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- 1From: Journal of Experimental & Clinical Cancer Research. (Vol. 31, Issue 1) Peer-ReviewedBackground Vascular endothelial growth factor (VEGF) is a signal protein produced by cells that stimulates vasculogenesis and angiogenesis. VEGF is believed to implicate poor prognosis in various cancers. The...
- 2From: Journal of Experimental & Clinical Cancer Research. (Vol. 31) Peer-ReviewedObjective This study aims to investigate the in vitro effects of Ulinastatin (UTI) and Taxotere (TXT) on cell proliferation; cell apoptosis; xenografted tumor growth; and expression of insulin-like growth factor...
- 3From: Journal of Experimental & Clinical Cancer Research. (Vol. 31, Issue 1) Peer-ReviewedMesothelin, a secreted protein, is overexpressed in some cancers, including pancreatic cancer. Rescent studies have shown that overexpression of mesothelin significantly increased tumor cell proliferation, and...
- 4From: Journal of Experimental & Clinical Cancer Research. (Vol. 31) Peer-ReviewedBackground The nucleosome binding protein 1 (HMGN5/NSBP1) is a member of the HMGN protein family and is highly expressed in several kinds of cancer. Nevertheless, the role of NSBP1 in clear cell renal cell carcinoma...
- 5From: Journal of Experimental & Clinical Cancer Research. (Vol. 31, Issue 1) Peer-ReviewedObjective p73 and p63 are two structural and functional homologs of p53, and their biological functions in cancer progression have attracted attention due to the presence of variants generated by genetic...
- 6From: Journal of Experimental & Clinical Cancer Research. (Vol. 31) Peer-ReviewedBackground Epithelial ovarian cancer (EOC) is one of the leading causes of cancer deaths in women worldwide. Adrenomedullin (AM) is a multifunctional peptide which presents in various kinds of tumors. Methods...
- 7From: Journal of Experimental & Clinical Cancer Research. (Vol. 31, Issue 1) Peer-ReviewedHomeodomain-interacting protein kinase 2 (HIPK2) is a multitalented protein that exploits its kinase activity to modulate key molecular pathways in cancer to restrain tumor growth and induce response to therapies. HIPK2...
- 8From: Journal of Experimental & Clinical Cancer Research. (Vol. 31, Issue 1) Peer-ReviewedBackground Acquired radioresistance of cancer cells remains a fundamental barrier to attaining the maximal efficacy of radiotherapy for the treatment of breast cancer. Anti-apoptotic proteins, such as Bcl-2 and...
- 9From: Journal of Experimental & Clinical Cancer Research. (Vol. 31, Issue 1) Peer-ReviewedBackground Exposure to anthracyclines (ANT) during childhood represents a high risk for development of late cardiotoxicity. Cardiotoxicity is usually detected only when clinical symptoms or progressive cardiac...
- 10From: Journal of Experimental & Clinical Cancer Research. (Vol. 31, Issue 1) Peer-ReviewedBackground In recent decades, melanoma incidence has been increasing in European countries; in 2006, there were approximately 60,000 cases leading to 13,000 deaths. Within Europe there is some geographical variation...
- 11From: Journal of Experimental & Clinical Cancer Research. (Vol. 31, Issue 1) Peer-ReviewedBackground Where population coverage is limited, the exclusive use of Cancer Registries might limit ascertainment of incident cancer cases. We explored the potentials of Nationwide hospital discharge records (NHDRs)...
- 12From: Journal of Experimental & Clinical Cancer Research. (Vol. 31, Issue 1) Peer-ReviewedBackground Aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor associated with gastric carcinogenesis. 3,3'-Diindolylmethane (DIM) is a relatively non-toxic selective AhR modulator. This study...
- 13From: Journal of Experimental & Clinical Cancer Research. (Vol. 31) Peer-ReviewedBackground Xenografts have been shown to provide a suitable source of tumor tissue for molecular analysis in the absence of primary tumor material. We utilized ES xenograft series for integrated microarray analyses...
- 14From: Journal of Experimental & Clinical Cancer Research. (Vol. 31, Issue 1) Peer-ReviewedBackground Expression levels of CD133, a cancer stem cell marker, and of the [alpha]-subunit of the dystroglycan ([alpha]-DG) complex, have been previously reported to be altered in colorectal cancers. Methods...
- 15From: Journal of Experimental & Clinical Cancer Research. (Vol. 31, Issue 1) Peer-ReviewedProlyl hydroxylase domain 3 (PHD3) is a hypoxia inducible factor-[alpha] (HIF[alpha]) regulator; it degrades HIF[alpha] in the presence of oxygen. Recently, there have been an increasing number of studies about the role...
- 16From: Journal of Experimental & Clinical Cancer Research. (Vol. 31, Issue 1) Peer-ReviewedBackground Baicalin, a flavone present in Scutellaria baicalensis Georgi, inhibits the growth of human leukemia and myeloma cells through induction of apoptosis. Methods The present study was undertaken to...
- 17From: Journal of Experimental & Clinical Cancer Research. (Vol. 31, Issue 1) Peer-ReviewedBackground Although hypoxia is known to promote hepatoma cell invasion and migration, little is known regarding the molecular mechanisms of this process. Our previous research showed that loss of Tg737 is associated...
- 18From: Journal of Experimental & Clinical Cancer Research. (Vol. 31, Issue 1) Peer-Reviewed
Claudin-5 is involved in breast cancer cell motility through the N-WASP and ROCK signalling pathways
Background Recent studies have shown dysregulation in TJ structure of several cancers including breast. Claudin-5 is a protein member of the TJ structure expressed in both endothelial and epithelial cells. This study... - 19From: Journal of Experimental & Clinical Cancer Research. (Vol. 31) Peer-ReviewedBackground SPC-c-Raf-1-BxB transgenic mice develop genetically induced disseminated lung adenocarcinoma allowing examination of carcinogenesis and evaluation of novel treatment strategies. We report on assessment of...
- 20From: Journal of Experimental & Clinical Cancer Research. (Vol. 31, Issue 1) Peer-ReviewedBackground LATS1 is a tumor suppressor genes implicated in the pathogenesis of certain types of tumors, but its role is not known in human glioma. Methods Using real-time PCR and immunohistochemistry, we...