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- 1From: The Pharmacogenomics Journal. (Vol. 4, Issue 1) Peer-ReviewedAuthor(s): T E Klein [1]; R B Altman [1] The Pharmacogenetics and Pharmacogenomics Knowledge Base (PharmGKB, http://www.pharmgkb.org) is a public repository of genotype and phenotype information relevant to...
- 2From: The Pharmacogenomics Journal. (Vol. 4, Issue 1) Peer-ReviewedAuthor(s): T Fukuda [1]; S Onishi [1]; S Fukuen [1]; Y Ikenaga [1]; M Ohno [1]; K Hoshino [1]; K Matsumoto [1]; A Maihara [2]; K Momiyama [2]; T Ito [3]; Y Fujio [1]; J Azuma [1] INTRODUCTION Cytochrome...
- 3From: The Pharmacogenomics Journal. (Vol. 4, Issue 1) Peer-ReviewedAuthor(s): M Wadelius [1]; K Sörlin [1]; O Wallerman [2]; J Karlsson [1]; Q-Y Yue [3]; P K E Magnusson [2]; C Wadelius [2]; H Melhus [1] INTRODUCTION Nearly 1% of the Swedish population is treated with the oral...
- 4From: The Pharmacogenomics Journal. (Vol. 4, Issue 1) Peer-ReviewedAuthor(s): L Frazier [1]; S T Turner [2]; G L Schwartz [2]; A B Chapman [3]; E Boerwinkle [4] INTRODUCTION Hypertension (HTN), a major risk factor for cardiovascular disease, stroke, and renal disease, affects...
- 5From: The Pharmacogenomics Journal. (Vol. 4, Issue 1) Peer-ReviewedAn overview of the comparative toxicogenomics database Toxicogenomics is a relatively new field of study oriented toward the investigation of the interplay between environmental factors and specific genes and genetic...
- 6From: The Pharmacogenomics Journal. (Vol. 4, Issue 1) Peer-ReviewedAuthor(s): C Weijer [1]; P B Miller [1] INTRODUCTION While much has been written on the potential for pharmacogenetic and pharmacogenomic research to improve our understanding and treatment of disease, considerably...
- 7From: The Pharmacogenomics Journal. (Vol. 4, Issue 1) Peer-ReviewedAuthor(s): H-J Lee [1]; J-H Cha [1]; B-J Ham [1]; C-S Han [1]; Y-K Kim [1]; S-H Lee [2]; S-H Ryu [3]; R-H Kang [1]; M-J Choi [1]; M-S Lee [1] INTRODUCTION Hundreds of cell-surface receptors for neurotransmitters and...
- 8From: The Pharmacogenomics Journal. (Vol. 4, Issue 1) Peer-ReviewedThe central role of 5,10-methylenetetrahydrofolate reductase (MTHFR) and methylenetetrahydrofolate dehydrogenase (MTHFD1) in folate metabolism renders polymorphisms in genes encoding these enzymes potential modulators...
- 9From: The Pharmacogenomics Journal. (Vol. 4, Issue 1) Peer-ReviewedTranilast (N-(3'4'-demethoxycinnamoyl)-anthranilic acid (N-5)) is an investigational drug for the prevention of restenosis following percutaneous transluminal coronary revascularization. An increase in bilirubin levels...
- 10From: The Pharmacogenomics Journal. (Vol. 4, Issue 1) Peer-ReviewedAuthor(s): C J Mattingly [1]; G T Colby [1]; M C Rosenstein [1]; J N Forrest, Jr [2]; J L Boyer [2] The etiology of many chronic diseases involves interactions between environmental factors and genes that regulate...
- 11From: The Pharmacogenomics Journal. (Vol. 4, Issue 1) Peer-ReviewedThe major metabolite from the use of furazolidone (FZD) in mammals, birds and fish is 2,3-dihydro-3-cyanomethyl-2-hydroxy-5-nitro-1alpha, 2-di(2-oxo-oxazolidin-3-yl)iminomethyl-furo[2,3-[beta]]furan, also called...
- 12From: The Pharmacogenomics Journal. (Vol. 4, Issue 1) Peer-ReviewedA total of 10 SULT genes are presently known to be expressed in human tissues. We performed a comprehensive genome-wide search for novel SULT genes using two different but complementary approaches, and developed a novel...
- 13From: The Pharmacogenomics Journal. (Vol. 4, Issue 1) Peer-ReviewedAuthor(s): M Soyka [1] There is overwhelming evidence for genes to play a substantial role in the development of alcoholism. Of the population variance for alcoholism, 50-60% vulnerability may be explained by...