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- 1From: PLoS Pathogens. (Vol. 4, Issue 2) Peer-Reviewed
Novel insights into disseminated candidiasis: pathogenesis research and clinical experience converge
Candida spp. have become leading causes of lethal bloodstream infections in countries with advanced medical technology [1]. It is generally and correctly understood that disseminated candidiasis is "an opportunistic... - 2From: PLoS Pathogens. (Vol. 4, Issue 2) Peer-ReviewedBorrelia burgdorferi is remarkable for its ability to thrive in widely different environments due to its ability to infect various organisms. In comparison to enteric Gram-negative bacteria, these spirochetes have only...
- 3From: PLoS Pathogens. (Vol. 4, Issue 2) Peer-ReviewedTreatment of human cells with Type 1 interferons restricts HIV replication. Here we report that the tripartite motif protein TRIM22 is a key mediator. We used transcriptional profiling to identify cellular genes that...
- 4From: PLoS Pathogens. (Vol. 4, Issue 2) Peer-ReviewedThe outcome of malaria infection is determined, in part, by the balance of pro-inflammatory and regulatory immune responses. Failure to develop an effective pro-inflammatory response can lead to unrestricted parasite...
- 5From: PLoS Pathogens. (Vol. 4, Issue 2) Peer-ReviewedPathogens are exogenous agents capable of causing disease in susceptible organisms. In celiac sprue, a disease triggered by partially hydrolyzed gluten peptides in the small intestine, the offending immunotoxins cannot...
- 6From: PLoS Pathogens. (Vol. 4, Issue 2) Peer-ReviewedThe final stage of bacterial cell division requires the activity of one or more enzymes capable of degrading the layers of peptidoglycan connecting two recently developed daughter cells. Although this is a key step in...
- 7From: PLoS Pathogens. (Vol. 4, Issue 2) Peer-ReviewedMalaria starts with the infection of the liver of the host by Plasmodium sporozoites, the parasite form transmitted by infected mosquitoes. Sporozoites migrate through several hepatocytes by breaching their plasma...
- 8From: PLoS Pathogens. (Vol. 4, Issue 2) Peer-ReviewedCurrently, our understanding of mechanisms underlying cell-mediated immunity and particularly of mechanisms that promote robust T cell memory to respiratory viruses is incomplete. Interleukin (IL)-6 has recently...
- 9From: PLoS Pathogens. (Vol. 4, Issue 2) Peer-ReviewedThe TRIM family proteins share a conserved arrangement of three adjacent domains, an N-terminal RING domain, followed by one or two B-boxes and a coiled-coil, which constitutes the tripartite-motif for which the family...
- 10From: PLoS Pathogens. (Vol. 4, Issue 2) Peer-ReviewedInvasion of hepatocytes by Plasmodium sporozoites is a prerequisite for establishment of a malaria infection, and thus represents an attractive target for anti-malarial interventions. Still, the molecular mechanisms...