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- 1From: Nature Cell Biology. (Vol. 4, Issue 2) Peer-ReviewedAt a recent post-symposium reception, I was talking to one of the participants when the conversation drifted towards our scientific pedigrees, as so often happens. When I revealed the identity of my graduate advisor, the...
- 2From: Nature Cell Biology. (Vol. 4, Issue 2) Peer-ReviewedAuthor(s): François G. Gervais [1]; Roshni Singaraja [2]; Steven Xanthoudakis [1]; Claire-Anne Gutekunst [3]; Blair R. Leavitt [2]; Martina Metzler [2]; Abigail S. Hackam [2, 4]; John Tam [1]; John P. Vaillancourt [1];...
- 3From: Nature Cell Biology. (Vol. 4, Issue 2) Peer-ReviewedAuthor(s): Hideo Fujiwara [1, 6]; Masato Hasegawa [1, 5, 6, 7]; Naoshi Dohmae [2]; Akiko Kawashima [1]; Eliezer Masliah [3]; Matthew S. Goldberg [4]; Jie Shen [4]; Koji Takio [2]; Takeshi Iwatsubo (corresponding author)...
- 4From: Nature Cell Biology. (Vol. 4, Issue 2) Peer-ReviewedBetween 1920 and 1970, the Dow Jones Industrial Average rose and fell with the lengths of skirts in fashion magazines. As skirts became shorter, stock prices shot higher. Glamorous as this may sound, it does not imply...
- 5From: Nature Cell Biology. (Vol. 4, Issue 2) Peer-ReviewedAuthor(s): Stefano De Renzis [1]; Birte Sönnichsen [2]; Marino Zerial (corresponding author) [1] Early endosomes are multifunctional organelles that regulate membrane transport between the plasma membrane and various...
- 6From: Nature Cell Biology. (Vol. 4, Issue 2) Peer-ReviewedAuthor(s): Mara Kreishman-Deltrick [1]; Michael K. Rosen [1] Rearranging the actin cytoskeleton in response to signals is critical in many biological processes, including cell motility, maintenance of cell...
- 7From: Nature Cell Biology. (Vol. 4, Issue 2) Peer-ReviewedAuthor(s): Michael Tsang [1]; Robert Friesel [2]; Tetsuhiro Kudoh [1]; Igor B Dawid (corresponding author) [1] Fibroblast growth factors (FGFs) are members of a family of some 30 secreted proteins important in the...
- 8From: Nature Cell Biology. (Vol. 4, Issue 2) Peer-ReviewedAuthor(s): Thomas Simmen [5, 1, 6]; Stefan Höning [5, 2]; Ann Icking [3]; Ritva Tikkanen [3]; Walter Hunziker (corresponding author) [1, 4] Adaptors are heterotetrameric complexes that mediate the incorporation of...
- 9From: Nature Cell Biology. (Vol. 4, Issue 2) Peer-ReviewedAuthor(s): Daniel J. Lew [1] Cell shape and cell motility are governed by the dynamic behaviour of the actin cytoskeleton. Decades of intensive research into the factors controlling actin organization culminated...
- 10From: Nature Cell Biology. (Vol. 4, Issue 2) Peer-ReviewedMuch has been written about the benefits and pitfalls of the peer review process, and despite its shortcomings, no superior alternative has been found. No one would deny that the review process is crucial in improving...
- 11From: Nature Cell Biology. (Vol. 4, Issue 2) Peer-Reviewed[illus. 1] In Perlman et al . (Nature Cell Biol. 3, 708-714), figure 4b should be as above. DOI: 10.1038/ncb752...
- 12From: Nature Cell Biology. (Vol. 4, Issue 2) Peer-ReviewedIn eukaryotes, entry into M-phase of the cell cycle is induced by activation of cyclin B-Cdc2 kinase. At G2-phase, the activity of its inactivator, a member of the Wee1 family of protein kinases, exceeds that of its...
- 13From: Nature Cell Biology. (Vol. 4, Issue 2) Peer-ReviewedAuthor(s): Lilly Bourguignon [1]; Keng-hsueh Lan [2]; Patrick Singleton [1]; Shiaw-Yih Lin (corresponding author); Dihua Yu (corresponding author) [2]; Mien-Chie Hung (corresponding author) [2, 3] Reply Indeed, we...
- 14From: Nature Cell Biology. (Vol. 4, Issue 2) Peer-ReviewedEndoplasmic reticulum (ER)-associated protein degradation by the ubiquitin-proteasome system requires the dislocation of substrates from the ER into the cytosol. It has been speculated that a functional ubiquitin...
- 15From: Nature Cell Biology. (Vol. 4, Issue 2) Peer-ReviewedAuthor(s): Alison Schuldt Despite our increased understanding of the dynamic nature of the nucleus, and the heterogeneity of the suborganelles it contains, our knowledge of the factors they contain and the functions...
- 16From: Nature Cell Biology. (Vol. 4, Issue 2) Peer-ReviewedAuthor(s): Alison C. Lloyd [1] Many of us are familiar with the image of a senescent cell--large, flat cells that are metabolically active yet are arrested in the cell cycle and stain blue when tested for the...
- 17From: Nature Cell Biology. (Vol. 4, Issue 2) Peer-ReviewedMembrane proteins with transmembrane domains (TMDs) that contain polar residues exposed to the lipid bilayer are selectively sorted into multivesicular bodies (MVBs) and delivered to the yeast vacuole. Sorting of some,...
- 18From: Nature Cell Biology. (Vol. 4, Issue 2) Peer-ReviewedAuthor(s): Magda Deneka [1]; Peter van der Sluijs [1] All eukaryotic cells internalize cell-surface proteins and material from their environment by endocytosis. The pathway is used, amongst others, for the uptake of...
- 19From: Nature Cell Biology. (Vol. 4, Issue 2) Peer-ReviewedType I interferon (IFN) stimulates transcription through a heteromeric transcription factor that contains tyrosine-phosphorylated STAT2. We show that STAT2 recruits histone acetyltransferases (HAT) through its...
- 20From: Nature Cell Biology. (Vol. 4, Issue 2) Peer-ReviewedAuthor(s): Valerie Ferrier Huntington disease (HD) is caused by mutations in the huntingtin gene. Mutant Huntingtin protein (Htt) with expanded polyglutamine repeats forms aggregates in diseased brains. It has been...