Showing Results for
- Academic Journals (82)
Search Results
- 82
Academic Journals
- 82
- Search Terms:
- 1From: BMC Medical Genomics. (Vol. 4) Peer-ReviewedBackground We consider the problem of designing a study to develop a predictive classifier from high dimensional data. A common study design is to split the sample into a training set and an independent test set,...
- 2From: BMC Medical Genomics. (Vol. 4) Peer-ReviewedBackground Recent genome-wide association (GWA) analyses have identified common single nucleotide polymorphisms (SNPs) that are associated with obesity. However, the reported genetic variation in obesity explains...
- 3From: BMC Medical Genomics. (Vol. 4) Peer-ReviewedBackground Molecular classification of tumors can be achieved by global gene expression profiling. Most machine learning classification algorithms furnish global error rates for the entire population. A few...
- 4From: BMC Medical Genomics. (Vol. 4) Peer-ReviewedBackground Inflammation plays an important role in cardiac repair after myocardial infarction (MI). Nevertheless, the systems-level characterization of inflammation proteins in MI remains incomplete. There is a need...
- 5From: BMC Medical Genomics. (Vol. 4) Peer-ReviewedBackground An understanding of the relation of commensal microbiota to health is essential in preventing disease. Here we studied the oral microbial composition of children (N = 74, aged 3 - 18 years) in natural...
- 6From: BMC Medical Genomics. (Vol. 4) Peer-ReviewedBackground Gene fusions arising from chromosomal translocations have been implicated in cancer. However, the role of gene fusions in BRCA1-related breast cancers is not well understood. Mutations in BRCA1 are...
- 7From: BMC Medical Genomics. (Vol. 4) Peer-ReviewedBackground Copy number variants (CNV) are a potentially important component of the genetic contribution to risk of common complex diseases. Analysis of the association between CNVs and disease requires that...
- 8From: BMC Medical Genomics. (Vol. 4) Peer-ReviewedBackground Sporadic amyotrophic lateral sclerosis (sALS) is a motor neuron disease with poorly understood etiology. Results of gene expression profiling studies of whole blood from ALS patients have not been...
- 9From: BMC Medical Genomics. (Vol. 4) Peer-ReviewedBackground Copy number alterations (CNA) play a key role in cancer development and progression. Since more than one CNA can be detected in most tumors, frequently co-occurring genetic CNA may point to cooperating...
- 10From: BMC Medical Genomics. (Vol. 4) Peer-ReviewedBackground In cancer prognosis studies with gene expression measurements, an important goal is to construct gene signatures with predictive power. In this study, we describe the coordination among genes using the...
- 11From: BMC Medical Genomics. (Vol. 4) Peer-ReviewedBackground Readthrough fusions across adjacent genes in the genome, or transcription-induced chimeras (TICs), have been estimated using expressed sequence tag (EST) libraries to involve 4-6% of all genes. Deep...
- 12From: BMC Medical Genomics. (Vol. 4) Peer-ReviewedBackground Glioblastoma multiforme (GBM) tends to occur between the ages of 45 and 70. This relatively early onset and its poor prognosis make the impact of GBM on public health far greater than would be suggested by...
- 13From: BMC Medical Genomics. (Vol. 4) Peer-ReviewedBackground Facioscapulohumeral muscular dystrophy (FSHD) is a dominant disease linked to contraction of an array of tandem 3.3-kb repeats (D4Z4) at 4q35. Within each repeat unit is a gene, DUX4, that can encode a...
- 14From: BMC Medical Genomics. (Vol. 4) Peer-ReviewedBackground Resistance to chemotherapy severely limits the effectiveness of chemotherapy drugs in treating cancer. Still, the mechanisms and critical pathways that contribute to chemotherapy resistance are relatively...
- 15From: BMC Medical Genomics. (Vol. 4) Peer-ReviewedBackground The ability to share human biological samples, associated data and results across disease-specific and population-based human research biobanks is becoming increasingly important for research into disease...
- 16From: BMC Medical Genomics. (Vol. 4) Peer-ReviewedBackground Mesenchymal stem cell (MSC) found in bone marrow (BM-MSCs) and the Wharton's jelly matrix of human umbilical cord (WJ-MSCs) are able to transdifferentiate into neuronal lineage cells both in vitro and in...
- 17From: BMC Medical Genomics. (Vol. 4) Peer-ReviewedBackground Conventional high-grade osteosarcoma is a primary malignant bone tumor, which is most prevalent in adolescence. Survival rates of osteosarcoma patients have not improved significantly in the last 25 years....
- 18From: BMC Medical Genomics. (Vol. 4) Peer-ReviewedBackground Tetralogy of Fallot (TOF) is the most commonly observed conotruncal congenital heart defect. Treatment of these patients has evolved dramatically in the last few decades, yet a genetic explanation is...
- 19From: BMC Medical Genomics. (Vol. 4) Peer-ReviewedBackground Transgenic mouse tumor models have the advantage of facilitating controlled in vivo oncogenic perturbations in a common genetic background. This provides an idealized context for generating...
- 20From: BMC Medical Genomics. (Vol. 4) Peer-ReviewedBackground We performed a genome-wide scan of 27,578 CpG loci covering 14,475 genes to identify differentially methylated loci (DML) in colorectal carcinoma (CRC). Methods We used Illumina's Infinium...