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- 1From: Oncogene. (Vol. 31, Issue 26) Peer-ReviewedEpithelial-mesenchymal transition (EMT) is a crucial event in wound healing, tissue repair and cancer progression in adult tissues. We have recently shown that transforming growth factor (TGF)-[beta]-induced EMT...
- 2From: Oncogene. (Vol. 31, Issue 26) Peer-ReviewedThe aspartic protease cathepsin-D (cath-D) is a marker of poor prognosis in breast cancer that is overexpressed and hypersecreted by human breast cancer cells. Secreted pro-cath-D binds to the extracellular domain of...
- 3From: Oncogene. (Vol. 31, Issue 26) Peer-ReviewedThe intrinsic mitochondrial apoptotic pathway acts through two core pro-apoptotic proteins Bax (Bcl2-associated X protein) and Bak (Bcl2-antagonist/killer 1). Although Bax and Bak seem to have redundant roles in...
- 4From: Oncogene. (Vol. 31, Issue 26) Peer-ReviewedMULTIMERIN2 (MMRN2), also known as Endoglyx-1, is an extracellular matrix glycoprotein whose function has so far remained elusive. Given its specific localization in tight association with the endothelium we...
- 5From: Oncogene. (Vol. 31, Issue 26) Peer-ReviewedHere we show that pemetrexed-treated mesothelioma cells undergo accelerated senescence. This is characterized by the secretion of proinflammatory and mitogenic cytokines, reminiscent of an SASP (senescence-associated...
- 6From: Oncogene. (Vol. 31, Issue 26) Peer-ReviewedPituitary tumor transforming gene (PTTG) is a well-studied oncogene for its role in tumorigenesis and serves as a marker of malignancy in several cancer types including lung. In the present study, we defined the role of...
- 7From: Oncogene. (Vol. 31, Issue 26) Peer-ReviewedThe mechanisms by which chronic inflammatory lung diseases, particularly chronic obstructive pulmonary disease, confer enhanced risk for lung cancer are not welldefined. To investigate whether nuclear factor...
- 8From: Oncogene. (Vol. 31, Issue 26) Peer-ReviewedChitinase 3-like 1 (CHI3L1), one of the mammalian members of the chitinase family, is expressed in several types of human cancer, and elevated serum level of CHI3L1 is suggested to be a biomarker of poor prognosis in...