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- Search Terms:ISSN: 15537390AndISSN: 15537404AndVolume Number: 4AndIssue Number: 6AndStart Page: e1000107AndDate: 2008 Revise Search
- 1From: PLoS Genetics. (Vol. 4, Issue 6) Peer-ReviewedThe MYC oncogene has been implicated in the regulation of up to thousands of genes involved in many cellular programs including proliferation, growth, differentiation, self-renewal, and apoptosis. MYC is thought to...
- 2From: PLoS Genetics. (Vol. 4, Issue 6) Peer-ReviewedSequence-specific binding by the human p53 master regulator is critical to its tumor suppressor activity in response to environmental stresses. p53 binds as a tetramer to two decameric half-sites separated by 0-13...
- 3From: PLoS Genetics. (Vol. 4, Issue 6) Peer-ReviewedBcl-w belongs to the prosurvival group of the Bcl-2 family, while the glutamate receptor [[delta]2 (Grid2) is an excitatory receptor that is specifically expressed in Purkinje cells, and required for Purkinje cell...
- 4From: PLoS Genetics. (Vol. 4, Issue 6) Peer-ReviewedRheumatoid arthritis (RA) is a chronic, systemic autoimmune disease affecting both joints and extra-articular tissues. Although some genetic risk factors for RA are well-established, most notably HLA-DRB1 and PTPN22,...
- 5From: PLoS Genetics. (Vol. 4, Issue 6) Peer-ReviewedPlants use the energy in sunlight for photosynthesis, but as a consequence are exposed to the toxic effect of UV radiation especially on DNA. The UV-induced lesions on DNA affect both transcription and replication and...
- 6From: PLoS Genetics. (Vol. 4, Issue 6) Peer-ReviewedThe ribosomal DNA (rDNA) genes of Saccharomyces cerevisiae are located in a tandem array of about 150 repeats. Using a diploid with markers flanking and within the rDNA array, we showed that low levels of DNA polymerase...
- 7From: PLoS Genetics. (Vol. 4, Issue 6) Peer-ReviewedParent-of-origin-dependent gene expression resulting from genomic imprinting plays an important role in modulating complex traits ranging from developmental processes to cognitive abilities and associated disorders....
- 8From: PLoS Genetics. (Vol. 4, Issue 6) Peer-ReviewedThe larval salivary gland of Drosophila melanogaster synthesizes and secretes glue glycoproteins that cement developing animals to a solid surface during metamorphosis. The steroid hormone 20-hydroxyecdysone (20E) is an...
- 9From: PLoS Genetics. (Vol. 4, Issue 6) Peer-ReviewedClose to 20 years ago, I was contacted by an Australian woman who was planning to map the locations of genes that are X-linked in humans in some odd Australian critters, the monotremes. These animals comprise a...
- 10From: PLoS Genetics. (Vol. 4, Issue 6) Peer-ReviewedNucleosome remodeling and covalent modifications of histones play fundamental roles in chromatin structure and function. However, much remains to be learned about how the action of ATP-dependent chromatin remodeling...
- 11From: PLoS Genetics. (Vol. 4, Issue 6) Peer-ReviewedEstrogen receptors (ER) are important regulators of metabolic diseases such as obesity and insulin resistance (IR). While ER[alpha] seems to have a protective role in such diseases, the function of ER[beta] is not...
- 12From: PLoS Genetics. (Vol. 4, Issue 6) Peer-ReviewedThe annotated genome sequences of prokaryotes seldom include overlapping genes encoded opposite each other by the same stretch of DNA. However, antisense transcription is becoming recognized as a widespread phenomenon...
- 13From: PLoS Genetics. (Vol. 4, Issue 6) Peer-ReviewedInvasive aspergillosis (IA) is a common and life-threatening infection in immunocompromised individuals. A number of environmental and epidemiologic risk factors for developing IA have been identified. However, genetic...
- 14From: PLoS Genetics. (Vol. 4, Issue 6) Peer-ReviewedThe proper temporal and spatial expression of genes during plant development is governed, in part, by the regulatory activities of various types of small RNAs produced by the different RNAi pathways. Here we report that...
- 15From: PLoS Genetics. (Vol. 4, Issue 6) Peer-ReviewedCharacterizing the functional overlap and mutagenic potential of different pathways of chromosomal double-strand break (DSB) repair is important to understand how mutations arise during cancer development and treatment....
- 16From: PLoS Genetics. (Vol. 4, Issue 6) Peer-ReviewedTo facilitate whole-genome association studies (WGAS), several high-density SNP genotyping arrays have been developed. Genetic coverage and statistical power are the primary benchmark metrics in evaluating the...
- 17From: PLoS Genetics. (Vol. 4, Issue 6) Peer-ReviewedSelenium is an important trace element that occurs in proteins in the form of selenocysteine (Sec) and in tRNAs in the form of selenouridine. Recent large-scale metagenomics projects provide an opportunity for...
- 18From: PLoS Genetics. (Vol. 4, Issue 6) Peer-ReviewedGenetic background effects underlie the penetrance of most genetically determined phenotypes, including human diseases. To explore how such effects can modify a mutant phenotype in a genetically tractable system, we...
- 19From: PLoS Genetics. (Vol. 4, Issue 6) Peer-ReviewedDNA methylation patterns are reprogrammed in primordial germ cells and in preimplantation embryos by demethylation and subsequent de novo methylation. It has been suggested that epigenetic reprogramming may be necessary...
- 20From: PLoS Genetics. (Vol. 4, Issue 6) Peer-ReviewedPlasmode is a term coined several years ago to describe data sets that are derived from real data but for which some truth is known. Omic techniques, most especially microarray and genomewide association studies, have...