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- 1From: Oncogene. (Vol. 31, Issue 40) Peer-ReviewedThe failure of cell proliferation to be properly regulated is a hallmark of tumourigenesis. The retinoblastoma protein (pRb) pathway represents a key component in the regulation of the cell cycle and tumour suppression....
- 2From: Oncogene. (Vol. 31, Issue 40) Peer-ReviewedLoss of tumour suppressor gene function can occur as a result of epigenetic silencing of large chromosomal regions, referred to as long-range epigenetic silencing (LRES), and genome-wide analyses have revealed that LRES...
- 3From: Oncogene. (Vol. 31, Issue 40) Peer-ReviewedIn chronic myeloid leukemia (CML), the BCR-ABL fusion oncoprotein activates multiple pathways involved in cell survival, growth promotion and disease progression. In this report, we show that the signal-transducing...
- 4From: Oncogene. (Vol. 31, Issue 40) Peer-ReviewedPreviously, we have shown a role of cytosolic NAD(P)H: quinone oxidoreductase 1 (NQO1) in the stabilization of p63 against 20S proteasomal degradation resulting in thinning of the epithelium and chemical-induced skin...
- 5From: Oncogene. (Vol. 31, Issue 40) Peer-ReviewedCorrection to: Oncogene (2012) 31, 4353-4361;published online After the publication of the article, the authors noticed two errors. First, Legend to Figure 1b was inadvertently kept in the pre-revision form. The...
- 6From: Oncogene. (Vol. 31, Issue 40) Peer-ReviewedMicrotubule-associated protein 1 light chain 3 has an important role in autophagy. The human LC3 gene family has five members, LC3A (variant-1: vl and -2: v2), LC3B, LC3B2 and LC3C. Although a form of LC3B modified by...
- 7From: Oncogene. (Vol. 31, Issue 40) Peer-ReviewedPharmacological resistance is a serious threat to the clinical success of hormone therapy for breast cancer. The antiproliferative response to antagonistic drugs such as tamoxifen (Tam) critically depends on the...
- 8From: Oncogene. (Vol. 31, Issue 40) Peer-ReviewedEpidermal growth factor receptor (EGFR)-mediated cell signaling is critical for mammary epithelial cell growth and survival; however, targeting EGFR has shown no or only minimal therapeutic benefit in patients with...