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- 1From: PLoS Genetics. (Vol. 4, Issue 11) Peer-ReviewedUnlike other monoamine neurotransmitters, the mechanism by which the brain's histamine content is regulated remains unclear. In mammals, vesicular monoamine transporters (VMATs) are expressed exclusively in neurons and...
- 2From: PLoS Genetics. (Vol. 4, Issue 11) Peer-ReviewedAcetylation of histone H3 lysine 56 is a covalent modification best known as a mark of newly replicated chromatin, but it has also been linked to replication-independent histone replacement. Here, we measured H3K56ac...
- 3From: PLoS Genetics. (Vol. 4, Issue 11) Peer-ReviewedInsects exposed to pesticides undergo strong natural selection and have developed various adaptive mechanisms to survive. Resistance to pyrethroid insecticides in the malaria vector Anopheles gambiae is receiving...
- 4From: PLoS Genetics. (Vol. 4, Issue 11) Peer-ReviewedOlfactory receptors (ORs), which are involved in odorant recognition, form the largest mammalian protein superfamily. The genomic content of OR genesis considerably reduced in humans, as reflected by the relatively...
- 5From: PLoS Genetics. (Vol. 4, Issue 11) Peer-ReviewedThe kinetochore is a protein complex that assembles on centromeric DNA to mediate chromosome-microtubule interaction. Most eukaryotic cells form the spindle and establish kinetochore-microtubule interaction during...
- 6From: PLoS Genetics. (Vol. 4, Issue 11) Peer-ReviewedMutation rate varies greatly between nucleotide sites of the human genome and depends both on the global genomic location and the local sequence context of a site. In particular, CpG context elevates the mutation rate...
- 7From: PLoS Genetics. (Vol. 4, Issue 11) Peer-ReviewedSmall RNAs targeted to gene promoters in human cells have been shown to modulate both transcriptional gene suppression and activation. However, the mechanism involved in transcriptional activation has remained poorly...
- 8From: PLoS Genetics. (Vol. 4, Issue 11) Peer-ReviewedAllantoin is the end product of purine catabolism in all mammals except humans, great apes, and one breed of dog, the Dalmatian. Humans and Dalmatian dogs produce uric acid during purine degradation, which leads to...
- 9From: PLoS Genetics. (Vol. 4, Issue 11) Peer-ReviewedAt least 25 inherited disorders in humans result from microsatellite repeat expansion. Dramatic variation in repeat instability occurs at different disease loci and between different tissues; however, cis-elements and...
- 10From: PLoS Genetics. (Vol. 4, Issue 11) Peer-ReviewedPRODH, encoding proline oxidase (POX), has been associated with schizophrenia through linkage, association, and the 22q11 deletion syndrome (Velo-Cardio-Facial syndrome). Here, we show in a family-based sample that...
- 11From: PLoS Genetics. (Vol. 4, Issue 11) Peer-ReviewedPolyploidy has had a considerable impact on the evolution of many eukaryotes, especially angiosperms. Indeed, most--if not all--angiosperms have experienced at least one round of polyploidy during the course of their...
- 12From: PLoS Genetics. (Vol. 4, Issue 11) Peer-ReviewedThe survival motor neuron (SMN) protein, the determining factor for spinal muscular atrophy (SMA), is complexed with a group of proteins in human cells. Gemin3 is the only RNA helicase in the SMN complex. Here, we...
- 13From: PLoS Genetics. (Vol. 4, Issue 11) Peer-ReviewedIntroduction Gene regulatory sequences have been investigated and/or proposed to be important targets of natural selection during animal evolution [1-14]. However, much controversy has been generated by the...
- 14From: PLoS Genetics. (Vol. 4, Issue 11) Peer-ReviewedNatural killer (NK) cells play an important role in the detection and elimination of tumors and virus-infected cells by the innate immune system. Human NK cells use cell surface receptors (KIR) for class I MHC to sense...
- 15From: PLoS Genetics. (Vol. 4, Issue 11) Peer-ReviewedThe fission yeast Schizosaccharomyces pombe Recl2 protein, the homolog of Spol1 in other organisms, initiates meiotic recombination by creating DNA double-strand breaks (DSBs) and becoming covalently linked to the DNA...
- 16From: PLoS Genetics. (Vol. 4, Issue 11) Peer-ReviewedThe rapidly evolving field of metabolomics aims at a comprehensive measurement of ideally all endogenous metabolites in a cell or body fluid. It thereby provides a functional readout of the physiological state of the...
- 17From: PLoS Genetics. (Vol. 4, Issue 11) Peer-ReviewedDishevelled (Dvl) proteins are important signaling components of both the canonical [beta]-catenin/Wnt pathway, which controls cell proliferation and patterning, and the planar cell polarity (PCP) pathway, which...
- 18From: PLoS Genetics. (Vol. 4, Issue 11) Peer-ReviewedSubtelomeric DNA in budding yeasts, like metazoan heterochromatin, is gene poor, repetitive, transiently silenced, and highly dynamic. The rapid evolution of subtelomeric regions is commonly thought to arise from...
- 19From: PLoS Genetics. (Vol. 4, Issue 11) Peer-ReviewedNutrient availability is an important environmental variable during development that has significant effects on the metabolism, health, and viability of an organism. To understand these interactions for the nutrient...
- 20From: PLoS Genetics. (Vol. 4, Issue 11) Peer-ReviewedSmall molecules have been shown to be potent and selective probes to understand cell physiology. Here, we show that imidazo[1,2-o]pyridines and imidazo[1,2-a]pyrimidines compose a class of compounds that target...