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- 1From: Nature Genetics. (Vol. 39, Issue 9) Peer-ReviewedSurveys of protein-coding sequences for evidence of positive selection in humans or chimpanzees have flagged only a few genes known to function in neural or nutritional processes (1-5), despite pronounced differences...
- 2From: Nature Genetics. (Vol. 39, Issue 9) Peer-ReviewedThe genome of the laboratory mouse is thought to be a mosaic of regions with distinct subspecific origins. We have developed a high-resolution map of the origin of the laboratory mouse by generating 25,400 phylogenetic...
- 3From: Nature Genetics. (Vol. 39, Issue 9) Peer-ReviewedWe report germline loss-of-function mutations in SPRED1 in a newly identified autosomal dominant human disorder. SPRED1 is a member of the SPROUTY/SPRED family (1) of proteins that act as negative regulators of RAS-RAF...
- 4From: Nature Genetics. (Vol. 39, Issue 9) Peer-ReviewedFusion between mitochondria is important in determining mitochondrial morphology and in protecting mitochondrial function by allowing content mixing. Proteins encoded by the MFN1, MFN2 and OPA1 genes are required for...
- 5From: Nature Genetics. (Vol. 39, Issue 9) Peer-ReviewedNonsense-mediated mRNA decay (NMD) is of universal biological significance (1-3). It has emerged as an important global RNA, DNA and translation regulatory pathway [4]. By systematically sequencing 737 genes (annotated...
- 6From: Nature Genetics. (Vol. 39, Issue 9) Peer-ReviewedA complete picture of the architecture of human genetic disease will require an unbiased accounting of allele frequencies of common variants across multiple populations. At least some of the efforts thus far have been...
- 7From: Nature Genetics. (Vol. 39, Issue 9) Peer-ReviewedThe Genetic Association Information Network (GAIN) is a public-private partnership established to investigate the genetic basis of common diseases through a series of collaborative genome-wide association studies. GAIN...
- 8From: Nature Genetics. (Vol. 39, Issue 9) Peer-ReviewedAnne McLaren died in a car accident along with her former husband and lifelong friend Donald Michie while traveling from Cambridge to London on 7 July 2007. While she made major contributions to studies of mouse genetics...
- 9From: Nature Genetics. (Vol. 39, Issue 9) Peer-ReviewedWe have identified a recurrent de novo pericentromeric deletion in 16p11.2-p12.2 in four individuals with developmental disabilities by microarray-based comparative genomic hybridization analysis. The identification of...
- 10From: Nature Genetics. (Vol. 39, Issue 9) Peer-ReviewedCrop yields are significantly reduced by aluminum toxicity on highly acidic soils, which comprise up to 50% of the world's arable land (1-3). Candidate aluminum tolerance proteins include organic acid efflux...
- 11From: Nature Genetics. (Vol. 39, Issue 9) Peer-ReviewedTwo reports present detailed analyses of the haplotype structure of widely used laboratory mice based on resequencing data from 15 inbred strains. The studies provide the deepest view thus far of the patterns of genetic...
- 12From: Nature Genetics. (Vol. 39, Issue 9) Peer-ReviewedThis month we feature the C. elegans ced-3 mutant to highlight its role in proving that apoptotic cell death is under genetic control. This mutant was identified by Hilary Ellis and H. Robert Horvitz in 1986 in a screen...
- 13From: Nature Genetics. (Vol. 39, Issue 9) Peer-ReviewedCentronuclear myopathies are characterized by muscle weakness and abnormal centralization of nuclei in muscle fibers not secondary to regeneration. The severe neonatal X-linked form (myotubular myopathy) is due to...
- 14From: Nature Genetics. (Vol. 39, Issue 9) Peer-Reviewed"We fear the abruptness with which a lead in science and technology can be lost-and the difficulty of recovering a lead once lost, if indeed it can be regained at all." --National Academy of Sciences Report, Rising...
- 15From: Nature Genetics. (Vol. 39, Issue 9) Peer-ReviewedTREX1 acts in concert with the SET complex in granzyme A-mediated apoptosis, and mutations in TREX1 cause Aicardi-Goutieres syndrome and familial chilblain lupus. Here, we report monoallelic frameshift or missense...
- 16From: Nature Genetics. (Vol. 39, Issue 9) Peer-ReviewedThe amplification of genomic regions is one of the hallmarks of cancer, although the mechanisms that underlie these events are not entirely understood. Graham Bignell and colleagues report the use of BAC-based end...
- 17From: Nature Genetics. (Vol. 39, Issue 9) Peer-ReviewedInteractions of killer cell immunoglobulin-like receptors (KIRs) with major histocompatibility complex (MHC) class I ligands diversify natural killer cell responses to infection. By analyzing sequence variation in...
- 18From: Nature Genetics. (Vol. 39, Issue 9) Peer-ReviewedWest Nile virus (WNV), first recognized in North America in 1999, has been responsible for the largest arboviral epiornitic and epidemic of human encephalitis in recorded history. Despite the well-described...
- 19From: Nature Genetics. (Vol. 39, Issue 9) Peer-ReviewedThe cover of this issue is the genetic code visualized as a six-set Edwards-Venn diagram with 26 = 64 areas-one for each codondesigned by Anthony W. P. Edwards (University of Cambridge), who explains the diagram as...
- 20From: Nature Genetics. (Vol. 39, Issue 9) Peer-ReviewedThe report of a haplotype map for the selfing plant Arabidopsis thaliana has uncovered numerous major-effect polymorphisms and rapid linkage disequilibrium decay. This work lays the foundation for genome-wide association...