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- 1From: PLoS Medicine. (Vol. 3, Issue 7) Peer-ReviewedABSTRACT Background Despite the existence of effective drug treatments, tuberculosis (TB) causes 2 million deaths annually worldwide. Effective treatment is complicated by multidrug-resistant TB (MDR TB) strains that...
- 2From: PLoS Medicine. (Vol. 3, Issue 7) Peer-ReviewedPublic concern about ethics in HIV-prevention trials intensified in the last 18 months, reaching a flashpoint that resulted in the halting of two clinical trials to test the efficacy of tenofovir as a possible method of...
- 3From: PLoS Medicine. (Vol. 3, Issue 7) Peer-ReviewedABSTRACT Background Most, if not all, of the cellular functions of the BRCA1 protein are mediated through heterodimeric complexes composed of BRCA1 and a related protein, BARD1. Some breast-cancer-associated BRCA1...
- 4From: PLoS Medicine. (Vol. 3, Issue 7) Peer-ReviewedABSTRACT Background The Botswana government recently implemented a policy of routine or "opt-out" HIV testing in response to the high prevalence of HIV infection, estimated at 37% of adults. Methods and Findings...
- 5From: PLoS Medicine. (Vol. 3, Issue 7) Peer-ReviewedIn 2002 cancer accounted for 16.7% of the total burden of disease in the European Union (EU), compared with 25.3% and 17.1% for mental health and cardiovascular diseases, respectively [1]. In the period relevant to this...
- 6From: PLoS Medicine. (Vol. 3, Issue 7) Peer-ReviewedArticle Summary Antidepressants are assumed to work on the specific neurobiology of depressive disorders according to a "disease-centred" model of drug action. However, little evidence supports this idea. An...
- 7From: PLoS Medicine. (Vol. 3, Issue 7) Peer-ReviewedABSTRACT Background The von Hippel-Lindau tumour suppressor protein-hypoxia-inducible factor (VHL-HIF) pathway has attracted widespread medical interest as a transcriptional system controlling cellular responses to...
- 8From: PLoS Medicine. (Vol. 3, Issue 7) Peer-ReviewedABSTRACT Background A randomized controlled trial (RCT) has shown that male circumcision (MC) reduces sexual transmission of HIV from women to men by 60% (32%-76%; 95% CI) offering an intervention of proven efficacy...
- 9From: PLoS Medicine. (Vol. 3, Issue 7) Peer-ReviewedABSTRACT Background Cigarette smuggling is a major public health issue, stimulating increased tobacco consumption and undermining tobacco control measures. China is the ultimate prize among tobacco's emerging...
- 10From: PLoS Medicine. (Vol. 3, Issue 7) Peer-ReviewedBackground to the debate: An important mechanism for protecting human research participants is the prior approval of a clinical study by a research ethics board, known in the United States as an institutional review...
- 11From: PLoS Medicine. (Vol. 3, Issue 7) Peer-ReviewedDOI: 10.1371/journal.pmed.0030130 In PLoS Medicine, volume 3, issue 6: Table 2 should have included the following information about the CMAJ (Canadian Medical Association Journal): frequency of publication, twice a...
- 12From: PLoS Medicine. (Vol. 3, Issue 7) Peer-ReviewedABSTRACT Background A Phase I clinical trial has been proposed that uses neutralising monoclonal antibodies (MAbs) as passive immunoprophylaxis to prevent mother-to-child transmission of HIV-1 in South Africa. To...
- 13From: PLoS Medicine. (Vol. 3, Issue 7) Peer-ReviewedIn PLoS Medicine's launch issue in 2004, we declared that we would not be part of "the cycle of dependency that has formed between journals and the pharmaceutical industry" (DOI: 10.1371/journal.pmed.0010022). We set out...
- 14From: PLoS Medicine. (Vol. 3, Issue 7) Peer-ReviewedNepal is one of the poorest countries in the world, with a per capita gross national product of US$240. Nearly 40% of the 25 million people living in Nepal do so on less than a dollar a day [1]. About 90% of the...
- 15From: PLoS Medicine. (Vol. 3, Issue 7) Peer-ReviewedThe Prize China has long been identified as the most important international cigarette market, now and in the future--O'Sullivan and Chapman called China the "ultimate prize" among the world's emerging tobacco markets...
- 16From: PLoS Medicine. (Vol. 3, Issue 7) Peer-ReviewedIn her recent PLoS Medicine article, Christine Phillips writes: "ADHD [attention deficit hyperactivity disorder] joins dyslexia and glue ear as disorders that are considered significant primarily because of their effects...
- 17From: PLoS Medicine. (Vol. 3, Issue 7) Peer-ReviewedABSTRACT Background A chikungunya virus outbreak of unprecedented magnitude is currently ongoing in Indian Ocean territories. In Reunion Island, this alphavirus has already infected about one-third of the human...
- 18From: PLoS Medicine. (Vol. 3, Issue 7) Peer-ReviewedABSTRACT Background Transplantation of embryonic pig pancreatic tissue as a source of insulin has been suggested for the cure of diabetes. However, previous limited clinical trials failed in their attempts to treat...
- 19From: PLoS Medicine. (Vol. 3, Issue 7) Peer-ReviewedThe Ptolemy Project (http:/ www.ptolemy.ca) is a recently developed model of electronic access to medical literature for surgeons in developing countries. The program provides for East African surgeons to become research...
- 20From: PLoS Medicine. (Vol. 3, Issue 7) Peer-ReviewedWith more than 6 million HIV positive individuals--the highest of any country in the world--South Africa is the epicentre of the HIV/AIDS pandemic. In much of sub-Saharan Africa, especially South Africa, the HIV/AIDS...