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- Search Terms:ISSN: 15537390AndISSN: 15537404AndVolume Number: 4AndIssue Number: 3AndStart Page: e1000016AndDate: 2008 Revise Search
- 1From: PLoS Genetics. (Vol. 4, Issue 3) Peer-ReviewedThe spatial organisation of the genome in the nucleus has a role in the regulation of gene expression. In vertebrates, chromosomal regions with low gene-density are located close to the nuclear periphery. Correlations...
- 2From: PLoS Genetics. (Vol. 4, Issue 3) Peer-ReviewedA fundamental problem in developmental biology concerns how multipotent precursors choose specific fates. Neural crest cells (NCCs) are multipotent, yet the mechanisms driving specific fate choices remain incompletely...
- 3From: PLoS Genetics. (Vol. 4, Issue 3) Peer-ReviewedMIP-T3 is a human protein found previously to associate with microtubules and the kinesin-interacting neuronal protein DISC1 (Disrupted-in-Schizophrenia 1), but whose cellular functions) remains unknown. Here we...
- 4From: PLoS Genetics. (Vol. 4, Issue 3) Peer-ReviewedAlthough DNA methylation patterns in somatic cells are thought to be relatively stable, they undergo dramatic changes during embryonic development, gametogenesis, and during malignant transformation. The enzymology of...
- 5From: PLoS Genetics. (Vol. 4, Issue 3) Peer-ReviewedGene expression data has been used in lieu of phenotype in both classical and quantitative genetic settings. These two disciplines have separate approaches to measuring and interpreting epistasis, which is the...
- 6From: PLoS Genetics. (Vol. 4, Issue 3) Peer-ReviewedWe have recently shown that hypomorphic Mre11 complex mouse mutants exhibit defects in the repair of meiotic double strand breaks (DSBs). This is associated with perturbation of synaptonemal complex morphogenesis,...
- 7From: PLoS Genetics. (Vol. 4, Issue 3) Peer-ReviewedInclusions in the brain containing [alpha]-synuclein are the pathological hallmark of Parkinson's disease, but how these inclusions are formed and how this links to disease is poorly understood. We have developed a C....
- 8From: PLoS Genetics. (Vol. 4, Issue 3) Peer-ReviewedThe large and diverse population of Latin America is potentially a powerful resource for elucidating the genetic basis of complex traits through admixture mapping. However, no genome-wide characterization of admixture...
- 9From: PLoS Genetics. (Vol. 4, Issue 3) Peer-ReviewedTranscription factors (TFs) regulate gene expression through specific interactions with short promoter elements. The same regulatory protein may recognize a variety of related sequences. Moreover, once they are detected...
- 10From: PLoS Genetics. (Vol. 4, Issue 3) Peer-ReviewedIt is now widely recognized that robustness is an inherent property of biological systems [1,2,3]. The contribution of close sequence homologs to genetic robustness against null mutations has been previously...
- 11From: PLoS Genetics. (Vol. 4, Issue 3) Peer-ReviewedAlthough numerous quantitative trait loci (QTL) influencing disease-related phenotypes have been detected through gene mapping and positional cloning, identification of the individual genes) and molecular pathways...
- 12From: PLoS Genetics. (Vol. 4, Issue 3) Peer-ReviewedWhole genome tiling arrays provide a high resolution platform for profiling of genetic, epigenetic, and gene expression polymorphisms. In this study we surveyed natural genomic variation in cytosine methylation among...
- 13From: PLoS Genetics. (Vol. 4, Issue 3) Peer-ReviewedWe combined gene divergence data, classical genetics, and phylogenetics to study the evolution of the mating-type chromosome in the filamentous ascomycete Neurospora tetrasperma. In this species, a large non-recombining...
- 14From: PLoS Genetics. (Vol. 4, Issue 3) Peer-ReviewedExpansion of the CGGNCCG-repeat tract in the 5' UTR of the FMR1 gene to >200 repeats leads to heterochromatinization of the promoter and gene silencing. This results in Fragile X syndrome (FXS), the most common...
- 15From: PLoS Genetics. (Vol. 4, Issue 3) Peer-ReviewedDespite the well-documented effects of plasma lipid lowering regimes halting atherosclerosis lesion development and reducing morbidity and mortality of coronary artery disease and stroke, the transcriptional response in...
- 16From: PLoS Genetics. (Vol. 4, Issue 3) Peer-ReviewedMigration of cells within epithelial sheets is an important feature of embryogenesis and other biological processes. Previous work has demonstrated a role for inositol 1,4,5-trisphosphate ([IP.sub.3])-mediated calcium...
- 17From: PLoS Genetics. (Vol. 4, Issue 3) Peer-ReviewedRuvAB and RuvABC complexes catalyze branch migration and resolution of Holliday junctions (HJs) respectively. In addition to their action in the last steps of homologous recombination, they process HJs made by...
- 18From: PLoS Genetics. (Vol. 4, Issue 3) Peer-ReviewedIn eukaryotes, neighboring genes can be packaged together in specific chromatin structures that ensure their coordinated expression. Examples of such multi-gene chromatin domains are well-documented, but a global view...
- 19From: PLoS Genetics. (Vol. 4, Issue 3) Peer-ReviewedThe skeleton is one of the most important features for the reconstruction of vertebrate phylogeny but few data are available to understand its molecular origin. In mammals the Runt genes are central regulators of...
- 20From: PLoS Genetics. (Vol. 4, Issue 3) Peer-ReviewedPSORSI (psoriasis susceptibility gene 1) is a major susceptibility locus for psoriasis. Several fine-mapping studies have highlighted a 300-kb candidate region of PSORS1 where multiple biologically plausible candidate...