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- 1From: PLoS Genetics. (Vol. 3, Issue 2) Peer-ReviewedPhenotypic plasticity is the ability of a genotype to produce contrasting phenotypes in different environments. Although many examples have been described, the responsible mechanisms are poorly understood. In particular,...
- 2From: PLoS Genetics. (Vol. 3, Issue 2) Peer-ReviewedCommon genetic variation could alter the risk for developing bladder cancer. We conducted a large-scale evaluation of single nucleotide polymorphisms (SNPs) in candidate genes for cancer to identify common variants that...
- 3From: PLoS Genetics. (Vol. 3, Issue 2) Peer-ReviewedThe cohesin complexes play a key role in chromosome segregation during both mitosis and meiosis. They establish sister chromatid cohesion between duplicating DNA molecules during S-phase, but they also have an important...
- 4From: PLoS Genetics. (Vol. 3, Issue 2) Peer-ReviewedComparisons of the DNA sequences of metazoa show an excess of transitional over transversional substitutions. Part of this bias is due to the relatively high rate of mutation of methylated cytosines to thymine....
- 5From: PLoS Genetics. (Vol. 3, Issue 2) Peer-ReviewedABSTRACT Mitochondrial DNA (mtDNA) accumulates both base-substitution mutations and deletions with aging in several tissues in mammals. Here, we examine the evidence supporting a causative role for mtDNA mutations in...
- 6From: PLoS Genetics. (Vol. 3, Issue 2) Peer-ReviewedThe genealogical relationship of human, chimpanzee, and gorilla varies along the genome. We develop a hidden Markov model (HMM) that incorporates this variation and relate the model parameters to population genetics...
- 7From: PLoS Genetics. (Vol. 3, Issue 2) Peer-ReviewedChromosome ends are known hotspots of meiotic recombination and double-strand breaks. We monitored mitotic sister chromatid exchange (SCE) in telomeres and subtelomeres and found that 17% of all SCE occurs in the...
- 8From: PLoS Genetics. (Vol. 3, Issue 2) Peer-ReviewedBy means of a computer search for upstream promoter elements (distal sequence element and proximal sequence element) typical of small nuclear RNA genes, we have identified in the human genome a number of previously...
- 9From: PLoS Genetics. (Vol. 3, Issue 2) Peer-ReviewedThe bacterium Neisseria meningitidis is commonly found harmlessly colonising the mucosal surfaces of the human nasopharynx. Occasionally strains can invade host tissues causing septicaemia and meningitis, making the...
- 10From: PLoS Genetics. (Vol. 3, Issue 2) Peer-ReviewedDiploid hybrids of Saccharomyces cerevisiae and its closest relative, Saccharomyces paradoxus, are viable, but the sexual gametes they produce are not. One of several possible causes of this gamete inviability is...
- 11From: PLoS Genetics. (Vol. 3, Issue 2) Peer-ReviewedThe mechanism of circadian oscillations in mammals is cell autonomous and is generated by a set of genes that form a transcriptional autoregulatory feedback loop. While these "clock genes" are well conserved among...
- 12From: PLoS Genetics. (Vol. 3, Issue 2) Peer-ReviewedAge-related degenerative changes in the reproductive system are an important aspect of aging, because reproductive success is the major determinant of evolutionary fitness. Caenorhabditis elegans is a prominent organism...
- 13From: PLoS Genetics. (Vol. 3, Issue 2) Peer-ReviewedFunctional genomics relies on two essential parameters: the sensitivity of phenotypic measures and the power to detect genomic perturbations that cause phenotypic variations. In model organisms, two types of...
- 14From: PLoS Genetics. (Vol. 3, Issue 2) Peer-ReviewedMichel J. Weber doi:10.1371/journal.pgen.0020205 In PLoS Genetics, volume 2, issue 12: In the Materials and Methods, the URL to the Yass online program was incorrectly listed. The correct URL is http://...
- 15From: PLoS Genetics. (Vol. 3, Issue 2) Peer-ReviewedImprinted genes undergo epigenetic modifications during gametogenesis, which lead to transcriptional silencing of either the maternally or the paternally derived allele in the subsequent generation. Previous work has...
- 16From: PLoS Genetics. (Vol. 3, Issue 2) Peer-ReviewedRegulation of gene expression via specific cis-regulatory promoter elements has evolved in cellular organisms as a major adaptive mechanism to respond to environmental change. Assuming a simple model of transcriptional...
- 17From: PLoS Genetics. (Vol. 3, Issue 2) Peer-ReviewedContra vim mortis non crescit herba in hortis. "There is no herb in the gardens against the power of death."--King Sigismund III (1566-1632) on his deathbed Rapid advances in the basic and medical sciences, while...
- 18From: PLoS Genetics. (Vol. 3, Issue 2) Peer-ReviewedThe promoter regions of approximately 40% of genes in the human genome are embedded in CpG islands, CpG-rich regions that frequently extend on the order of one kb 3' of the transcription start site (TSS) region. CpGs 3'...