Showing Results for
- Academic Journals (14)
Search Results
- 14
Academic Journals
- 14
- Search Terms:
- 1From: Oncogene. (Vol. 33, Issue 11) Peer-ReviewedThe androgen receptor (AR) stimulates and represses gene expression to promote the initiation and progression of prostate cancer. Here, we report that androgen represses the miR-99a/let7c/125b-2 cluster through AR and...
- 2From: Oncogene. (Vol. 33, Issue 11) Peer-ReviewedThe MST/YAP (mammalian Ste20-like kinase/Yes-associated protein 2) pathway plays an important role in hepatocellular carcinoma (HCC). Although post-translational modification--especially MST/Lats (large tumor...
- 3From: Oncogene. (Vol. 33, Issue 11) Peer-ReviewedIn addition to its direct effects on tumor cells, chemotherapy can rapidly activate various host processes that contribute to therapy resistance and tumor regrowth. The host response to chemotherapy consists of changes...
- 4From: Oncogene. (Vol. 33, Issue 11) Peer-ReviewedRUNX3 is silenced by histone modification and hypoxia-inducible factor (HIF)- 1[alpha] is stabilized under hypoxia, but little is known of cross-talk between RUNX3 and (HIF)-1[alpha] under hypoxia. In the present study,...
- 5From: Oncogene. (Vol. 33, Issue 11) Peer-ReviewedMost chemotherapeutical drugs kill cancer cells chiefly by inducing DNA damage, which unfortunately also causes undesirable injuries to normal tissues, mainly due to p53 activation. We report a novel strategy of normal...
- 6From: Oncogene. (Vol. 33, Issue 11) Peer-ReviewedHyperactive ribosomal biogenesis is widely observed in cancer, which has been partly attributed to the increased rDNA transcription by Pol I in cancer. However, whether small nucleolar RNAs (snoRNAs), a class of...
- 7From: Oncogene. (Vol. 33, Issue 11) Peer-ReviewedWithin the family of protein kinase C (PKC) molecules, the novel isoform PRKCE (PKC[epsilon]) acts as a bona fide oncogene in in vitro and in vivo models of tumorigenesis. Previous studies have reported expression of...
- 8From: Oncogene. (Vol. 33, Issue 11) Peer-ReviewedMultiple growth pathways lead to enhanced proliferation in malignant cells. However, how the core machinery of DNA replication is regulated by growth signaling remains largely unclear. The sliding clamp proliferating...
- 9From: Oncogene. (Vol. 33, Issue 11) Peer-ReviewedTartrate-resistant acid phosphatase 5 (ACP5), which is essential for bone resorption and osteoclast differentiation, promotes cell motility through the modulation of focal adhesion kinase phosphorylation. However,...
- 10From: Oncogene. (Vol. 33, Issue 11) Peer-ReviewedSerine/arginine-rich splicing factor 3 (SRSF3) likely has wide-ranging roles in gene expression and facilitation of tumor cell growth. SRSF3 knockdown induced G1 arrest and apoptosis in colon cancer cells (HCT116) in...
- 11From: Oncogene. (Vol. 33, Issue 11) Peer-ReviewedEstrogen receptor-alpha (ER[alpha]) is an important biomarker used to classify and direct therapy decisions in breast cancer (BC). Both ER[alpha] protein and its transcript, ESR1, are used to predict response to...
- 12From: Oncogene. (Vol. 33, Issue 11) Peer-ReviewedThe taxanes are effective microtubule-stabilizing chemotherapy drugs used in the treatment of various solid tumors. However, the emergence of drug resistance hampers their clinical efficacy. The molecular basis of...
- 13From: Oncogene. (Vol. 33, Issue 11) Peer-ReviewedThe mRNA cap-binding protein eIF4E (eukaryotic translation initiation factor 4E) permits ribosome recruitment to capped mRNAs, and its phosphorylated form has an important role in cell transformation. The oncogenic...
- 14From: Oncogene. (Vol. 33, Issue 11) Peer-ReviewedEGFR overexpression and chromosome 3p deletion are two frequent events in head and neck cancers. We previously mapped the smallest region of recurrent copy-number loss at 3p12.2-p14.1. LRIG1, a negative regulator of...