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- 1From: PLoS Computational Biology. (Vol. 4, Issue 5) Peer-ReviewedComputational analysis of neural systems is at its most useful when it uncovers principles that provide a unified account of phenomena across multiple scales and levels of description. Here we analyse a widely used...
- 2From: PLoS Computational Biology. (Vol. 4, Issue 5) Peer-ReviewedSequence database searches require accurate estimation of the statistical significance of scores. Optimal local sequence alignment scores follow Gumbel distributions, but determining an important parameter of the...
- 3From: PLoS Computational Biology. (Vol. 4, Issue 5) Peer-ReviewedOscillatory activity plays a critical role in regulating biological processes at levels ranging from subcellular, cellular, and network to the whole organism, and often involves a large number of interacting elements....
- 4From: PLoS Computational Biology. (Vol. 4, Issue 5) Peer-ReviewedBacteria are able to sense and respond to a variety of external stimuli, with responses that vary from stimuli to stimuli and from species to species. The best-understood is chemotaxis in the model organism Escherichia...
- 5From: PLoS Computational Biology. (Vol. 4, Issue 5) Peer-ReviewedMonitoring cholesterol levels is strongly recommended to identify patients at risk for myocardial infarction. However, clinical markers beyond "bad" and "good" cholesterol are needed to precisely predict individual...
- 6From: PLoS Computational Biology. (Vol. 4, Issue 5) Peer-ReviewedBeing a scientist entails a common set of characteristics. Admiring nature and having concern for social issues; possessing a strong academic background, team work abilities, honesty, discipline, skepticism,...
- 7From: PLoS Computational Biology. (Vol. 4, Issue 5) Peer-ReviewedIntroduction Carbohydrates are considered the third class of information-encoding biological macromolecules. "Glycomics," the scientific attempt to characterize and study carbohydrates, is a rapidly emerging branch...
- 8From: PLoS Computational Biology. (Vol. 4, Issue 5) Peer-ReviewedAs modeling of changes in backbone conformation still lacks a computationally efficient solution, we developed a discretisation of the conformational states accessible to the protein backbone similar to the successful...
- 9From: PLoS Computational Biology. (Vol. 4, Issue 5) Peer-ReviewedDespite similar computational approaches, there is surprisingly little interaction between the computational neuroscience and the systems biology research communities. In this review I reconstruct the history of the two...
- 10From: PLoS Computational Biology. (Vol. 4, Issue 5) Peer-ReviewedChemical synapses transmit information via the release of neurotransmitter-filled vesicles from the presynaptic terminal. Using computational modeling, we predict that the limited availability of neurotransmitter...