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- Search Terms:ISSN: 15537390AndISSN: 15537404AndVolume Number: 4AndIssue Number: 5AndStart Page: e1000084AndDate: 2008 Revise Search
- 1From: PLoS Genetics. (Vol. 4, Issue 5) Peer-ReviewedPancreatobiliary cancers have among the highest mortality rates of any cancer type. Discovering the full spectrum of molecular genetic alterations may suggest new avenues for therapy. To catalogue genomic alterations,...
- 2From: PLoS Genetics. (Vol. 4, Issue 5) Peer-ReviewedWe conducted a multi-stage genome-wide association study of natural hair color in more than 10,000 men and women of European ancestry from the United States and Australia. An initial analysis of 528,173 single...
- 3From: PLoS Genetics. (Vol. 4, Issue 5) Peer-ReviewedGenome-wide gene expression profiling has been extensively used to generate biological hypotheses based on differential expression. Recently, many studies have used microarrays to measure gene expression levels across...
- 4From: PLoS Genetics. (Vol. 4, Issue 5) Peer-ReviewedSystemic lupus erythematosus (SLE) is a genetically complex disease with heterogeneous clinical manifestations. A polymorphism in the STAT4 gene has recently been established as a risk factor for SLE, but the...
- 5From: PLoS Genetics. (Vol. 4, Issue 5) Peer-ReviewedA newly arisen Y-chromosome can become established in one part of a species range by genetic drift or through the effects of selection on sexually antagonistic alleles. However, it is difficult to explain why it should...
- 6From: PLoS Genetics. (Vol. 4, Issue 5) Peer-ReviewedInducible and reversible regulation of gene expression is a powerful approach for uncovering gene function. We have established a general method to efficiently produce reversible and inducible gene knockout and rescue...
- 7From: PLoS Genetics. (Vol. 4, Issue 5) Peer-ReviewedAlthough the genotype-phenotypemap plays a central role both in Quantitative and Evolutionary Genetics, the formalization of a completely general and satisfactory model of genetic effects, particularly accounting for...
- 8From: PLoS Genetics. (Vol. 4, Issue 5) Peer-ReviewedGenome-wide scans of genetic variation can potentially provide detailed information on how modern humans colonized the world but require new methods of analysis. We introduce a statistical approach that uses Single...
- 9From: PLoS Genetics. (Vol. 4, Issue 5) Peer-ReviewedGenome mosaicism in temperate bacterial viruses (bacteriophages) is so great that it obscures their phylogeny at the genome level. However, the precise molecular processes underlying this mosaicism are unknown....
- 10From: PLoS Genetics. (Vol. 4, Issue 5) Peer-ReviewedThe functional consequences of missense variants in disease genes are difficult to predict. We assessed if gene expression profiles could distinguish between BRCA1 or BRCA2 pathogenic truncating and missense mutation...
- 11From: PLoS Genetics. (Vol. 4, Issue 5) Peer-ReviewedForward genetic screens in model organisms are an attractive means to identify those genes involved in any complex biological process, including neural circuit assembly. Although mutagenesis screens are readily...
- 12From: PLoS Genetics. (Vol. 4, Issue 5) Peer-ReviewedUnraveling the evolutionary forces responsible for variations of neutral substitution patterns among taxa or along genomes is a major issue for detecting selection within sequences. Mammalian genomes show large-scale...
- 13From: PLoS Genetics. (Vol. 4, Issue 5) Peer-ReviewedDihydropyridines (DHPs) are L-type calcium channel ([Ca.sub.v]1) blockers prescribed to treat several diseases including hypertension. [Ca.sub.v]1 channels normally exist in three states: a resting closed state, an open...
- 14From: PLoS Genetics. (Vol. 4, Issue 5) Peer-ReviewedIn eutherian mammals, embryonic growth and survival is dependent on the formation of the placenta, an organ that facilitates the efficient exchange of oxygen, nutrients, and metabolic waste between the maternal and...
- 15From: PLoS Genetics. (Vol. 4, Issue 5) Peer-ReviewedThere is considerable evidence that human genetic variation influences gene expression. Genome-wide studies have revealed that mRNA levels are associated with genetic variation in or close to the gene coding for those...
- 16From: PLoS Genetics. (Vol. 4, Issue 5) Peer-ReviewedThe marine bacterium Saccharophagus degradans strain 2-40 (Sde 2-40) is emerging as a vanguard of a recently discovered group of marine and estuarine bacteria that recycles complex polysaccharides. We report its...
- 17From: PLoS Genetics. (Vol. 4, Issue 5) Peer-ReviewedThe model plant species Arabidopsis thaliana is successful at colonizing land that has recently undergone human-mediated disturbance. To investigate the prehistoric spread of A. thaliana, we applied approximate Bayesian...
- 18From: PLoS Genetics. (Vol. 4, Issue 5) Peer-ReviewedIn Drosophila, dosage compensation augments X chromosome-linked transcription in males relative to females. This process is achieved by the Dosage Compensation Complex (DCC), which associates specifically with the male...
- 19From: PLoS Genetics. (Vol. 4, Issue 5) Peer-ReviewedIntroduction In placental mammals (eutherians), there exist three paralogous genes of the vascular endothelial growth factor (VEGF) receptor family, namely FLT1 (also named VEGFR1), KDR (also named FLK1 and VEGFR2),...
- 20From: PLoS Genetics. (Vol. 4, Issue 5) Peer-ReviewedDNA binding transcriptional activators play a central role in gene-selective regulation. In part, this is mediated by targeting local covalent modifications of histone tails. Transcriptional regulation has also been...