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- Search Terms:ISSN: 15537390AndISSN: 15537404AndVolume Number: 4AndIssue Number: 10AndStart Page: e1000225AndDate: 2008 Revise Search
- 1From: PLoS Genetics. (Vol. 4, Issue 10) Peer-ReviewedRecent studies have detailed a remarkable degree of genetic and linguistic diversity in Northern Island Melanesia. Here we utilize that diversity to examine two models of genetic and linguistic coevolution. The first...
- 2From: PLoS Genetics. (Vol. 4, Issue 10) Peer-ReviewedThe Hippo pathway negatively regulates the cell number in epithelial tissue. Upon its inactivation, an excess of cells is produced. These additional cells are generated from an increased rate of cell division, followed...
- 3From: PLoS Genetics. (Vol. 4, Issue 10) Peer-ReviewedGenetical genomics aims at identifying quantitative trait loci (QTLs) for molecular traits such as gene expression or protein levels (eQTL and pQTL, respectively). One of the central concepts in genetical genomics is...
- 4From: PLoS Genetics. (Vol. 4, Issue 10) Peer-ReviewedSkeletal muscle morphogenesis transforms short muscle precursor cells into long, multinucleate myotubes that anchor to tendons via the myotendinous junction (MTJ). In vertebrates, a great deal is known about muscle...
- 5From: PLoS Genetics. (Vol. 4, Issue 10) Peer-ReviewedCrossover recombination and the formation of chiasmata normally ensure the proper segregation of homologous chromosomes during the first meiotic division. zhp-3, the Coenorhabditis elegans ortholog of the budding yeast...
- 6From: PLoS Genetics. (Vol. 4, Issue 10) Peer-ReviewedFor most organisms, food is only intermittently available; therefore, molecular mechanisms that couple sensation of nutrient availability to growth and development are critical for survival. These mechanisms, however,...
- 7From: PLoS Genetics. (Vol. 4, Issue 10) Peer-ReviewedThe Coenorhabditis elegans pharynx (or foregut) functions as a pump that draws in food (bacteria) from the environment. While the "organ identity factor" PHA-4 is critical for formation of the C. elegans pharynx as a...
- 8From: PLoS Genetics. (Vol. 4, Issue 10) Peer-ReviewedIn bacterial, yeast, and human cells, stress-induced mutation mechanisms are induced in growth-limiting environments and produce non-adaptive and adaptive mutations. These mechanisms may accelerate evolution...
- 9From: PLoS Genetics. (Vol. 4, Issue 10) Peer-ReviewedComplex genetic networks consist of structural modules that determine the levels and timing of a cellular response. While the functional properties of the regulatory architectures that make up these modules have been...
- 10From: PLoS Genetics. (Vol. 4, Issue 10) Peer-ReviewedRefractive error is a highly heritable quantitative trait responsible for considerable morbidity. Following an initial genomewide linkage study using microsatellite markers, we confirmed evidence for linkage to...
- 11From: PLoS Genetics. (Vol. 4, Issue 10) Peer-ReviewedThe genetic basis of the development and variation of adult form of vertebrates is not well understood. To address this problem, we performed a mutant screen to identify genes essential for the formation of adult...
- 12From: PLoS Genetics. (Vol. 4, Issue 10) Peer-ReviewedCopy number polymorphism (CNP) is ubiquitous in eukaryotic genomes, but the degree to which this reflects the action of positive selection is poorly understood. The first gene in the Plasmodium folate biosynthesis...
- 13From: PLoS Genetics. (Vol. 4, Issue 10) Peer-ReviewedPolycomb and trithorax group proteins regulate cellular pluripotency and differentiation by maintaining hereditable states of transcription. Many Polycomb and trithorax group proteins have been implicated in the...
- 14From: PLoS Genetics. (Vol. 4, Issue 10) Peer-ReviewedEthosuximide is a medication used to treat seizure disorders in humans, and we previously demonstrated that ethosuximide can delay age-related changes and extend the lifespan of the nematode Coenorhabditis elegans....
- 15From: PLoS Genetics. (Vol. 4, Issue 10) Peer-ReviewedExonization of Alu elements is a major mechanism for birth of new exons in primate genomes. Prior analyses of expressed sequence tags show that almost all Alu-derived exons are alternatively spliced, and the vast...
- 16From: PLoS Genetics. (Vol. 4, Issue 10) Peer-ReviewedProgressive hearing loss is common in the human population, but we have few clues to the molecular basis. Mouse mutants with progressive hearing loss offer valuable insights, and ENU (N-ethyl-N-nitrosourea) mutagenesis...
- 17From: PLoS Genetics. (Vol. 4, Issue 10) Peer-ReviewedThe recessive lethal mutation flotte lotte (flo) disrupts development of the zebrafish digestive system and other tissues. We show that flo encodes the ortholog of Mel-28/Elys, a highly conserved gene that has been...
- 18From: PLoS Genetics. (Vol. 4, Issue 10) Peer-ReviewedAt least six histone H1 variants exist in somatic mammalian cells that bind to the linker DNA and stabilize the nucleosome particle contributing to higher order chromatin compaction. In addition, H1 seems to be actively...
- 19From: PLoS Genetics. (Vol. 4, Issue 10) Peer-ReviewedInteractions between an organism and its environment can significantly influence phenotypic evolution. A first step toward understanding this process is to characterize phenotypic diversity within and between...
- 20From: PLoS Genetics. (Vol. 4, Issue 10) Peer-ReviewedThere is considerable interest from the wider scientific community in the heritability of epigenetic states across generations, and this has arisen as a result of a series of studies in mice [1, 2], flies [3], plants...