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- 1From: PLoS Medicine. (Vol. 4, Issue 11) Peer-ReviewedBackground to the debate: In 2004, the United States Food and Drug Administration approved a radiofrequency identification (RFID) device that is implanted under the skin of the upper arm of patients and that stores the...
- 2From: PLoS Medicine. (Vol. 4, Issue 11) Peer-ReviewedBackground The Roll Back Malaria strategy recommends a combination of interventions for malaria control. Zanzibar implemented artemisinin-based combination therapy (ACT) for uncomplicated malaria in late 2003 and...
- 3From: PLoS Medicine. (Vol. 4, Issue 11) Peer-ReviewedThis is the second of three articles in the November 2007 issue on developing new drug treatments for tuberculosis. Current Treatment for Tuberculosis and Research Agenda The standard preferred regimen for the...
- 4From: PLoS Medicine. (Vol. 4, Issue 11) Peer-ReviewedBackground Cause-of-death data for many developing countries are not available. Information on deaths in hospital by cause is available in many low- and middle-income countries but is not a representative sample of...
- 5From: PLoS Medicine. (Vol. 4, Issue 11) Peer-ReviewedA Policy Forum published in this month's PLoS Medicine highlights an issue that the PLoS Medicine editors have often debated: when research takes place within the context of clinical care, how can we distinguish which...
- 6From: PLoS Medicine. (Vol. 4, Issue 11) Peer-ReviewedBackground Although advances in rehydration therapy have made cholera a treatable disease with low case-fatality in settings with appropriate medical care, cholera continues to impose considerable mortality in the...
- 7From: PLoS Medicine. (Vol. 4, Issue 11) Peer-ReviewedMore than half of the world's deaths pass by undocumented as to cause [1]. Whilst the appropriate focus of health services may well be the care of the living, consistent and reliable cause-of-death data also constitute...
- 8From: PLoS Medicine. (Vol. 4, Issue 11) Peer-ReviewedBackground Mild cognitive impairment (MCI) refers to a transitional zone between normal ageing and dementia. Despite the uncertainty regarding the definition of MCI as a clinical entity, clinical trials have been...
- 9From: PLoS Medicine. (Vol. 4, Issue 11) Peer-ReviewedBackground Surrogate markers of protective immunity to malaria in humans are needed to rationalize malaria vaccine discovery and development. In an effort to identify such markers, and thereby provide a clue to the...
- 10From: PLoS Medicine. (Vol. 4, Issue 11) Peer-ReviewedBackground Cause of death data are a critical input to formulating good public health policy. In the absence of reliable vital registration data, information collected after death from household members, called...
- 11From: PLoS Medicine. (Vol. 4, Issue 11) Peer-ReviewedThis is the third of three articles in the November 2007 issue on developing new drug treatments for tuberculosis. The Pressing Need for MDR-TB Clinical Trials Drug-resistant strains of Mycobacterium tuberculosis...
- 12From: PLoS Medicine. (Vol. 4, Issue 11) Peer-ReviewedWe live in an age of evidence-based medicine [1], and with good reason. It is important to be able to evaluate the likely impact of various interventions, and it is no longer acceptable to practice health care on the...
- 13From: PLoS Medicine. (Vol. 4, Issue 11) Peer-ReviewedWhat Is Therapeutic Misconception? For over three decades, bioethics scholarship and research ethics guidelines have identified concerns about the boundaries between research and standard clinical care [1,2]....
- 14From: PLoS Medicine. (Vol. 4, Issue 11) Peer-ReviewedThis is the first of three articles in the November 2007 issue on developing new drug treatments for tuberculosis. Early stage drug discovery is a key bottleneck in the pipeline to find novel drugs for tuberculosis...
- 15From: PLoS Medicine. (Vol. 4, Issue 11) Peer-ReviewedAlthough the threat of pandemic influenza, spawned by continuing avian influenza A (H5N1) epidemics, has dropped off the front pages, concern among experts continues to grow. At the end of 2005, only 17 countries had...
- 16From: PLoS Medicine. (Vol. 4, Issue 11) Peer-ReviewedDisease Burden Cholera is a diarrhoeal disease caused by Vibrio cholerae O1 and O139, transmitted through the faeco-oral route. The disease occurs in outbreaks but can establish itself permanently. The full impact of...
- 17From: PLoS Medicine. (Vol. 4, Issue 11) Peer-ReviewedBackground Hyperparathyroidism (HPT) is a common endocrine disorder with incompletely understood etiology, characterized by enlarged hyperactive parathyroid glands and increased serum concentrations of parathyroid...
- 18From: PLoS Medicine. (Vol. 4, Issue 11) Peer-ReviewedBackground Little is known about the long-term drug costs associated with treating AIDS in developing countries. Brazil's AIDS treatment program has been cited widely as the developing world's largest and most...
- 19From: PLoS Medicine. (Vol. 4, Issue 11) Peer-ReviewedBackground While ethnic disparities in health and health care are increasing, evidence on how to enhance quality of care and reduce inequalities remains limited. Despite growth in the scope and application of...