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- Search Terms:ISSN: 15491277AndISSN: 15491676AndVolume Number: 4AndIssue Number: 5AndStart Page: e180AndDate: 2007 Revise Search
- 1From: PLoS Medicine. (Vol. 4, Issue 5) Peer-ReviewedABSTRACT Background Spinocerebellar ataxia type 1 (SCA1) is a dominantly inherited neurodegenerative disorder characterized by progressive motor and cognitive dysfunction. Caused by an expanded polyglutamine tract in...
- 2From: PLoS Medicine. (Vol. 4, Issue 5) Peer-ReviewedABSTRACT Background Primigravid (PG) women are at risk for pregnancy-associated malaria (PAM). Multigravid (MG) women acquire protection against PAM; however, HIV infection impairs this protective response....
- 3From: PLoS Medicine. (Vol. 4, Issue 5) Peer-ReviewedIntroduction Armed conflict and HIV infection have had a profound impact on the societies of sub-Saharan Africa. The number of countries engaged in armed conflict has fluctuated, totalling 24 African states in 2004...
- 4From: PLoS Medicine. (Vol. 4, Issue 5) Peer-ReviewedABSTRACT Background The asymptomatic phase of HIV infection is characterised by a slow decline of peripheral blood [CD4.sup.+] T cells. Why this decline is slow is not understood. One potential explanation is that...
- 5From: PLoS Medicine. (Vol. 4, Issue 5) Peer-ReviewedABSTRACT Background Average profiles of salivary progesterone in women vary significantly at the inter- and intrapopulation level as a function of age and acute energetic conditions related to energy intake, energy...
- 6From: PLoS Medicine. (Vol. 4, Issue 5) Peer-ReviewedABSTRACT Background Hyperoxic ventilation (>21% [O.sub.2]) is widely used in medical practice for resuscitation, stroke intervention, and chronic supplementation. However, despite the objective of improving tissue...
- 7From: PLoS Medicine. (Vol. 4, Issue 5) Peer-ReviewedChronic obstructive pulmonary disease (COPD) is a major and increasing global health epidemic that has received insufficient attention from the health-care profession, governments, and the pharmaceutical industry. Urgent...
- 8From: PLoS Medicine. (Vol. 4, Issue 5) Peer-ReviewedThe article by Skene [1] has touched on an important topic in as far as global health research is concerned. Skene's barometer is certainly a critical contribution to the discourse in research ethics that could be used...
- 9From: PLoS Medicine. (Vol. 4, Issue 5) Peer-ReviewedABSTRACT Background Type 2 diabetes mellitus (T2DM) is characterized by defects in insulin secretion and action. Impaired glucose uptake in skeletal muscle is believed to be one of the earliest features in the...
- 10From: PLoS Medicine. (Vol. 4, Issue 5) Peer-ReviewedJulia Leimkugel, Abraham Hodgson, Abudulai Adams Forgor, Valentin Pflilger, Jean-Pierre Dangy, Tom Smith, Mark Achtman, Sebastien Gagneux, Gerd Pluschke In PLoS Medicine, volume 4, issue 3, doi:...
- 11From: PLoS Medicine. (Vol. 4, Issue 5) Peer-Reviewed"I am not interested in the bloody system! Why has he no food? Why is he starving to death?" Bob Geldof in The Observer, 1985 Activation and sustenance of immune responses during infection requires increased energy...
- 12From: PLoS Medicine. (Vol. 4, Issue 5) Peer-ReviewedABSTRACT Background New rapid syphilis tests permit simple and immediate diagnosis and treatment at a single clinic visit. We compared the cost-effectiveness, projected health outcomes, and annual cost of screening...
- 13From: PLoS Medicine. (Vol. 4, Issue 5) Peer-ReviewedProgress in the biomedical and clinical sciences has relied heavily on experimental animal research. However, the impact of other comparative disciplines such as evolutionary biology, and in particular its subdisciplines...
- 14From: PLoS Medicine. (Vol. 4, Issue 5) Peer-ReviewedThis article and editor's summary give the impression that the tuberculosis infection rate was actually reduced by opening windows [1]. A careful reading of the article clearly states that while ventilation rates were...
- 15From: PLoS Medicine. (Vol. 4, Issue 5) Peer-ReviewedABSTRACT Background Epidemic influenza causes serious mortality and morbidity in temperate countries each winter. Research suggests that schoolchildren are critical in the spread of influenza virus, while the elderly...
- 16From: PLoS Medicine. (Vol. 4, Issue 5) Peer-ReviewedInterest in evidence-based medicine (EBM) is growing in Italy, although its impact upon health policies and clinical practice is unclear. Rather than getting health information from unbiased evidence-based sources,...
- 17From: PLoS Medicine. (Vol. 4, Issue 5) Peer-ReviewedABSTRACT Background New prophylactic and therapeutic strategies to combat human infections with highly pathogenic avian influenza (HPAI) H5N1 viruses are needed. We generated neutralizing anti-H5N1 human monoclonal...
- 18From: PLoS Medicine. (Vol. 4, Issue 5) Peer-ReviewedRestrictions on United States federal funding have thrust state governments into a leadership role in funding and establishing standards for human embryonic stem cell (hESC) research. In 2004, California voters approved...
- 19From: PLoS Medicine. (Vol. 4, Issue 5) Peer-ReviewedThe PLoS Medicine Editors It is a favored pastime of medical editors and journalists (including ourselves) to criticize the World Health Organization (WHO) for, among other things, its "fossilized bureaucracy," its...
- 20From: PLoS Medicine. (Vol. 4, Issue 5) Peer-ReviewedABSTRACT Background Dysfunction of the immune system has been documented in many types of cancers. The precise nature and molecular basis of immune dysfunction in the cancer state are not well defined. Methods and...