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- 1From: Oncogene. (Vol. 33, Issue 12) Peer-ReviewedThe promyelocytic leukemia (PML) protein, initially discovered as a part of the PML/retinoic acid receptor alpha fusion protein, has been found to be a critical player in oncogenesis and tumor progression. Multiple...
- 2From: Oncogene. (Vol. 33, Issue 12) Peer-ReviewedThe accumulation of genetic and epigenetic alterations mediates colorectal cancer (CRC) formation by deregulating key signaling pathways in cancer cells. In CRC, one of the most commonly inactivated signaling pathways...
- 3From: Oncogene. (Vol. 33, Issue 12) Peer-ReviewedMutant p53 proteins are expressed at high frequency in human tumors and are associated with poor clinical prognosis and resistance to chemotherapeutic treatments. Here we show that mutant p53 proteins downregulate...
- 4From: Oncogene. (Vol. 33, Issue 12) Peer-ReviewedMicroRNAs (miRNAs) are increasingly implicated in regulating tumor malignance through their capacity to coordinately repress expression of tumor-related genes. Here, we show that overexpression of miR-194 in lung cancer...
- 5From: Oncogene. (Vol. 33, Issue 12) Peer-ReviewedThe mammalian target of rapamycin (mTOR) regulates cell growth by integrating nutrient and growth factor signaling and is strongly implicated in cancer. But mTOR is not an oncogene, and which tumors will be resistant or...
- 6From: Oncogene. (Vol. 33, Issue 12) Peer-ReviewedGrowth of breast cancers is often dependent on ovarian steroid hormones making the tumors responsive to antagonists of hormone receptors. However, eventually the tumors become hormone independent, raising the need to...
- 7From: Oncogene. (Vol. 33, Issue 12) Peer-ReviewedCancer stem cell (CSC) biology and the epithelial-to-mesenchymal transition (EMT) are thought to be mechanistically linked and may be key components of cancer development and progression. However, stimuli that induce...
- 8From: Oncogene. (Vol. 33, Issue 12) Peer-ReviewedHomologous recombination (HR), a mechanism to accurately repair DNA in normal cells, is deregulated in cancer. Elevated/deregulated HR is implicated in genomic instability and telomere maintenance, which are critical...
- 9From: Oncogene. (Vol. 33, Issue 12) Peer-ReviewedHistone deacetylase inhibitors (HDACis) are a promising class of anticancer epigenetic drugs, however, molecular factors influencing the responses of individual tumors to HDACi therapies remain obscure. Here, we sought...
- 10From: Oncogene. (Vol. 33, Issue 12) Peer-ReviewedP63, a p53 family member, is expressed as TA and [DELTA]N isoforms. Interestingly, both TAp63 and [DELTA]Np63 are transcription factors, and regulate both common and distinct sets of target genes. p63 is required for...
- 11From: Oncogene. (Vol. 33, Issue 12) Peer-ReviewedPDZ domains represent one group of the major structural units that mediate protein interactions in intercellular contact, signal transduction and assembly of biological machineries. Tax-interacting protein (TIP)-1...
- 12From: Oncogene. (Vol. 33, Issue 12) Peer-ReviewedThe v-erbA oncogene transforms chicken erythrocytic progenitors (T2EC) by blocking their differentiation and freezing them in a state of self-renewal. Transcriptomes of T2EC, expressing either v-erbA or a...
- 13From: Oncogene. (Vol. 33, Issue 12) Peer-ReviewedP53 inactivation by p53 mutation and E6 oncoprotein has a crucial role in human carcinogenesis. DDX3 has been shown to be a target of p53. In this study, we hypothesized that DDX3 loss by p53 inactivation may promote...