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- Search Terms:ISSN: 1553734XAndISSN: 15537358AndVolume Number: 4AndIssue Number: 11AndStart Page: e1000224AndDate: 2008 Revise Search
- 1From: PLoS Computational Biology. (Vol. 4, Issue 11) Peer-ReviewedLive-cell imaging by light microscopy has demonstrated that all cells are spatially and temporally organized. Quantitative, computational image analysis is an important part of cellular imaging, providing both enriched...
- 2From: PLoS Computational Biology. (Vol. 4, Issue 11) Peer-ReviewedResponse of cells to changing environmental conditions is governed by the dynamics of intricate biomolecular interactions. It may be reasonable to assume, proteins being the dominant macromolecules that carry out...
- 3From: PLoS Computational Biology. (Vol. 4, Issue 11) Peer-ReviewedThe reconstruction of ancestral genome architectures and gene orders from homologies between extant species is a long-standing problem, considered by both cytogeneticists and bioinformaticians. A comparison of the two...
- 4From: PLoS Computational Biology. (Vol. 4, Issue 11) Peer-ReviewedThere is evidence that biological synapses have a limited number of discrete weight states. Memory storage with such synapses behaves quite differently from synapses with unbounded, continuous weights, as old memories...
- 5From: PLoS Computational Biology. (Vol. 4, Issue 11) Peer-ReviewedHIV avoids elimination by cytotoxic T-lymphocytes (CTLs) through the evolution of escape mutations. Although there is mounting evidence that these escape pathways are broadly consistent among individuals with similar...
- 6From: PLoS Computational Biology. (Vol. 4, Issue 11) Peer-ReviewedIntroduction ChIP-chip, chromatin immunoprecipitation combined with DNA microarrays, is a widely used assay for DNA-protein binding and chromatin plasticity, which are of fundamental interest for the understanding of...
- 7From: PLoS Computational Biology. (Vol. 4, Issue 11) Peer-ReviewedProteins interact in complex protein-protein interaction (PPI) networks whose topological properties--such as scale-free topology, hierarchical modularity, and dissortativity--have suggested models of network evolution....
- 8From: PLoS Computational Biology. (Vol. 4, Issue 11) Peer-ReviewedEmbryonic development is defined by the hierarchical dynamical process that translates genetic information (genotype) into a spatial gene expression pattern (phenotype) providing the positional information for the...
- 9From: PLoS Computational Biology. (Vol. 4, Issue 11) Peer-ReviewedThe assumption that RNA can be readily classified into either protein-coding or non-proteincoding categories has pervaded biology for close to 50 years. Until recently, discrimination between these two categories was...
- 10From: PLoS Computational Biology. (Vol. 4, Issue 11) Peer-ReviewedIt is now recognized that molecular circuits with positive feedback can induce two different gene expression states (bistability) under the very same cellular conditions. Whether, and how, cells make use of the...