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- 1From: Journal of Experimental & Clinical Cancer Research. (Vol. 30) Peer-ReviewedBackground To elucidate whether rapamycin, the inhibitor of mTOR (mammalian target of rapamycin), can potentiate the cytotoxic effect of docetaxel in lung cancer cells and to probe the mechanism underlying such...
- 2From: Journal of Experimental & Clinical Cancer Research. (Vol. 30) Peer-ReviewedIncreased polyamine concentrations in the blood and urine of cancer patients reflect the enhanced levels of polyamine synthesis in cancer tissues arising from increased activity of enzymes responsible for polyamine...
- 3From: Journal of Experimental & Clinical Cancer Research. (Vol. 30) Peer-ReviewedOver-expressed in numerous cancers, Ubiquitin-like containing PHD Ring Finger 1 (UHRF1, also known as ICBP90 or Np95) is characterized by a SRA domain (Set and Ring Associated) which is found only in the UHRF family....
- 4From: Journal of Experimental & Clinical Cancer Research. (Vol. 30) Peer-ReviewedBackground This retrospective analysis is focused on the efficacy and safety of radioimmunotherapy (RIT) with Zevalin.sup.[R] .sup.in nine patients with recurrent follicular lymphoma (FL) who were treated in a...
- 5From: Journal of Experimental & Clinical Cancer Research. (Vol. 30) Peer-ReviewedIntroduction The inflammatory enzyme indoleamine 2, 3-dioxygenase (IDO) participates in immune tolerance and promotes immune escape of IDO+ tumors. A recent hypothesis suggested that IDO may contribute to the...
- 6From: Journal of Experimental & Clinical Cancer Research. (Vol. 30) Peer-ReviewedProtein kinase C epsilon (PKC[epsilon]), an oncogene overexpressed in several human cancers, is involved in cell proliferation, migration, invasion, and survival. However, its roles in clear cell renal cell carcinoma...
- 7From: Journal of Experimental & Clinical Cancer Research. (Vol. 30) Peer-ReviewedBackground Circulating levels of novel long-chain hydroxy fatty acids (called GTAs) were recently discovered in the serum of healthy subjects which were shown to be reduced in subjects with colorectal cancer (CRC),...
- 8From: Journal of Experimental & Clinical Cancer Research. (Vol. 30) Peer-ReviewedBackground DNA methylation has been widely used in classification, early diagnosis, therapy and prediction of metastasis as well as recurrence of cervical cancer. DNMT methyltransferase 1 (DNMT1), which plays a...
- 9From: Journal of Experimental & Clinical Cancer Research. (Vol. 30) Peer-ReviewedBackground To examine the expression of SMAD4 at gene and protein levels in glioma samples with different WHO grades and its association with survival. Methods Two hundreds fifty-two glioma specimens and 42...
- 10From: Journal of Experimental & Clinical Cancer Research. (Vol. 30) Peer-ReviewedBackground MDR1 gene encoding P-glycoprotein is an ATP-dependent drug efflux transporter and related to drug resistance of yolk sac carcinoma. Ultrasound microbubble-mediated delivery has been used as a novel and...
- 11From: Journal of Experimental & Clinical Cancer Research. (Vol. 30) Peer-ReviewedBackground To evaluate the expression of EGFR and COX-2 and their correlation with prognosis in NSCLC Methods The paraffin embedded tumor samples of 50 NSCLC patients receiving radical resection were analyzed...
- 12From: Journal of Experimental & Clinical Cancer Research. (Vol. 30) Peer-ReviewedHypoxia inducible factor-1 (HIF-1) has been considered as a critical transcriptional factor in response to hypoxia. It can increase P-glycoprotein (P-Gp) thus generating the resistant effect to chemotherapy. At present,...
- 13From: Journal of Experimental & Clinical Cancer Research. (Vol. 30) Peer-ReviewedBackground The pathogenic role of beta-HPVs in non melanoma skin cancer (NMSC), is not still completely understood, and literature data indicate that they might be at least cofactors in the development of certain...
- 14From: Journal of Experimental & Clinical Cancer Research. (Vol. 30) Peer-ReviewedBackground Hedgehog (Hh) signaling pathway is involved in regulation of many tissues development and oncogenesis. Recently, Hh signaling has been identified as a required functional pathway for leukemia stem...
- 15From: Journal of Experimental & Clinical Cancer Research. (Vol. 30) Peer-ReviewedBackground Overall therapeutic outcomes of advanced non-small-cell lung cancer (NSCLC) are poor. The dendritic cell (DC) immunotherapy has been developed as a new strategy for the treatment of lung cancer. The...
- 16From: Journal of Experimental & Clinical Cancer Research. (Vol. 30) Peer-ReviewedBackground MRI plays a key role in the preclinical development of new drugs, diagnostics and their delivery systems. However, very high installation and running costs of existing superconducting MRI machines limit...
- 17From: Journal of Experimental & Clinical Cancer Research. (Vol. 30) Peer-ReviewedBackground Iodine 125 (.sup.125.sup.I) seed irradiation is an effective treatment for unresectable pancreatic cancers. However, the radiobiological mechanisms underlying brachytherapy remain unclear. Therefore, we...
- 18From: Journal of Experimental & Clinical Cancer Research. (Vol. 30) Peer-ReviewedStem cells are a relevant source of information about cellular differentiation, molecular processes and tissue homeostasis, but also one of the most putative biological tools to treat degenerative diseases. This review...
- 19From: Journal of Experimental & Clinical Cancer Research. (Vol. 30) Peer-ReviewedObjective To investigate the effects of ulinastatin and docetaxel on invasion of breast cancer cells and expression of uPA, uPAR and ERK, breast cancer MDA-MB-231 and MCF-7 cells. Methods The nude mice were...
- 20From: Journal of Experimental & Clinical Cancer Research. (Vol. 30) Peer-ReviewedBackground Cancer gene therapy by retroviral vectors is mainly limited by the level of transduction. Retroviral gene transfer requires target cell division. Cell synchronization, obtained by drugs inducing a...