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- 1From: Nature Reviews Molecular Cell Biology. (Vol. 4, Issue 1) Peer-Reviewed* http://scop.mrc-lmb.cam.ac.uk/scop/ In Russian, the word scop (ckon) can mean a 'pile' or 'accumulation'. In English, however, it stands for something completely different--the 'structural classification of...
- 2From: Nature Reviews Molecular Cell Biology. (Vol. 4, Issue 1) Peer-ReviewedThe conversion of stationary epithelial cells into migratory, invasive cells is important for normal embryonic development and tumour metastasis. Border-cell migration in the ovary of Drosophila melanogaster has emerged...
- 3From: Nature Reviews Molecular Cell Biology. (Vol. 4, Issue 1) Peer-ReviewedCollins, N. et al. Nature Genet. 32, 627-632 (2002) The mechanism that enables the DNA replication machinery to penetrate heterochromatin is poorly understood. However, Collins et al. now provide evidence that an...
- 4From: Nature Reviews Molecular Cell Biology. (Vol. 4, Issue 1) Peer-ReviewedNature Rev. Mol. Cell Bio. 3, 906-918 (2002) The address list shown was incorrect and should have read: Jin Zhang *, Robert E. Campbell *, Alice Y. Ting * ([double dagger]) and Roger Y. Tsien * ([section]) *...
- 5From: Nature Reviews Molecular Cell Biology. (Vol. 4, Issue 1) Peer-ReviewedManning, G. et al. Science 298, 1912-1918 (2002) Most protein kinases belong to a single superfamily, the members of which contain a eukaryotic protein kinase (ePK) catalytic domain. Manning etal. have now catalogued...
- 6From: Nature Reviews Molecular Cell Biology. (Vol. 4, Issue 1) Peer-ReviewedSynapses are sites where nerve impulses are transmitted from the axon of one neuron to the dendrite of an adjacent neuron, and the transformation of an initial axon-dendrite contact into a functional synapse requires...
- 7From: Nature Reviews Molecular Cell Biology. (Vol. 4, Issue 1) Peer-ReviewedIn 1902, Emilio Veratti made the most accurate description, by light microscopy, of a reticular structure in the sarcoplasm. However, this structure was almost lost to man's knowledge for more than 50 years and was...
- 8From: Nature Reviews Molecular Cell Biology. (Vol. 4, Issue 1) Peer-ReviewedMost mitochondrial proteins are synthesized in the cytosol, so they reach their final destination courtesy of the TOM complex (translocase of the outer mitochondrial membrane) and one of two TIM complexes (translocases...
- 9From: Nature Reviews Molecular Cell Biology. (Vol. 4, Issue 1) Peer-ReviewedLosada, A. et al. Genes Dev. 16, 3004-3016 (2002) Cohesin and condensin are protein complexes that mediate sister-chromatid cohesion and condensation, respectively, in preparation for sister-chromatid separation. In...
- 10From: Nature Reviews Molecular Cell Biology. (Vol. 4, Issue 1) Peer-ReviewedThe Wiskott-Aldrich syndrome protein (WASP) and its homologue N-WASP promote actin polymerization in response to upstream signals, and their importance is highlighted by the Wiskott-Aldrich syndrome (WAS)--an immune...
- 11From: Nature Reviews Molecular Cell Biology. (Vol. 4, Issue 1) Peer-ReviewedSteroid hormones modulate many physiological processes. The effects of steroids that are mediated by the modulation of gene expression are known to occur with a time lag of hours or even days. Research that has been...
- 12From: Nature Reviews Molecular Cell Biology. (Vol. 4, Issue 1) Peer-ReviewedThe activation of apoptotic cascades triggers a series of events, one of which is the condensation and fragmentation of chromosomal DNA. In mammals, at least three proteins have been implicated in this...
- 13From: Nature Reviews Molecular Cell Biology. (Vol. 4, Issue 1) Peer-ReviewedThis month's winning image was submitted by Keisuke Obara (University of Tokyo (ss17196@mail.ecc.u-tokyo.ac.jp)). It shows plant (Zinnia elegans) vessel elements transdifferentiated from mesophyll cells in vitro....
- 14From: Nature Reviews Molecular Cell Biology. (Vol. 4, Issue 1) Peer-ReviewedProteomics is now considered to be one of the most important 'post-genome' approaches to help us understand gene function. In fact, several genomics companies have launched large-scale proteomics projects, and have...
- 15From: Nature Reviews Molecular Cell Biology. (Vol. 4, Issue 1) Peer-ReviewedSo far, the only effective way for you to live longer has been to restrict your calorific intake. But a report by Holzenberger and colleagues in Nature might offer another potential way--knocking out the insulin-like...
- 16From: Nature Reviews Molecular Cell Biology. (Vol. 4, Issue 1) Peer-ReviewedArchitects of any structure know the importance of defining the limits and orientation of a building. The top and bottom must be established and maintained, with interactions between all walls, ceilings and floors...
- 17From: Nature Reviews Molecular Cell Biology. (Vol. 4, Issue 1) Peer-ReviewedThe eukaryotic genome is divided into well-defined DNA regions that are programmed to replicate at different times during S phase. Active genes are generally associated with early replication, whereas inactive genes...
- 18From: Nature Reviews Molecular Cell Biology. (Vol. 4, Issue 1) Peer-ReviewedMucosal surfaces--such as the lining of the gut or the reproductive tract--are the main point of entry for viruses into the body. As such, almost all viruses interact with epithelial cells, and make use of the normal...
- 19From: Nature Reviews Molecular Cell Biology. (Vol. 4, Issue 1) Peer-ReviewedDifferent types of stem cells share certain properties, such as plasticity and self-renewal, which indicates that they might have common cellular machineries. Tsai and McKay now report in Genes & Development a nucleolar...
- 20From: Nature Reviews Molecular Cell Biology. (Vol. 4, Issue 1) Peer-ReviewedIn eukaryotes, ATP-dependent chromatin-remodelling complexes have an important function in regulating promoter accessibility for transcription. Complexes such as SWI2-SNF2 'remodel' the nucleosome architecture using...