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- Search Terms:ISSN: 15537390AndISSN: 15537404AndVolume Number: 4AndIssue Number: 2AndStart Page: e1000023AndDate: 2008 Revise Search
- 1From: PLoS Genetics. (Vol. 4, Issue 2) Peer-ReviewedThe extent and nature of epistatic interactions between mutations are issues of fundamental importance in evolutionary biology. However, they are difficult to study and their influence on adaptation remains poorly...
- 2From: PLoS Genetics. (Vol. 4, Issue 2) Peer-ReviewedSomite segmentation depends on a gene expression oscillator or clock in the posterior presomitic mesoderm (PSM) and on read-out machinery in the anterior PSM to convert the pattern of clock phases into a Somite pattern....
- 3From: PLoS Genetics. (Vol. 4, Issue 2) Peer-ReviewedHuman remodeling and spacing factor (RSF) consists of a heterodimer of Rsf-1 and h5NF2H, a counterpart of Drosophila ISWI. RSF possesses not only chromatin remodeling activity but also chromatin assembly activity in...
- 4From: PLoS Genetics. (Vol. 4, Issue 2) Peer-ReviewedGene duplication is a major driver of evolutionary divergence. In most vertebrates a single PAX6 gene encodes a transcription factor required for eye, brain, olfactory system, and pancreas development. In zebrafish,...
- 5From: PLoS Genetics. (Vol. 4, Issue 2) Peer-ReviewedIn eukaryotes, RNA polymerase II ([Pol.sub.II]) dependent gene expression requires accessory factors termed transcriptional coregulators. One coregulator that universally contributes to [Pol.sub.II]-dependent...
- 6From: PLoS Genetics. (Vol. 4, Issue 2) Peer-Reviewed
Alternative splicing regulation during C. elegans development: splicing factors as regulated targets
Alternative splicing generates protein diversity and allows for post-transcriptional gene regulation. Estimates suggest that 10% of the genes in Caenorhabdiiis elegans undergo alternative splicing. We constructed a... - 7From: PLoS Genetics. (Vol. 4, Issue 2) Peer-ReviewedA central question in evolutionary biology concerns the developmental processes by which new phenotypes arise. An exceptional example of evolutionary innovation is the single-celled seed trichome in Gossypium ("cotton...
- 8From: PLoS Genetics. (Vol. 4, Issue 2) Peer-ReviewedComparing gene expression profiles over many different conditions has led to insights that were not obvious from single experiments. In the same way, comparing patterns of natural selection across a set of ecologically...
- 9From: PLoS Genetics. (Vol. 4, Issue 2) Peer-ReviewedThe DNA damage checkpoint and the spindle assembly checkpoint (SAC) are two important regulatory mechanisms that respond to different lesions. The DNA damage checkpoint detects DNA damage, initiates protein kinase...
- 10From: PLoS Genetics. (Vol. 4, Issue 2) Peer-ReviewedThe localization of specific mRNAs can establish local protein gradients that generate and control the development of cellular asymmetries. While all evidence underscores the importance of the cytoskeleton in the...
- 11From: PLoS Genetics. (Vol. 4, Issue 2) Peer-ReviewedHistone deacetylases (HDACs) execute biological regulation through post-translational modification of chromatin and other cellular substrates. In humans, there are eleven HDACs, organized into three distinct...
- 12From: PLoS Genetics. (Vol. 4, Issue 2) Peer-ReviewedThe success of genome-wide association studies relies on much of the risk of common diseases being due to common genetic variants; but evidence for this is inconclusive. The results of published genome-wide association...
- 13From: PLoS Genetics. (Vol. 4, Issue 2) Peer-ReviewedMolybdenum (Mo) is an essential micronutrient for plants, serving as a cofactor for enzymes involved in nitrate assimilation, sulfite detoxification, abscisic acid biosynthesis, and purine degradation. Here we show that...
- 14From: PLoS Genetics. (Vol. 4, Issue 2) Peer-ReviewedThe recent development of whole genome association studies has lead to the robust identification of several loci involved in different common human diseases. Interestingly, some of the strongest signals of association...
- 15From: PLoS Genetics. (Vol. 4, Issue 2) Peer-ReviewedInfertility affects about one in six couples attempting pregnancy, with the man responsible in approximately half of the cases. Because the pathophysiology underlying azoospermia is not elucidated, most male infertility...
- 16From: PLoS Genetics. (Vol. 4, Issue 2) Peer-ReviewedWhen I invited Elaine Strass for an interview, I had no idea she was planning to retire in the coming year. Elaine has been the hidden force behind both the Genetics Society of America (GSA) and the American Society of...
- 17From: PLoS Genetics. (Vol. 4, Issue 2) Peer-ReviewedEvolutionary pressures due to variation in climate play an important role in shaping phenotypic variation among and within species and have been shown to influence variation in phenotypes such as body shape and size...
- 18From: PLoS Genetics. (Vol. 4, Issue 2) Peer-ReviewedThe relative proportion of additive and non-additive variation for complex traits is important in evolutionary biology, medicine, and agriculture. We address a long-standing controversy and paradox about the...
- 19From: PLoS Genetics. (Vol. 4, Issue 2) Peer-ReviewedSex differences in schizophrenia are well known, but their genetic basis has not been identified. We performed a genome-wide association scan for schizophrenia in an Ashkenazi Jewish population using DNA pooling. We...
- 20From: PLoS Genetics. (Vol. 4, Issue 2) Peer-ReviewedADAMT520 (A disintegrin-like and metalloprotease domain with thrombospondin type-1 motifs) is a member of a family of secreted metalloproteases that can process a variety of extracellular matrix (ECM) components and...