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- Search Terms:ISSN: 1553734XAndISSN: 15537358AndVolume Number: 3AndIssue Number: 6AndStart Page: e110AndDate: 2007 Revise Search
- 1From: PLoS Computational Biology. (Vol. 3, Issue 6) Peer-ReviewedMorphology typically enhances the fidelity of sensory systems. Sharks, skates, and rays have a well-developed electrosense that presents strikingly unique morphologies. Here, we model the dynamics of the peripheral...
- 2From: PLoS Computational Biology. (Vol. 3, Issue 6) Peer-ReviewedIntroduction Sages have observed that society often honors its living conformists and its dead innovators; "but we prefer to honor living innovators," says Thomas Lengauer, professor of computational biology, director...
- 3From: PLoS Computational Biology. (Vol. 3, Issue 6) Peer-ReviewedReceptors constitute the interface of cells to their external environment. These molecules bind specific ligands involved in multiple processes, such as signal transduction and nutrient transport. Although a variety of...
- 4From: PLoS Computational Biology. (Vol. 3, Issue 6) Peer-ReviewedCell polarity is a general cellular process that can be seen in various cell types such as migrating neutrophils and Dictyostelium cells. The Rho small GTP(guanosine 5'-tri phosphate)ases have been shown to regulate cell...
- 5From: PLoS Computational Biology. (Vol. 3, Issue 6) Peer-ReviewedThe role of stochasticity on gene expression is widely discussed. Both potential advantages and disadvantages have been revealed. In some systems, noise in gene expression has been quantified, in among others the lac...
- 6From: PLoS Computational Biology. (Vol. 3, Issue 6) Peer-ReviewedIntroduction The term machine learning refers to a set of topics dealing with the creation and evaluation of algorithms that facilitate pattern recognition, classification, and prediction, based on models derived from...
- 7From: PLoS Computational Biology. (Vol. 3, Issue 6) Peer-ReviewedResidue interaction networks and loop motions are important for catalysis in clihydrofolate reductase (DHFR). Here, we investigate the effects of ligand binding and chain connectivity on network communication in DHFR. We...
- 8From: PLoS Computational Biology. (Vol. 3, Issue 6) Peer-ReviewedGenomic DNA copy-number alterations (CNAs) are associated with complex diseases, including cancer: CNAs are indeed related to tumoral grade, metastasis, and patient survival. CNAs discovered from array-based comparative...
- 9From: PLoS Computational Biology. (Vol. 3, Issue 6) Peer-ReviewedMany pathogens are able to manipulate the signaling pathways responsible for the generation of host immune responses. Here we examine and model a respiratory infection system in which disruption of host immune functions...
- 10From: PLoS Computational Biology. (Vol. 3, Issue 6) Peer-ReviewedAdvances in the computational identification of functional noncoding polymorphisms will aid in cataloging novel determinants of health and identifying genetic variants that explain human evolution. To date, however, the...
- 11From: PLoS Computational Biology. (Vol. 3, Issue 6) Peer-ReviewedIn 1995, when I left a faculty position at the University of Pennsylvania to join the fledgling bioinformatics unit at what was then SmithKline Beecham Pharmaceuticals, the friendly jibes by academic colleagues about...
- 12From: PLoS Computational Biology. (Vol. 3, Issue 6) Peer-ReviewedMany complex networks such as computer and social networks exhibit modular structures, where links between nodes are much denser within modules than between modules. It is widely believed that cellular networks are also...
- 13From: PLoS Computational Biology. (Vol. 3, Issue 6) Peer-ReviewedIntroduction PLoS Computational Biology is the official journal of the International Society for Computational Biology (ISCB), a partnership that was formed during the Journal's conception in 2005. With ISCB being the...
- 14From: PLoS Computational Biology. (Vol. 3, Issue 6) Peer-ReviewedOur nervous system can efficiently recognize objects in spite of changes in contextual variables such as perspective or lighting conditions. Several lines of research have proposed that this ability for invariant...
- 15From: PLoS Computational Biology. (Vol. 3, Issue 6) Peer-ReviewedThis work examines the computational architecture used by the brain during the analysis of the spectral envelope of sounds, an important acoustic feature for defining auditory objects. Dynamic causal modelling and...
- 16From: PLoS Computational Biology. (Vol. 3, Issue 6) Peer-ReviewedIn mammals, circadian periodicity has been described for gene expression in the hypothalamus and multiple peripheral tissues. It is accepted that 10%-15% of all genes oscillate in a daily rhythm, regulated by an...
- 17From: PLoS Computational Biology. (Vol. 3, Issue 6) Peer-ReviewedStrong experimental evidence indicates that protein kinase and phosphatase (KP) cycles are critical to both the induction and maintenance of activity-dependent modifications in neurons. However, their contribution to...
- 18From: PLoS Computational Biology. (Vol. 3, Issue 6) Peer-ReviewedThe identification of cell cycle-related genes is still a difficult task, even for organisms with relatively few genes such as the fission yeast. Several gene expression studies have been published on S. pombe showing...
- 19From: PLoS Computational Biology. (Vol. 3, Issue 6) Peer-ReviewedCpG islands were originally identified by epigenetic and functional properties, namely, absence of DNA methylation and frequent promoter association. However, this concept was quickly replaced by simple DNA sequence...
- 20From: PLoS Computational Biology. (Vol. 3, Issue 6) Peer-Revieweddoi:10.1371/journal.pcbi.0030097 In PLoS Computational Biology, volume 3, issue 5, in the Introduction section: The word glucagon was misspelled glucagons. This is the correct sentence: In addition, amylin [181...