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- Search Terms:ISSN: 15537390AndISSN: 15537404AndVolume Number: 4AndIssue Number: 1AndStart Page: e1AndDate: 2008 Revise Search
- 1From: PLoS Genetics. (Vol. 4, Issue 1) Peer-ReviewedHaplotype maps (HapMaps) reveal underlying sequence variation and facilitate the study of recombination and genetic diversity. In general, HapMaps are produced by analysis of Single-Nucleotide Polymorphism (SNP)...
- 2From: PLoS Genetics. (Vol. 4, Issue 1) Peer-ReviewedIn most cell types, mitosis and cytokinesis are tightly coupled such that cytokinesis occurs only once per cell cycle. The fission yeast Schizosaccharomyces pombe divides using an actomyosin-based contractile ring and...
- 3From: PLoS Genetics. (Vol. 4, Issue 1) Peer-ReviewedA fundamental issue in molecular evolution is how to identify the evolutionary forces that determine the fate of duplicated genes. The dosage balance hypothesis has been invoked to explain gene duplication patterns at...
- 4From: PLoS Genetics. (Vol. 4, Issue 1) Peer-ReviewedFor several decades, only a limited number of noncoding RNAs, such as ribosomal and transfer RNA, have been studied in any depth. In recent years, additional species of noncoding RNAs have increasingly been discovered....
- 5From: PLoS Genetics. (Vol. 4, Issue 1) Peer-ReviewedEuropean population genetic substructure was examined in a diverse set of >1,000 individuals of European descent, each genotyped with >300 K SNPs. Both STRUCTURE and principal component analyses (PCA) showed the largest...
- 6From: PLoS Genetics. (Vol. 4, Issue 1) Peer-ReviewedMutations in optic atrophy 1 (OPA1), a nuclear gene encoding a mitochondrial protein, is the most common cause for autosomal dominant optic atrophy (DOA). The condition is characterized by gradual loss of vision, color...
- 7From: PLoS Genetics. (Vol. 4, Issue 1) Peer-ReviewedCircadian clocks organize the precise timing of cellular and behavioral events. In Drosophila, circadian clocks consist of negative feedback loops in which the clock component PERIOD (PER) represses its own...
- 8From: PLoS Genetics. (Vol. 4, Issue 1) Peer-ReviewedX chromosome inactivation in female mammals results in dosage compensation of X-linked gene products between the sexes. In humans there is evidence that a substantial proportion of genes escape from silencing. We have...
- 9From: PLoS Genetics. (Vol. 4, Issue 1) Peer-ReviewedEuropean Americans are often treated as a homogeneous group, but in fact form a structured population due to historical immigration of diverse source populations. Discerning the ancestry of European Americans genotyped...
- 10From: PLoS Genetics. (Vol. 4, Issue 1) Peer-ReviewedConstitutive heterochromatin is enriched in repetitive sequences and histone H3-methylated-at-lysine 9. Both components contribute to heterochromatin's ability to silence euchromatic genes. However, heterochromatin also...
- 11From: PLoS Genetics. (Vol. 4, Issue 1) Peer-ReviewedCalorie restriction (CR), the only non-genetic intervention known to slow aging and extend life span in organisms ranging from yeast to mice, has been linked to the down-regulation of Tor, Akt, and Ras signaling. In...
- 12From: PLoS Genetics. (Vol. 4, Issue 1) Peer-ReviewedHuman genetic diversity in the Pacific has not been adequately sampled, particularly in Melanesia. As a result, population relationships there have been open to debate. A genome scan of autosomal markers (687...
- 13From: PLoS Genetics. (Vol. 4, Issue 1) Peer-ReviewedWhile pleiotropic adaptive mutations are thought to be central for evolution, little is known on the downstream molecular effects allowing adaptation to complex ecologically relevant environments. Here we show that...
- 14From: PLoS Genetics. (Vol. 4, Issue 1) Peer-ReviewedIntense investigation has identified an elaborate protein network controlling epithelial polarity. Although precise subcellular targeting of apical and basolateral determinants is required for epithelial architecture,...
- 15From: PLoS Genetics. (Vol. 4, Issue 1) Peer-ReviewedRecently, whole genome association (WGA) studies have accelerated progress in the search for genetic variations underlying the inheritance of complex genetic diseases. Although population differences in allele...
- 16From: PLoS Genetics. (Vol. 4, Issue 1) Peer-ReviewedPrevious studies of repetitive elements (REs) have implicated a mechanistic role in generating new chimerical genes. Such examples are consistent with the classic model for exon shuffling, which relies on non-homologous...
- 17From: PLoS Genetics. (Vol. 4, Issue 1) Peer-ReviewedIntrinsic immunity relies on specific recognition of viral epitopes to mount a cell-autonomous defense against viral infections. Viral recognition determinants in intrinsic immunity genes are expected to evolve rapidly...
- 18From: PLoS Genetics. (Vol. 4, Issue 1) Peer-ReviewedTelomerase serves a critical role in stem cell function and tissue homeostasis. This role depends on its ability to synthesize telomere repeats in a manner dependent on the reverse transcriptase (RT) function of its...