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- 1From: Nature Methods. (Vol. 3, Issue 2) Peer-ReviewedAuthor(s): Michael Eisenstein Micrometer-sized emulsion droplets form the foundation for an innovative technology that could change how scientists approach high-throughput screening. In every cell, proper function...
- 2From: Nature Methods. (Vol. 3, Issue 2) Peer-ReviewedAuthor(s): Jason N MacLean (corresponding author) [1]; Vivian Fenstermaker [1]; Brendon O Watson [1]; Rafael Yuste [1] The primary visual cortex is the first stage of cortical processing of visual input and is the...
- 3From: Nature Methods. (Vol. 3, Issue 2) Peer-ReviewedAuthor(s): Dario C Ramirez (corresponding author) [1]; Sandra E Gomez Mejiba [1]; Ronald P Mason [1] The Fenton-type system Cu(II)-H2 O2 oxidatively damages DNA and is pathophysiologically important because copper...
- 4From: Nature Methods. (Vol. 3, Issue 2) Peer-ReviewedGenomics A mouse atlas of gene expression: large-scale digital gene-expression profiles from precisely defined developing C57BL/6J mouse tissues and cells Working with tags from 72 different LongSAGE libraries,...
- 5From: Nature Methods. (Vol. 3, Issue 2) Peer-ReviewedAuthor(s): Meng Li [1]; Frank Diehl [1]; Devin Dressman [1]; Bert Vogelstein (corresponding author) [1]; Kenneth W Kinzler (corresponding author) [1] BEAMing allows the one-to-one conversion of a population of DNA...
- 6From: Nature Methods. (Vol. 3, Issue 2) Peer-ReviewedAuthor(s): Nicole Rusk By allowing a differentiated somatic nucleus to form metaphase chromosomes its chromatin is remodeled in a way that adapts its replication properties to the early embryonic context. The recent...
- 7From: Nature Methods. (Vol. 3, Issue 2) Peer-ReviewedThis protocol describes a single-step technique for the purification of RNA. Cells are homogenized in guanidinium thiocyanate and the RNA is purified from the lysate by extraction with phenol-chloroform at reduced pH...
- 8From: Nature Methods. (Vol. 3, Issue 2) Peer-ReviewedAuthor(s): Jolanta Szulc [1, 3]; Maciej Wiznerowicz [1, 2, 3]; Marc-Olivier Sauvain [1, 2]; Didier Trono (corresponding author) [1, 2, 4]; Patrick Aebischer (corresponding author) [1, 4] As the genome sequence of a...
- 9From: Nature Methods. (Vol. 3, Issue 2) Peer-ReviewedAuthor(s): Philipp Selenko [1]; Gerhard Wagner [1] Almost all biology has evolved within the boundaries of cellular structures, and every intracellular space represents a highly crowded, viscous solute that harbors an...
- 10From: Nature Methods. (Vol. 3, Issue 2) Peer-ReviewedAuthor(s): Michael Eisenstein Two high-throughput 'kinomic' analysis strategies could provide kinase researchers with a bounty of information about the targets and the regulation of their favorite enzymes. It's...
- 11From: Nature Methods. (Vol. 3, Issue 2) Peer-ReviewedAuthor(s): Allison Doerr The Diels-Alder cycloaddition, a classic synthetic organic reaction, is now being harnessed to label proteins. Biologists never seem to lose their hunger for new chemical labeling strategies....
- 12From: Nature Methods. (Vol. 3, Issue 2) Peer-ReviewedAuthor(s): Michael Eisenstein People have been working with RNA for the better part of a century now. However, the earliest RNA preparation techniques were often inefficient and unreliable--involving boiling, extreme...
- 13From: Nature Methods. (Vol. 3, Issue 2) Peer-ReviewedAuthor(s): Nozomi Nishimura [1, 2]; Chris B Schaffer [1, 2]; Beth Friedman [3]; Philbert S Tsai [1, 2]; Patrick D Lyden [3, 4]; David Kleinfeld (corresponding author) [1, 2, 4] Brain homeostasis depends on adequate...
- 14From: Nature Methods. (Vol. 3, Issue 2) Peer-ReviewedAuthor(s): Daniel Evanko A method to select for proteins that are highly efficient at folding yields 'superfolder' GFP, an optimized GFP for use in protein fusions. Fusion proteins are powerful tools for the...
- 15From: Nature Methods. (Vol. 3, Issue 2) Peer-ReviewedAuthor(s): Karl-Heinz Esser [1]; Wolfram H Marx (corresponding author) [2]; Thomas Lisowsky (corresponding author) [1] The polymerase chain reaction (PCR) has set the standard for DNA amplification technology [1], and...
- 16From: Nature Methods. (Vol. 3, Issue 2) Peer-ReviewedAuthor(s): Tuan N Nguyen [1]; James A Goodrich (corresponding author) [1] Many methods commonly used to identify and characterize interactions between two or more proteins are variations of the immobilized...
- 17From: Nature Methods. (Vol. 3, Issue 2) Peer-ReviewedAuthor(s): Steve N Bailey [1]; Siraj M Ali [1]; Anne E Carpenter [1]; Caitlin O Higgins [1]; David M Sabatini (corresponding author) [1] RNA interference (RNAi) technology allows for loss-of-function studies in...
- 18From: Nature Methods. (Vol. 3, Issue 2) Peer-ReviewedThe first lentiviral gene transfer vector, derived from HIV, was described in 1996 in a seminal article alluding to great promises for gene therapy (Science 272, 263; 1996). With time and design modifications, this...
- 19From: Nature Methods. (Vol. 3, Issue 2) Peer-ReviewedAuthor(s): Robert Flaumenhaft [1]; Eng H Lo [2] The decade of the 1990s produced considerable advances in the molecular understanding of neuronal cell death after stroke [1]. Intricate intracellular pathways were...
- 20From: Nature Methods. (Vol. 3, Issue 2) Peer-ReviewedAuthor(s): Laura Bonetta [1] The sequencing of genomes has become a mainstay of biological research. According to the genome project database of the National Institutes of Health (NIH) National Center for Biotechnology...