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- 1From: PLoS Pathogens. (Vol. 3, Issue 2) Peer-ReviewedThere is an urgent need for the development of new antifungal agents. A facile in vivo model that evaluates libraries of chemical compounds could solve some of the main obstacles in current antifungal discovery. We show...
- 2From: PLoS Pathogens. (Vol. 3, Issue 2) Peer-ReviewedA new apoptosis inhibitor is described from vaccinia virus, camelpox virus, and eukaryotic cells. The inhibitor is a hydrophobic, multiple transmembrane protein that is resident in the Golgi and is named GAAP (Golgi...
- 3From: PLoS Pathogens. (Vol. 3, Issue 2) Peer-ReviewedToxoplasma gondii is an obligate intracellular parasite for which the discharge of apical organelles named rhoptries is a key event in host cell invasion. Among rhoptry proteins, ROP2, which is the prototype of a large...
- 4From: PLoS Pathogens. (Vol. 3, Issue 2) Peer-ReviewedThe recent epidemics of bovine spongiform encephalopathy, foot and mouth disease, and avian influenza have focused the attention of the general public and scientific community on veterinary pathogens. Studies on...
- 5From: PLoS Pathogens. (Vol. 3, Issue 2) Peer-ReviewedIntracellular parasitism defines the most intimate of interactions between a pathogen and host. Inherent in this equation are the needs of the pathogen to enter the cell and establish a replication-permissive niche...
- 6From: PLoS Pathogens. (Vol. 3, Issue 2) Peer-ReviewedAPOBEC3G (A3G) is a potent antiretroviral deoxycytidine deaminase that, when incorporated into HIV virions, hypermutates nascent viral DNA formed during reverse transcription. HIV Vif counters the effect of A3G by...
- 7From: PLoS Pathogens. (Vol. 3, Issue 2) Peer-ReviewedViral membrane fusion proceeds through a sequence of steps that are driven by triggered conformational changes of viral envelope glycoproteins, so-called fusion proteins. Although high- resolution structural snapshots...
- 8From: PLoS Pathogens. (Vol. 3, Issue 2) Peer-ReviewedFungal pathogens of humans require molecular oxygen for several essential biochemical reactions, yet virtually nothing is known about how they adapt to the relatively hypoxic environment of infected tissues. We isolated...
- 9From: PLoS Pathogens. (Vol. 3, Issue 2) Peer-ReviewedNumerous bacterial pathogens manipulate host cell processes to promote infection and ultimately cause disease through the action of proteins that they directly inject into host cells. Identification of the targets and...
- 10From: PLoS Pathogens. (Vol. 3, Issue 2) Peer-ReviewedTheiler's virus, a picornavirus, persists for life in the central nervous system of mouse and causes a demyelinating disease that is a model for multiple sclerosis. The virus infects neurons first but persists in white...
- 11From: PLoS Pathogens. (Vol. 3, Issue 2) Peer-ReviewedRecombinant adenoviral (rAd) vectors elicit potent cellular and humoral immune responses and show promise as vaccines for HIV-1, Ebola virus, tuberculosis, malaria, and other infections. These vectors are now widely...
- 12From: PLoS Pathogens. (Vol. 3, Issue 2) Peer-ReviewedThe fungal pathogens Aspergillus fumigatus and Candida albicans are major health threats for immune-compromised patients. Normally, macrophages and neutrophil granulocytes phagocytose inhaled Aspergillus conidia in the...