoS Genetics. (Vol. 4, Issue 7) Peer-ReviewedChromatin structure plays an important role in modulating the accessibility of genomic DNA to regulatory proteins in eukaryotic cells. We performed an integrative analysis on dozens of recent datasets generated by...
- 4From: PLoS Genetics. (Vol. 4, Issue 7) Peer-ReviewedFood deprivation is known to affect physiology and behavior. Changes that occur could be the result of the organism's monitoring of internal and external nutrient availability. In C. elegans, male mating is dependent on...
- 5From: PLoS Genetics. (Vol. 4, Issue 7) Peer-ReviewedTranscriptional repression of ribosomal components and tRNAs is coordinately regulated in response to a wide variety of environmental stresses. Part of this response involves the convergence of different nutritional and...
- 6From: PLoS Genetics. (Vol. 4, Issue 7) Peer-ReviewedThe sterol regulatory element-binding protein (SREBP) family member SREBP1 is a critical transcriptional regulator of cholesterol and fatty acid metabolism and has been implicated in insulin resistance, diabetes, and...
- 7From: PLoS Genetics. (Vol. 4, Issue 7) Peer-ReviewedExplaining how interactions between genes and the environment influence social behavior is a fundamental research goal, yet there is limited relevant information for species exhibiting natural variation in social...
- 8From: PLoS Genetics. (Vol. 4, Issue 7) Peer-ReviewedPeople who begin daily smoking at an early age are at greater risk of long-term nicotine addiction. We tested the hypothesis that associations between nicotinic acetylcholine receptor (nAChR) genetic variants and...
- 9From: PLoS Genetics. (Vol. 4, Issue 7) Peer-ReviewedThe ability to perform large-scale, expression-based chemogenomics on whole adult organisms, as in invertebrate models (worm and fly), is highly desirable for a vertebrate model but its feasibility and potential has not...
- 10From: PLoS Genetics. (Vol. 4, Issue 7) Peer-ReviewedRegulation of cell cycle progression is fundamental to cell health and reproduction, and failures in this process are associated with many human diseases. Much of our knowledge of cell cycle regulators derives from...
- 11From: PLoS Genetics. (Vol. 4, Issue 7) Peer-ReviewedPLoS Genetics is three years old this month--a milestone worth celebrating! As we do, and as we recognize all who have helped us reach this point in time, we thought this would be a good opportunity to share with you a...
- 12From: PLoS Genetics. (Vol. 4, Issue 7) Peer-ReviewedThe loss of functional redundancy is the key process in the evolution of duplicated genes. Here we systematically assess the extent of functional redundancy among a large set of duplicated genes in Saccharomyces...
- 13From: PLoS Genetics. (Vol. 4, Issue 7) Peer-ReviewedGenome structure variation has profound impacts on phenotype in organisms ranging from microbes to humans, yet little is known about how natural selection acts on genome arrangement. Pathogenic bacteria such as Yersinia...
- 14From: PLoS Genetics. (Vol. 4, Issue 7) Peer-ReviewedIn 404 [Lep.sup.ob/ob] F2 progeny of a C57BL/6J (B6) x DBA/2J (DBA) intercross, we mapped a DBA-related quantitative trait locus (QTQ to distal Chr1 at 169.6 Mb, centered about D1 Mit110, for diabetes-related phenotypes...
- 15From: PLoS Genetics. (Vol. 4, Issue 7) Peer-ReviewedTesting one SNP at a time does not fully realise the potential of genome-wide association studies to identify multiple causal variants, which is a plausible scenario for many complex diseases. We show that simultaneous...
- 16From: PLoS Genetics. (Vol. 4, Issue 7) Peer-ReviewedGene class, ontology, or pathway testing analysis has become increasingly popular in microarray data analysis. Such approaches allow the integration of gene annotation databases, such as Gene Ontology and KEGG Pathway,...
- 17From: PLoS Genetics. (Vol. 4, Issue 7) Peer-ReviewedGenetic structure in the European American population reflects waves of migration and recent gene flow among different populations. This complex structure can introduce bias in genetic association studies. Using...
- 18From: PLoS Genetics. (Vol. 4, Issue 7) Peer-ReviewedMutations in human Exostosin genes (EXTs) confer a disease called Hereditary Multiple Exostoses (HME) that affects 1 in 50,000 among the general population. Patients with HME have a short stature and develop...
- 19From: PLoS Genetics. (Vol. 4, Issue 7) Peer-ReviewedSuccessful tumor development and progression involves the complex interplay of both pro- and anti-oncogenic signaling pathways. Genetic components balancing these opposing activities are likely to require tight...
- 20From: PLoS Genetics. (Vol. 4, Issue 7) Peer-ReviewedDosage compensation has been thought to be a ubiquitous property of sex chromosomes that are represented differently in males and females. The expression of most X-borne genes is equalized between XX females and XY...