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- Search Terms:ISSN: 15537390AndISSN: 15537404AndVolume Number: 3AndIssue Number: 6AndStart Page: e90AndDate: 2007 Revise Search
- 1From: PLoS Genetics. (Vol. 3, Issue 6) Peer-ReviewedIn most eukaryotes, the prophase of the first meiotic division is characterized by a high level of homologous recombination between homologous chromosomes. Recombination events are not distributed evenly within the...
- 2From: PLoS Genetics. (Vol. 3, Issue 6) Peer-ReviewedThe balance of quiescence and cell division is critical for tissue homeostasis and organismal health. Serum stimulation of fibroblasts is well studied as a classic model of entry into the cell division cycle, but the...
- 3From: PLoS Genetics. (Vol. 3, Issue 6) Peer-ReviewedThe establishment of a single cell type regeneration paradigm in the zebrafish provides an opportunity to investigate the genetic mechanisms specific to regeneration processes. We previously demonstrated that...
- 4From: PLoS Genetics. (Vol. 3, Issue 6) Peer-ReviewedTwin cohorts provide a unique advantage for investigations of the role of genetics and environment in the etiology of variation in common complex traits by reducing the variance due to environment, age, and cohort...
- 5From: PLoS Genetics. (Vol. 3, Issue 6) Peer-ReviewedProgesterone and estrogen are critical regulators of uterine receptivity. To facilitate uterine remodeling for embryo attachment, estrogen activity in the uterine epithelia is attenuated by progesterone; however, the...
- 6From: PLoS Genetics. (Vol. 3, Issue 6) Peer-ReviewedIdentifying genomic locations that have experienced selective sweeps is an important first step toward understanding the molecular basis of adaptive evolution. Using statistical methods that account for the confounding...
- 7From: PLoS Genetics. (Vol. 3, Issue 6) Peer-ReviewedMutational robustness is defined as the constancy of a phenotype in the face of deleterious mutations. Whether robustness can be directly favored by natural selection remains controversial. Theory and in silico...
- 8From: PLoS Genetics. (Vol. 3, Issue 6) Peer-ReviewedThe Genographic Project is studying the genetic signatures of ancient human migrations and creating an open-source research database. It allows members of the public to participate in a real-time anthropological genetics...
- 9From: PLoS Genetics. (Vol. 3, Issue 6) Peer-ReviewedMinor histocompatibility (H) antigens are allogeneic target molecules having significant roles in alloimmune responses after human leukocyte antigen-matched solid organ and stem cell transplantation (SCT). Minor H...
- 10From: PLoS Genetics. (Vol. 3, Issue 6) Peer-ReviewedType 2 diabetes mellitus is a complex disorder associated with multiple genetic, epigenetic, developmental, and environmental factors. Animal models of type 2 diabetes differ based on diet, drug treatment, and gene...
- 11From: PLoS Genetics. (Vol. 3, Issue 6) Peer-ReviewedUsing a chromatin immunoprecipitation-paired end diTag cloning and sequencing strategy, we mapped estrogen receptor α (ERα) binding sites in MCF-7 breast cancer cells. We identified 1,234 high confidence binding clusters...
- 12From: PLoS Genetics. (Vol. 3, Issue 6) Peer-ReviewedThe Saccharomyces cerevisiae Pif1p helicase is a negative regulator of telomere length that acts by removing telomerase from chromosome ends. The catalytic subunit of yeast telomerase, Est2p, is telomere associated...
- 13From: PLoS Genetics. (Vol. 3, Issue 6) Peer-ReviewedWe performed a genome-scale chromatin immunoprecipitation (ChIP)-chip comparison of two modifications (trimethylation of lysine 9 [H3me3K9] and trimethylation of lysine 27 [H3me3K27]) of histone H3 in Ntera2 testicular...
- 14From: PLoS Genetics. (Vol. 3, Issue 6) Peer-ReviewedAlternative splicing of genes is an efficient means of generating variation in protein function. Several disease states have been associated with rare genetic variants that affect splicing patterns. Conversely, splicing...
- 15From: PLoS Genetics. (Vol. 3, Issue 6) Peer-ReviewedABSTRACT Conventional gene therapy has focused largely on gene replacement in target cells. However, progress from basic research to the clinic has been slow for reasons relating principally to the challenges of...
- 16From: PLoS Genetics. (Vol. 3, Issue 6) Peer-ReviewedWhile major inroads have been made in identifying the genetic causes of rare Mendelian disorders, little progress has been made in the discovery of common gene variations that predispose to complex diseases. The single...
- 17From: PLoS Genetics. (Vol. 3, Issue 6) Peer-ReviewedMicroarrays enable comparative analyses of gene expression on a genomic scale, however these experiments frequently identify an abundance of differentially expressed genes such that it may be difficult to identify...
- 18From: PLoS Genetics. (Vol. 3, Issue 6) Peer-ReviewedThe glucocorticoid receptor (GR) associates with glucocorticoid response elements (GREs) and regulates selective gene transcription in a cell-specific manner. Native GREs are typically thought to be composite elements...
- 19From: PLoS Genetics. (Vol. 3, Issue 6) Peer-ReviewedWe observed a severe autosomal recessive movement disorder in mice used within our laboratory. We pursued a series of experiments to define the genetic lesion underlying this disorder and to identify a cognate disease in...
- 20From: PLoS Genetics. (Vol. 3, Issue 6) Peer-ReviewedThe yeast "remodels the structure of chromatin" (RSC) complex is a multi-subunit "switching deficient/sucrose nonfermenting" type ATP-dependent nucleosome remodeler, with human counterparts that are well-established...