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- 1From: PLoS Genetics. (Vol. 3, Issue 7) Peer-ReviewedABSTRACT We review three approaches to the genetic analysis of the biology and pathobiology of human aging. The first and so far the best-developed is the search for the biochemical genetic basis of varying...
- 2From: PLoS Genetics. (Vol. 3, Issue 7) Peer-ReviewedMultilocus analysis of single nucleotide polymorphism haplotypes is a promising approach to dissecting the genetic basis of complex diseases. We propose a coalescent-based model for association mapping that potentially...
- 3From: PLoS Genetics. (Vol. 3, Issue 7) Peer-ReviewedThe histone H3 variant CENP-A assembles into chromatin exclusively at centromeres. The process of CENP-A chromatin assembly is epigenetically regulated. Fission yeast centromeres are composed of a central kinetochore...
- 4From: PLoS Genetics. (Vol. 3, Issue 7) Peer-ReviewedThe modern synthetic view of human evolution proposes that the fixation of novel mutations is driven by the balance among selective advantage, selective disadvantage, and genetic drift. When considering the global...
- 5From: PLoS Genetics. (Vol. 3, Issue 7) Peer-ReviewedTo explore the link between DNA damage and gene silencing, we induced a DNA double-strand break in the genome of Hela or mouse embryonic stem (ES) cells using I-SceI restriction endonuclease. The I-SceI site lies within...
- 6From: PLoS Genetics. (Vol. 3, Issue 7) Peer-ReviewedWe introduce a new framework for the analysis of association studies, designed to allow untyped variants to be more effectively and directly tested for association with a phenotype. The idea is to combine knowledge on...
- 7From: PLoS Genetics. (Vol. 3, Issue 7) Peer-ReviewedIdiopathic epilepsy is a common human disorder with a strong genetic component, usually exhibiting complex inheritance. We describe a new mouse mutation in C57BL/6J mice, called frequent-flyer (Ff), in which disruption...
- 8From: PLoS Genetics. (Vol. 3, Issue 7) Peer-ReviewedThe obesity epidemic is responsible for a substantial economic burden in developed countries and is a major risk factor for type 2 diabetes and cardiovascular disease. The disease is the result not only of several...
- 9From: PLoS Genetics. (Vol. 3, Issue 7) Peer-ReviewedThe genetic background of complex diseases is proposed to consist of several low-penetrance risk loci. Addressing this complexity likely requires both large sample size and simultaneous analysis of different predisposing...
- 10From: PLoS Genetics. (Vol. 3, Issue 7) Peer-ReviewedWe describe here the Drosophila gene hydra that appears to have originated de novo in the melanogaster subgroup and subsequently evolved in both structure and expression level in Drosophila melanogaster and its sibling...
- 11From: PLoS Genetics. (Vol. 3, Issue 7) Peer-ReviewedThe p53 tumor suppressor is a sequence-specific pleiotropic transcription factor that coordinates cellular responses to DNA damage and stress, initiating cell-cycle arrest or triggering apoptosis. Although the human p53...
- 12From: PLoS Genetics. (Vol. 3, Issue 7) Peer-ReviewedThe Drosophila gene aid encodes the fly ortholog of mps1, a conserved kinetochore-associated protein kinase required for the meiotic and mitotic spindle assembly checkpoints. Using live imaging, we demonstrate that...
- 13From: PLoS Genetics. (Vol. 3, Issue 7) Peer-ReviewedInsulator or enhancer-blocking elements are proposed to play an important role in the regulation of transcription by preventing inappropriate enhancer/promoter interaction. The zinc-finger protein CTCF is well studied in...
- 14From: PLoS Genetics. (Vol. 3, Issue 7) Peer-ReviewedRapid progress in exploring the human and mouse genome has resulted in the generation of a multitude of mouse models to study gene functions in their biological context. However, effective screening methods that allow...
- 15From: PLoS Genetics. (Vol. 3, Issue 7) Peer-ReviewedHomologous recombination between circular sister chromosomes during DNA replication in bacteria can generate chromosome dimers that must be resolved into monomers prior to cell division. In Escherichia coli, dimer...
- 16From: PLoS Genetics. (Vol. 3, Issue 7) Peer-ReviewedMaize (Zea mays L.) is one of the most important cereal crops and a model for the study of genetics, evolution, and domestication. To better understand maize genome organization and to build a framework for genome...
- 17From: PLoS Genetics. (Vol. 3, Issue 7) Peer-ReviewedDuring primordial germ cell (PGC) development, epigenetic reprogramming events represented by X chromosome reactivation and erasure of genomic imprinting are known to occur. Although precise timing is not given, X...
- 18From: PLoS Genetics. (Vol. 3, Issue 7) Peer-Reviewed
Correction: discovery and analysis of evolutionarily conserved intronic splicing regulatory elements
10.1371/journal.pgen.0030085 In PLoS Genetics, volume 3, issue 5: Mr. Eric L. Van Nostrand's name was incorrectly listed in the online citation as Nostrand ELV. The correct citation is: Yeo GW, Van Nostrand EL,...