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- 1From: Oncogene. (Vol. 32, Issue 33) Peer-ReviewedCancer stem cells are believed to be responsible for tumor initiation and development. Much current research on human brain tumors is focused on the stem-like properties of glioblastoma stem cells (GSCs). However,...
- 2From: Oncogene. (Vol. 32, Issue 33) Peer-ReviewedMalignant cell transformation commonly results in the deregulation of thousands of cellular genes, an observation that suggests a complex biological process and an inherently challenging scenario for the development of...
- 3From: Oncogene. (Vol. 32, Issue 33) Peer-ReviewedHypothyroidism has been associated with significantly elevated risk for hepatocellular carcinoma (HCC), although the precise underlying mechanisms remain unknown at present. Thyroid hormone ([T.sub.3]) and its receptor...
- 4From: Oncogene. (Vol. 32, Issue 33) Peer-ReviewedThe mechanisms controlling expression of the putative oncogene Anterior gradient 2 (AGR2) in pancreatic ductal adenocarcinoma (PDAC) are not well understood. We now show that AGR2 is a transforming growth factor-[beta]...
- 5From: Oncogene. (Vol. 32, Issue 33) Peer-ReviewedThe epidermal growth factor receptor (EGFR) is overexpressed and activated in many human cancers and predicts poor patient prognosis. Targeting the kinase domain with specific EGFR tyrosine kinase inhibitors (TKIs) like...
- 6From: Oncogene. (Vol. 32, Issue 33) Peer-ReviewedThe promyelocytic leukemia (PML) protein is a tumor suppressor originally identified in acute promyelocytic leukemia and implicated in tumorigenesis in multiple forms of cancer. Here, we demonstrate that the PML protein...
- 7From: Oncogene. (Vol. 32, Issue 33) Peer-ReviewedEwing sarcoma is a pediatric bone tumor characterized in 85% of cases by the fusion between EWS and FUI genes that results in the expression of the EWS-FLI1 aberrant transcription factor. Histologically, the Ewing tumor...
- 8From: Oncogene. (Vol. 32, Issue 33) Peer-ReviewedGlioblastoma multiforme (GBM) is the most aggressive and the commonest primary brain tumor with a tendency for local invasiveness. The pathways of neoplasia, invasion and inflammation are inextricably linked in cancer...
- 9From: Oncogene. (Vol. 32, Issue 33) Peer-ReviewedThe mechanisms regulating breast cancer differentiation state are poorly understood. Of particular interest are molecular regulators controlling the highly aggressive and poorly differentiated traits of basal-like...
- 10From: Oncogene. (Vol. 32, Issue 33) Peer-ReviewedPlatelet-derived growth factor alpha (PDGFA) is frequently upregulated in various cancers and thought to function as a key player in the development and progression of tumor growth by regulating aspects of cell...
- 11From: Oncogene. (Vol. 32, Issue 33) Peer-ReviewedOvarian cancer survival rates have stagnated in the last 20 years despite the development of novel chemotherapeutic agents. Modulators of gene expression, such as histone deacetylase (HDAC) inhibitors, are among the new...
- 12From: Oncogene. (Vol. 32, Issue 33) Peer-ReviewedThe consequences of DNA damage depend on the cell type and the severity of the damage. Mild DNA damage can be repaired with or without cell-cycle arrest. More severe and irreparable DNA injury leads to the appearance of...
- 13From: Oncogene. (Vol. 32, Issue 33) Peer-ReviewedOncogene (2013) 32, 3922; doi:10.1038/onc.2012.520; published online 19 November 2012 Fernandez-L et al. (1) and Liu et al. (2) reported functional analyses of the human YAP1 gene using overexpression of its...
- 14From: Oncogene. (Vol. 32, Issue 33) Peer-ReviewedWe report on the role of hexamethylene-bis-acetamide-inducible protein 1 (HEXIM1) as an inhibitor of metastasis. HEXIM1 expression is decreased in human metastatic breast cancers when compared with matched primary...
- 15From: Oncogene. (Vol. 32, Issue 33) Peer-ReviewedWe previously identified Caliban (Clbn) as the Drosophila homolog of human Serologically defined colon cancer antigen 1 gene and demonstrated that it could function as a tumor suppressor in human non-small-cell lung...