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- 1From: PLoS Genetics. (Vol. 3, Issue 12) Peer-ReviewedInstitute for Molecular Biosciences, Goethe-University, Frankfurt, Germany The basal transcription apparatus of archaea is well characterized. However, much less is known about the mechanisms of transcription...
- 2From: PLoS Genetics. (Vol. 3, Issue 12) Peer-ReviewedShp2 is a cytoplasmic protein-tyrosine phosphatase that is essential for normal development. Activating and inactivating mutations have been identified in humans to cause the related Noonan and LEOPARD syndromes,...
- 3From: PLoS Genetics. (Vol. 3, Issue 12) Peer-ReviewedBacteria are sometimes honored with a few lines in books and reviews on aging as an example of organisms that do not age. This is because binary fission of bacteria has been assumed to proceed with a nonconservative...
- 4From: PLoS Genetics. (Vol. 3, Issue 12) Peer-ReviewedPrader-Willi syndrome (PWS [MIM 176270]) is a neurogenetic disorder characterized by decreased fetal activity, muscular hypotonia, failure to thrive, short stature, obesity, mental retardation, and hypogonadotropic...
- 5From: PLoS Genetics. (Vol. 3, Issue 12) Peer-ReviewedThe cyclin-dependent kinase inhibitor [p27.sup.KIP1] is a tumor suppressor gene in mice, and loss of p27 protein is a negative prognostic indicator in human cancers. Unlike other tumor suppressors, the p27 gene is...
- 6From: PLoS Genetics. (Vol. 3, Issue 12) Peer-ReviewedTo investigate the DNA damage response, we undertook a genome-wide study in Saccharomyces cerevisiae and identified 86 gene deletions that lead to increased levels of spontaneous Rad52 foci in proliferating diploid...
- 7From: PLoS Genetics. (Vol. 3, Issue 12) Peer-ReviewedSuccessful reproduction is critical to pass genes to the next generation. Seminal proteins contribute to important reproductive processes that lead to fertilization in species ranging from insects to mammals. In...
- 8From: PLoS Genetics. (Vol. 3, Issue 12) Peer-ReviewedChromosome organizations of related bacterial genera are well conserved despite a very long divergence period. We have assessed the forces limiting bacterial genome plasticity in Escherichia coli by measuring the...
- 9From: PLoS Genetics. (Vol. 3, Issue 12) Peer-ReviewedMitogen-activated protein kinase (MAPK) and PUF (for Pumilio and FBF [fem-3 binding factor]) RNA-binding proteins control many cellular processes critical for animal development and tissue homeostasis. In the present...
- 10From: PLoS Genetics. (Vol. 3, Issue 12) Peer-ReviewedChromosomal inversion polymorphisms are thought to play a role in adaptive divergence, but the genes conferring adaptive benefits remain elusive. Here we study 2La, a common polymorphic inversion in the African malaria...
- 11From: PLoS Genetics. (Vol. 3, Issue 12) Peer-ReviewedHigh-throughput studies of the 6,200 genes of Saccharomyces cerevisiae have provided valuable data resources. However, these resources require a return to experimental analysis to test predictions. An in-silico screen,...
- 12From: PLoS Genetics. (Vol. 3, Issue 12) Peer-ReviewedResearch Center, Seattle, Washington, United States of America Subtelomeres are duplication-rich, structurally variable regions of the human genome situated just proximal of telomeres. We report here that the most...
- 13From: PLoS Genetics. (Vol. 3, Issue 12) Peer-ReviewedMammalian Argonaute proteins (EIF2C1-4) play an essential role in RNA-induced silencing. Here, we show that the loss of eIF2C2 (Argonaute2 or Agog) results in gastrulation arrest, ectopic expression of Brachyury (T),...
- 14From: PLoS Genetics. (Vol. 3, Issue 12) Peer-ReviewedProchlorococcus is a marine cyanobacterium that numerically dominates the mid-latitude oceans and is the smallest known oxygenic phototroph. Numerous isolates from diverse areas of the world's oceans have been studied...
- 15From: PLoS Genetics. (Vol. 3, Issue 12) Peer-ReviewedProtein Phosphatase type 2A (PP2A) represents a family of holoenzyme complexes with diverse biological activities. Specific holoenzyme complexes are thought to be deregulated during oncogenic transformation and...
- 16From: PLoS Genetics. (Vol. 3, Issue 12) Peer-ReviewedSpinocerebellar ataxias (SCAB) are a genetically heterogeneous group of neurodegenerative disorders sharing atrophy of the cerebellum as a common feature. SCA1 and SCA2 are two ataxias caused by expansion of...
- 17From: PLoS Genetics. (Vol. 3, Issue 12) Peer-ReviewedCommunication in the field of biogerontology is a minefield because all of the commonly used terms have no universally accepted definitions. In a series of five annual meetings that I chaired recently in an attempt to...
- 18From: PLoS Genetics. (Vol. 3, Issue 12) Peer-ReviewedThe Drosophila melanogaster photoreceptor cell has long served as a model system for researchers focusing on how animal sensory neurons receive information from their surroundings and translate this information into...
- 19From: PLoS Genetics. (Vol. 3, Issue 12) Peer-ReviewedHox genes encode homeodomain-containing proteins that control embryonic development in multiple contexts. Up to 30 Hox genes, distributed among all four clusters, are expressed during mammalian kidney morphogenesis, but...