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- Search Terms:ISSN: 15537390AndISSN: 15537404AndVolume Number: 4AndIssue Number: 4AndStart Page: e1000054AndDate: 2008 Revise Search
- 1From: PLoS Genetics. (Vol. 4, Issue 4) Peer-ReviewedA three-stage genome-wide association study recently identified single nucleotide polymorphisms (SNPs) in five loci (fibroblast growth receptor 2 (FGFR2), trinucleotide repeat containing 9 (TNRC9), mitogen-activated...
- 2From: PLoS Genetics. (Vol. 4, Issue 4) Peer-ReviewedThe Ninth Meeting on Human Genome Variation and Complex Genome Analysis was held in Sitges, Spain, in September 2007. This annual meeting, which originally focused on single nucleotide polymorphisms (SNPs), broadened...
- 3From: PLoS Genetics. (Vol. 4, Issue 4) Peer-ReviewedThe genetic control of common traits is rarely deterministic, with many genes contributing only to the chance of developing a given phenotype. This incomplete penetrance is poorly understood and is usually attributed to...
- 4From: PLoS Genetics. (Vol. 4, Issue 4) Peer-ReviewedThe class II trans-activator CIITA is a transcriptional co-activator required for the expression of Major Histocompatibility Complex (MHC) genes. Although the latter function is well established, the global target-gene...
- 5From: PLoS Genetics. (Vol. 4, Issue 4) Peer-ReviewedThe major histocompatibility complex (MHC) is one of the most extensively studied regions in the human genome because of the association of variants at this locus with autoimmune, infectious, and inflammatory diseases....
- 6From: PLoS Genetics. (Vol. 4, Issue 4) Peer-ReviewedGenotoxic agents that cause double-strand breaks (DSBs) often generate damage at the break termini. Processing enzymes, including nucleases and polymerases, must remove damaged bases and/or add new bases before...
- 7From: PLoS Genetics. (Vol. 4, Issue 4) Peer-ReviewedWe present the genome sequences of a new clinical isolate of the important human pathogen, Aspergillus fumigatus, A1163, and two closely related but rarely pathogenic species, Neosartorya fischeri NRRL181 and...
- 8From: PLoS Genetics. (Vol. 4, Issue 4) Peer-ReviewedThe Locus Control Region (LCR) requires intronic elements within [beta]-globin transgenes to direct high level expression at all ectopic integration sites. However, these essential intronic elements cannot be...
- 9From: PLoS Genetics. (Vol. 4, Issue 4) Peer-ReviewedA central question in genomic imprinting is how a specific sequence is recognized as the target for epigenetic marking. In both mammals and plants, imprinted genes are often associated with tandem repeats and...
- 10From: PLoS Genetics. (Vol. 4, Issue 4) Peer-ReviewedA variety of pathologies are associated with exposure to supraphysiological concentrations of essential metals and to nonessential metals and metalloids. The molecular mechanisms linking metal exposure to human...
- 11From: PLoS Genetics. (Vol. 4, Issue 4) Peer-ReviewedThe different environments that humans experience are likely to impact physiology and disease susceptibility. In order to estimate the magnitude of the impact of environment on transcript abundance, we examined gene...
- 12From: PLoS Genetics. (Vol. 4, Issue 4) Peer-ReviewedAngular head movements in vertebrates are detected by the three semicircular canals of the inner ear and their associated sensory tissues, the cristae. Bone morphogenetic protein 4 (Bmp4), a member of the Transforming...
- 13From: PLoS Genetics. (Vol. 4, Issue 4) Peer-ReviewedProgress in epigenetics has revealed mechanisms that can heritably regulate gene function independent of genetic alterations. Nevertheless, little is known about the role of epigenetics in evolution. This is due in part...
- 14From: PLoS Genetics. (Vol. 4, Issue 4) Peer-ReviewedCoenzyme Q (CoQ) is an essential electron carrier in the respiratory chain whose deficiency has been implicated in a wide variety of human mitochondrial disease manifestations. Its multi-step biosynthesis involves...
- 15From: PLoS Genetics. (Vol. 4, Issue 4) Peer-ReviewedCoordination between cellular metabolism and DNA replication determines when cells initiate division. It has been assumed that metabolism only plays a permissive role in cell division. While blocking metabolism arrests...
- 16From: PLoS Genetics. (Vol. 4, Issue 4) Peer-ReviewedLIN-35 is the sole C. elegans representative of the pocket protein family, which includes the mammalian Retinoblastoma protein pRb and its paralogs p107 and p130. In addition to having a well-established and central...
- 17From: PLoS Genetics. (Vol. 4, Issue 4) Peer-ReviewedA genome-wide association study was performed to identify genetic factors involved in susceptibility to psoriasis (PS) and psoriatic arthritis (PSA), inflammatory diseases of the skin and joints in humans. 223 PS cases...
- 18From: PLoS Genetics. (Vol. 4, Issue 4) Peer-ReviewedPopulation geneticists often study small numbers of carefully chosen loci, but it has become possible to obtain orders of magnitude for more data from overlaps of genome sequences. Here, we generate tens of millions of...