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- 1From: Oncogene. (Vol. 31, Issue 13) Peer-ReviewedThe tyrosine kinase c-Src is upregulated in various human cancers; however, the molecular mechanisms underlying c-Src-mediated tumor progression remain unclear. Here we show that downregulation of microRNA (miR)-542-3p...
- 2From: Oncogene. (Vol. 31, Issue 13) Peer-ReviewedCAPC, also known as LRRC26, is expressed in normal prostate and salivary gland. We developed a mAb to CAPC and used it to characterize the protein and study its function. CAPC protein was detected in normal prostate and...
- 3From: Oncogene. (Vol. 31, Issue 13) Peer-ReviewedDesmoglein-2 (Dsg2) is a desmosomal cadherin that is aberrantly expressed in human skin carcinomas. In addition to its well-known role in mediating intercellular desmosomal adhesion, Dsg2 regulates mitogenic signaling...
- 4From: Oncogene. (Vol. 31, Issue 13) Peer-ReviewedThe anti-VEGF targeted antibody bevacizumab (BVZ) has been approved for treating renal cell carcinomas (RCCs). Although BVZ increases the progression-free survival of patients with metastatic RCC, the effect on overall...
- 5From: Oncogene. (Vol. 31, Issue 13) Peer-ReviewedInflammatory bowel disease (IBD) is an important etiologic factor in the development of colorectal cancer. However, the mechanism underlying carcinogenesis through chronic inflammation is still unknown....
- 6From: Oncogene. (Vol. 31, Issue 13) Peer-ReviewedMicroRNAs (miRNAs) are recognized as being central players in many biological processes and cellular pathways. Their roles in disease have been highlighted first by observation of their aberrant expression profiles in...
- 7From: Oncogene. (Vol. 31, Issue 13) Peer-ReviewedThe transition from quiescence to proliferation is a key regulatory step that can be induced by serum stimulation in cultured fibroblasts. The transcription factor Myc is directly induced by serum mitogens and drives a...
- 8From: Oncogene. (Vol. 31, Issue 13) Peer-ReviewedDestruction of insulin-producing pancreatic [beta]-cells by local autoimmune inflammation is a hallmark of type 1 diabetes. Histochemical analysis of pancreases from non-obese diabetic mice indicated activation of the...
- 9From: Oncogene. (Vol. 31, Issue 13) Peer-ReviewedMerlin is a tumour suppressor involved in the development of a variety of tumours including mesotheliomas. Neurofibromatosis type 2 (NF2), a dominantly inherited tumour disease, is also caused by loss of merlin. NF2...
- 10From: Oncogene. (Vol. 31, Issue 13) Peer-ReviewedErythropoietin (Epo) is widely used clinically to treat anemia associated with various clinical conditions including cancer. Data from several clinical trials suggest significant adverse effect of Epo treatment on...
- 11From: Oncogene. (Vol. 31, Issue 13) Peer-ReviewedCHK1 and CHK2 function as effectors of cell cycle checkpoint arrest following DNA damage. Small molecule inhibitors of CHK proteins are under clinical evaluation in combination with chemotherapeutic agents known to...