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- 1From: PLoS Pathogens. (Vol. 4, Issue 12) Peer-ReviewedThe Gram-positive bacterium Staphylococcus aureus, similar to other pathogens, binds human complement regulators Factor H and Factor H related protein 1 (FHR-1) from human serum. Here we identify the secreted protein Sbi...
- 2From: PLoS Pathogens. (Vol. 4, Issue 12) Peer-ReviewedPoxviruses subvert the host immune response by producing immunomodulatory proteins, including a complement regulatory protein. Ectromelia virus provides a mouse model for smallpox where the virus and the host's immune...
- 3From: PLoS Pathogens. (Vol. 4, Issue 12) Peer-ReviewedThe NSP-interacting kinase (NIK) receptor-mediated defense pathway has been identified recently as a virulence target of the geminivirus nuclear shuttle protein (NSP). However, the NIK1-NSP interaction does not fit into...
- 4From: PLoS Pathogens. (Vol. 4, Issue 12) Peer-ReviewedApoptosis plays an important role in the pathogenesis of reovirus encephalitis. Reovirus outer-capsid protein [mu]1, which functions to penetrate host cell membranes during viral entry, is the primary regulator of...
- 5From: PLoS Pathogens. (Vol. 4, Issue 12) Peer-ReviewedDengue virus (DENV) is an enveloped RNA virus that causes the most common arthropod-borne infection worldwide. The mechanism by which DENV infects the host cell remains unclear. In this work, we used live-cell imaging...
- 6From: PLoS Pathogens. (Vol. 4, Issue 12) Peer-ReviewedPatients with HIV-1 often present with a wide range of hematopoietic abnormalities, some of which may be due to the presence of opportunistic infections and to therapeutic drug treatments. However, many of these...
- 7From: PLoS Pathogens. (Vol. 4, Issue 12) Peer-ReviewedMitochondrial processing peptidases are heterodimeric enzymes ([alpha]/[beta]MPP) that play an essential role in mitochondrial biogenesis by recognizing and cleaving the targeting presequences of nuclear-encoded...
- 8From: PLoS Pathogens. (Vol. 4, Issue 12) Peer-ReviewedThe matrix (M) proteins of rhabdoviruses are multifunctional proteins essential for virus maturation and budding that also regulate the expression of viral and host proteins. We have solved the structures of M from the...
- 9From: PLoS Pathogens. (Vol. 4, Issue 12) Peer-ReviewedClostridium botulinum neurotoxin (BoNT) causes flaccid paralysis by disabling synaptic exocytosis. Intoxication requires the tri-modular protein to undergo conformational changes in response to pH and redox gradients...
- 10From: PLoS Pathogens. (Vol. 4, Issue 12) Peer-ReviewedHost immune responses against infectious pathogens exert strong selective pressures favouring the emergence of escape mutations that prevent immune recognition. Escape mutations within or flanking functionally conserved...