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- 1From: Oncogene. (Vol. 31, Issue 4) Peer-ReviewedCHEK2 encodes a serine/threonine kinase (Chk2) activated by ATM in response to DNA double-strand breaks. On the one hand, CHEK2 has been described as a tumor suppressor with proapoptotic, cell-cycle checkpoint and...
- 2From: Oncogene. (Vol. 31, Issue 4) Peer-ReviewedMatrix metalloproteinases (MMPs) associate with tumor progression and metastasis. We sought to investigate the role of MMP-9 from sublethally irradiated tumor in accelerated pulmonary metastasis of Lewis lung carcinoma...
- 3From: Oncogene. (Vol. 31, Issue 4) Peer-ReviewedG. Zoppoli, S. Solier, W.C. Reinhold, H. Liu, J.W. Connelly Jr., A. Monks, R.H. Shoemaker, O.D. Abaan, S.R. Davis, P.S. Meltzer, J.H. Doroshow and Y. Pommier Oncogene (2012) 31, 535-536; doi:10.1038/onc.2011.420...
- 4From: Oncogene. (Vol. 31, Issue 4) Peer-ReviewedTranscription factor RUNX3 is inactivated in a number of malignancies, including breast cancer, and is suggested to function as a tumor suppressor. How RUNX3 functions as a tumor suppressor in breast cancer remains...
- 5From: Oncogene. (Vol. 31, Issue 4) Peer-ReviewedLKB1 is a tumor susceptibility gene for the Peutz-Jeghers cancer syndrome and is a target for mutational inactivation in sporadic human malignancies. LKB1 encodes a serine/threonine kinase that has critical roles in...
- 6From: Oncogene. (Vol. 31, Issue 4) Peer-ReviewedAs invading breast carcinoma cells breach their underlying basement membrane, they become confronted with a dense three-dimensional reactive stroma dominated by type I collagen. To develop metastatic capabilities,...
- 7From: Oncogene. (Vol. 31, Issue 4) Peer-ReviewedThe serine/threonine kinase Akt is frequently activated in human cancers and is considered an attractive therapeutic target. However, the relative contributions of the different Akt isoforms to tumorigenesis, and the...
- 8From: Oncogene. (Vol. 31, Issue 4) Peer-ReviewedThe PICALM(CALM) gene, whose product is involved in clathrin-mediated endocytosis, has been identified in two recurring chromosomal translocations, involving either MLL or MLLT10 (AF10). We developed a mouse model of...
- 9From: Oncogene. (Vol. 31, Issue 4) Peer-ReviewedTrask/CDCP1 is a transmembrane glycoprotein widely expressed in epithelial tissues whose functions are just beginning to be understood, but include a role as an antiadhesive effector of Src kinases. Early studies...
- 10From: Oncogene. (Vol. 31, Issue 4) Peer-ReviewedChemotherapy has been reported to induce epithelial-mesenchymal transition (EMT) in tumor cells, which is a critical step in the process of metastasis leading to cancer spreading and treatment failure. However, the...
- 11From: Oncogene. (Vol. 31, Issue 4) Peer-ReviewedFusion proteins containing the amino terminus of mixed lineage leukemia (MLL) are common in acute lymphoblastic leukemia (ALL) due to translocations. The MLL-AF4 fusion protein is generated by the translocation...
- 12From: Oncogene. (Vol. 31, Issue 4) Peer-ReviewedIdentifying the spectrum of genetic alterations that cooperate with critical oncogenes to promote transformation provides a foundation for understanding the diversity of clinical phenotypes observed in human cancers....